Chemotherapy-Induced Apoptosis

Free radicals in biology and medicine

1991 • 17,840 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

The Fas Death Factor

1995 • 4,070 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Apoptosis. Its significance in cancer and cancer Therapy

1994 • 2,148 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Cancer: Principles and Practice of Oncology

1994 • 1,825 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

1994 • 1,431 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note

1995 • 1,171 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

1992 • 1,063 citations

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

1996 • 1,001 citations

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

1993 • 997 citations

RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1995 • 964 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia

1990 • 887 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli

1991 • 816 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

Continuous c-fos expression precedes programmed cell death in vivo

1993 • 784 citations

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

1996 • 746 citations

Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death

1995 • 744 citations

High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy

1993 • 738 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

DNA Topoisomerases: Essential Enzymes and Lethal Targets

1994 • 722 citations

Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques.

1994 • 697 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

The head involution defective gene of Drosophila melanogaster functions in programmed cell death.

1995 • 685 citations

bcl-2 Protein in Non-Small-Cell Lung Carcinoma

1993 • 684 citations

Ceramide activates heterotrimeric protein phosphatase 2A

1993 • 657 citations

A License to Kill

1996 • 649 citations

Regulators of cell death

1995 • 647 citations

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1992 • 647 citations

Death and the cell

1986 • 616 citations

Functional Organization Of The Nuclear Envelope

1988 • 593 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications

1983 • 585 citations

In situ end‐labelling detects DNA strand breaks in apoptosis and other physiological and pathological states

1993 • 584 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

The role of proteases during apoptosis

1996 • 558 citations

Do all programmed cell deaths occur via apoptosis?

1993 • 545 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

Nuclear changes in apoptosis

1995 • 538 citations

Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.

1996 • 535 citations

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

1996 • 529 citations

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

1995 • 524 citations

Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia

1994 • 514 citations

Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

1995 • 501 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 495 citations

Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis.

1990 • 489 citations

Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification.

1996 • 488 citations

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.

1992 • 487 citations

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

1995 • 486 citations

Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.

1995 • 477 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

Cell Death Mechanisms and the Immune System

1991 • 459 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

Programmed cell death—I. Cytology of degeneration in the intersegmental muscles of the Pernyi silkmoth

1965 • 449 citations

Identification of Deoxyribonuclease II as an Endonuclease Involved in Apoptosis

1993 • 428 citations

Expression of bcl-xL can confer a multidrug resistance phenotype

1995 • 421 citations

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

1994 • 410 citations

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.

1995 • 407 citations

Cell cycle and apoptosis: Common pathways to life and death

1995 • 404 citations

Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines.

1992 • 401 citations

Programmed cell death, apoptosis and killer genes

1993 • 396 citations

Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes.

1991 • 392 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 378 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.

1996 • 371 citations

Requirement for RNA and protein synthesis for induced regression of the tadpole tail in organ culture

1966 • 364 citations

Cascade Induction of c-fos, c-myc, and Heat Shock 70K Transcripts during Regression of the Rat Ventral Prostate Gland

1988 • 355 citations

Activation of cyclin A-dependent protein kinases during apoptosis.

1994 • 352 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

bcl-2and Other Genomic Alterations in the Prognosis of Large-Cell Lymphoma

1989 • 309 citations

ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

1996 • 304 citations

An electron‐microscope study of the mode of cell death induced by cancer‐chemotherapeutic agents in populations of proliferating normal and neoplastic cells

1975 • 300 citations

Shared Actions of Endotoxin and Taxol on TNF Receptors and TNF release

1990 • 288 citations

Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification.

1993 • 286 citations

Bleomycin, an apoptosis-mimetic drug that induces two types of cell death depending on the number of molecules internalized.

1993 • 277 citations

Detection of DNA fragmentation in apoptosis: application of in situ nick translation to cell culture systems and tissue sections.

1993 • 276 citations

Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis.

1993 • 275 citations

Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells.

1993 • 273 citations

Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide.

1992 • 272 citations

ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis

1996 • 267 citations

Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells

1993 • 262 citations

Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification.

1993 • 262 citations

Apoptosis in an Interleukin-2-dependent Cytotoxic T Lymphocyte Cell Line Is Associated with Intracellular Acidification

1995 • 243 citations

Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei.

1995 • 242 citations

Suppression of Apoptosis by Dominant Negative Mutants of Cyclin-dependent Protein Kinases

1996 • 239 citations

bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways.

1993 • 238 citations

Apoptosis Biochemical events and relevance to cancer chemotherapy

1992 • 238 citations

Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis.

1996 • 232 citations

Identification and Characterization of Ich-3, a Member of the Interleukin-1β Converting Enzyme (ICE)/Ced-3 Family and an Upstream Regulator of ICE

1996 • 231 citations

Effects of recombinant human GM-CSF on proliferation of clonogenic cells in acute myeloblastic leukemia

1986 • 223 citations

THE BIOLOGY OF CELL DEATH IN TUMOURS

1973 • 222 citations

Bcl-xL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis.

1995 • 220 citations

bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair.

1993 • 218 citations

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

1997 • 211 citations

Turning on the respiratory burst

1990 • 211 citations

Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival.

1996 • 206 citations

Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node-positive breast cancer.

1995 • 203 citations

Ionizing radiation activates transcription of the EGR1 gene via CArG elements.

1992 • 200 citations

Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by 1-beta-D-arabinofuranosylcytosine.

1991 • 198 citations

Apoptosis or necrosis: Intracellular levels of glutathione influence mode of cell death

1994 • 197 citations

Synaptic Vesicle Ceramide Kinase

1989 • 195 citations

Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells

1993 • 194 citations

Cancer therapy and p53

1995 • 194 citations

Prognostic value of bcl-2 expression in invasive breast cancer

1995 • 192 citations

Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells.

1996 • 190 citations

The S-phase cytotoxicity of camptothecin

1991 • 190 citations

Requirement of AP-1 for Ceramide-induced Apoptosis in Human Leukemia HL-60 Cells

1995 • 186 citations

Fludarabine- and gemcitabine-induced apoptosis: incorporation of analogs into DNA is a critical event

1995 • 181 citations

Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells.

1993 • 177 citations

Activation of a Ca²⁺−Mg²⁺‐dependent endonuclease as an early event in castration‐induced prostatic cell death

1988 • 176 citations

Reactive oxygen intermediates target CC(A/T)6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation.

1993 • 172 citations

Death by suicide: one way to go in mammalian cellular development?

1991 • 167 citations

Free radicals and anticancer drug resistance: Oxygen free radicals in the mechanisms of drug cytotoxicity and resistance by certain tumors

1990 • 166 citations

1-beta-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells.

1994 • 166 citations

Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line.

1991 • 165 citations

Aphidicolin: a specific inhibitor of nuclear DNA replication in eukaryotes

1982 • 159 citations

Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells.

1993 • 157 citations

Taxol, a microtubule-stabilizing antineoplastic agent, induces expression of tumor necrosis factor α and interleukin-1 in macrophages

1992 • 153 citations

Effects of cisplatin on the induction of apoptosis in proliferating hepatoma cells and nonproliferating immature thymocytes.

1993 • 149 citations

BCL-2 expression delays drug-induced apoptosis but does not increase clonogenic survival after drug treatment in HeLa cells.

1995 • 144 citations

Colchicine Induces Apoptosis in Cerebellar Granule Cells

1995 • 143 citations

Increased Expression of the Insulin-like Growth Factor-II Gene in Wilms' Tumor Is Not Dependent on Loss of Genomic Imprinting or Loss of Heterozygosity

1996 • 140 citations

How loops, β sheets, and α helices help us to understand p53

1994 • 140 citations

Effects of recombinant GM-CSF on the blast cells of acute myeloblastic leukemia

1986 • 139 citations

Clonal expansion and attenuated apoptosis in Wilms' tumors are associated with p53 gene mutations.

1995 • 138 citations

A timetable of events during programmed cell death induced by trophic factor withdrawal from neuronal PC12 cells

1995 • 138 citations

Differential induction of secondary DNA fragmentation by topoisomerase II inhibitors in human tumor cell lines with amplified c-myc expression.

1991 • 137 citations

Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2.

1995 • 137 citations

Studies of cellular proliferation in human leukemia.III. Behavior of leukemic cells in three adults with acute leukemia given continuous infusions of3H-thymidine for 8 or 10 days

1970 • 132 citations

Immunohistochemically detectable bcl-2 expression in colorectal carcinoma: correlation with tumour stage and patient survival

1995 • 131 citations

The gene family

1995 • 130 citations

Ceramide and the induction of apoptosis.

1996 • 128 citations

The helix-loop-helix/leucine repeat transcription factor USF can be functionally regulated in a redox-dependent manner.

1992 • 127 citations

c-Abl Activation Regulates Induction of the SEK1/Stress-activated Protein Kinase Pathway in the Cellular Response to 1-β-D-Arabinofuranosylcytosine

1995 • 125 citations

Calcium/magnesium-dependent endonuclease from human spleen: Purification, properties, and role in apoptosis

1993 • 123 citations

Cisplatin Induces Apoptosis in a Human Ovarian Carcinoma Cell Line without Concomitant Internucleosomal Degradation of DNA

1994 • 123 citations

Glucocorticoid-induced Apoptosis of Lymphoid Cells

1994 • 122 citations

Antibody against single-stranded DNA detects both programmed cell death and drug-induced apoptosis

1994 • 122 citations

Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3.

1995 • 115 citations

Apoptosis in murine tumors treated with chemotherapy agents

1995 • 115 citations

The fates of chicken nuclear lamin proteins during mitosis: evidence for a reversible redistribution of lamin B2 between inner nuclear membrane and elements of the endoplasmic reticulum.

1988 • 110 citations

L-asparaginase kills lymphoma cells by apoptosis

1993 • 110 citations

Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes

1993 • 109 citations

Camptothecin, teniposide, or 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells.

1991 • 109 citations

“Thymineless” death in androgen-independent prostatic cancer cells

1989 • 101 citations

Time Course of Early Events in the Action of Glucocorticoids on Rat Thymus Cells in Vitro

1973 • 100 citations

Drug-induced DNA damage and tumor chemosensitivity.

1990 • 96 citations

Apoptotic Cell Death During Treatment of Leukemias

1994 • 96 citations

The topoisomerase II inhibitor teniposide (VM-26) induces apoptosis in unstimulated mature murine lymphocytes

1992 • 95 citations

Disruption of microtubules induces an endogenous suicide pathway in human leukaemia HL‐60 cells

1990 • 89 citations

Bcl-xL overexpression inhibits taxol-induced Yama protease activity and apoptosis.

1996 • 88 citations

Inhibitors of proteases prevent endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes.

1992 • 86 citations

Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard.

1991 • 85 citations

High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells

1993 • 85 citations

Reevaluation of the Role of de Novo Protein Synthesis in Rat Thymocyte Apoptosis

1995 • 82 citations

Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: implications for mechanisms of resistance and cytotoxicity.

1992 • 82 citations

Detection and characterization of ceramide-1-phosphate phosphatase activity in rat liver plasma membrane.

1993 • 78 citations

An Adherent Cell Model to Study Different Stages of Apoptosis

1995 • 78 citations

Distribution of deoxyribonuclease I in rat tissues and its correlation to cellular turnover and apoptosis (programmed cell death).

1994 • 77 citations

Characterization of Apoptotic Phenomena Induced by Treatment with L-Asparaginase in NIH3T3 Cells

1995 • 77 citations

Coinduction of c-jun gene expression and internucleosomal DNA fragmentation by ionizing radiation

1993 • 77 citations

Activation of the c-jun protooncogene in human myeloid leukemia cells treated with etoposide.

1991 • 74 citations

Selective induction of apoptosis in Hep 3B cells by topoisomerase I inhibitors: evidence for a protease-dependent pathway that does not activate cysteine protease P32.

1996 • 73 citations

Differential sensitivity to the induction of apoptosis by cisplatin in proliferating and quiescent immature rat thymocytes is independent of the levels of drug accumulation and DNA adduct formation.

1994 • 72 citations

cis-Diamminedichloroplatinum(II) induces c-jun expression in human myeloid leukemia cells: potential involvement of a protein kinase C-dependent signaling pathway.

1992 • 72 citations

Taxol cytotoxicity on human leukemia cell lines is a function of their susceptibility to programmed cell death

1995 • 69 citations

Proliferative Potential of Out-of-cycle Leukaemic Cells

1969 • 68 citations

CDC2 Activation Is Not Required for Thymocyte Apoptosis

1994 • 67 citations

The digestion of cellular fragments within phagolysosomes in carcinoma cells

1972 • 67 citations

Camptothecin and its derivatives induce expression of the c-jun protooncogene in human myeloid leukemia cells.

1991 • 66 citations

Programmed cell death and adenine deoxynucleotide metabolism in human lymphocytes

1988 • 61 citations

Programmed cell death (apoptosis) of mouse fibroblasts is induced by the topoisomerase II inhibitor etoposide.

1994 • 58 citations

Pretreatment cytokinetic studies in 94 children with acute leukemia. Relationship to other variables at diagnosis and to outcome of standard treatment

1977 • 58 citations

Relationship between the pretreatment proliferative activity of marrow blast cells and prognosis of acute lymphoblastic leukaemia of childhood

1980 • 57 citations

Apoptosis: A sticky business

1995 • 57 citations

Monocyte Colony-stimulating Factor Stimulates Binding of Phosphatidylinositol 3-Kinase to Grb2·Sos Complexes in Human Monocytes

1995 • 56 citations

Paclitaxel (taxol) inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells.

1995 • 56 citations

Paclitaxel induces programmed cell death in MDA-MB-468 human breast cancer cells.

1996 • 56 citations

Mechanism of tissue-specific induction of internucleosomal deoxyribonucleic acid cleavage activity and apoptosis by glucocorticoids.

1993 • 54 citations

The acid deoxyribonuclease of neutrophils: a possible participant in apoptosis-associated genome destruction

1995 • 53 citations

Programmed cell death in response to chemotherapeutic agents in human germ cell tumour lines

1995 • 52 citations

Topoisomerase inhibitors induce irreversible fragmentation of replicated DNA in concanavalin A stimulated splenocytes

1988 • 50 citations

Doxorubicin-induced DNA degradation in murine thymocytes.

1994 • 48 citations

p53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs

1995 • 48 citations

Role of the BCR-ABL oncogene in human leukemia: fifteenth Richard and Hinda Rosenthal Foundation Award Lecture.

1993 • 46 citations

The suppression of drug-induced apoptosis by activation of v-ABL protein tyrosine kinase.

1994 • 45 citations

Expression of bcl‐2 gene product in neuroblastoma

1994 • 44 citations

Differences between drug-sensitive and -resistant human leukemic CEM cells in c-jun expression, AP-1 DNA-binding activity, and formation of Jun/Fos family dimers, and their association with internucleosomal DNA ladders after treatment with VM-26.

1994 • 44 citations

Apoptosis induction with three nucleoside analogs on freshly isolated B‐chronic lymphocytic leukemia cells

1994 • 43 citations

Determination of intracellular calcium in vivo via fluorine-19 nuclear magnetic resonance spectroscopy

1995 • 42 citations

Apoptosis and the Prognostic Significance of p53 Mutation

1994 • 42 citations

Relationship of pretreatment lymphoblast proliferative activity and prognosis in 97 children with acute lymphoblastic leukemia

1982 • 40 citations

Oxidative damage and repair in the developing nervous system.

1994 • 40 citations

Assessment of apoptosis in oesophageal carcinoma preoperatively treated by chemotherapy and radiotherapy.

1995 • 38 citations

Cell death induced by vincristine in the intestinal crypts of mice and in a human Burkitt's lymphoma cell line

1992 • 37 citations

Metabolic effects and kill of human T-cell leukemia by 5-deazaacyclotetrahydrofolate, a specific inhibitor of glycineamide ribonucleotide transformylase.

1992 • 37 citations

Etoposide induces programmed death in neurons cultured from the fetal rat central nervous system

1994 • 37 citations

Expression of c-fos in human and murine multidrug-resistant cells.

1992 • 36 citations

Proteolytic cleavage during chemotherapy-induced apoptosis

1996 • 35 citations

Induction of apoptosis in childhood acute leukemia by chemotherapeutic agents: Failure to detect evidence of apoptosis in vivo

1994 • 33 citations

Production of interleukin-1 and tumor necrosis factor by bone marrow-derived macrophages: effect of cisplatin and lipopolysaccharide

1991 • 31 citations

Transfection with a bcl-2 expression vector protects transplanted bone marrow from chemotherapy-induced myelosuppression.

1994 • 30 citations

Actinomycin D: effects on Ridgway osteogenic sarcoma in mice.

1966 • 28 citations

Effects of granulocyte-macrophage colony-stimulating factor and erythropoietin on leukemic erythroid colony formation in human early erythroblastic leukemias

1987 • 28 citations

Biochemical Modulation of Tumor Cell Energy in Vivo: II. A Lower Dose of Adriamycin is Required and a Greater Antitumor Activity is Induced when Cellular Energy is Depressed

1994 • 28 citations

Mechanism of tissue-specific induction of internucleosomal deoxyribonucleic acid cleavage activity and apoptosis by glucocorticoids

1993 • 27 citations

Physiology and Protein Synthesis in Programmed Cell Death

1992 • 27 citations

Inhibition of etoposide (VP-16)-induced DNA recombination and mutant frequency by Bcl-2 protein overexpression.

1995 • 27 citations

Hemopoietins in oncology: factoring out myelosuppression.

1989 • 25 citations

Cisplatin induces apoptosis in SH-SY5Y human neuroblastoma cell line.

1995 • 25 citations

Hydroxyurea induces apoptosis and regular DNA fragmentation in a Burkitt's lymphoma cell line

1992 • 25 citations

Induction of “In Vitro” Apoptosis by Fludarabine in Freshly Isolated B-Chronic Lymphocytic Leukemia Cells

1994 • 23 citations

Low-dose-melphalan-induced up-regulation of type-1 cytokine expression in the s.c. tumor nodule of MOPC-315 tumor bearers and the role of interferon γ in the therapeutic outcome

1995 • 22 citations

Changes in c-myc and c-fos expression in a human tumor cell line following exposure to bifunctional alkylating agents.

1990 • 22 citations

Apoptosis induced by etoposide in small-cell lung cancer cell lines

1994 • 21 citations

Increased production of interleukin-1 and tumor necrosis factor by human monocytes treated in vitro with cisplatin or other biological response modifiers

1992 • 20 citations

Effects of granulocyte-macrophage colony-stimulating factor and erythropoietin on leukemic erythroid colony formation in human early erythroblastic leukemias

1987 • 19 citations

Impact of in vivo administration of interleukin 3 on proliferation, differentiation, and chemosensitivity of acute myeloid leukemia.

1995 • 19 citations

1-ß-d-arabinosylcytosine and 5-azacytidine induce internucleosomal DNA fragmentation and cell death in thymocytes

1992 • 17 citations

Evidence against a direct role for the induction of c-jun expression in the mediation of drug-induced apoptosis in human acute leukemia cells.

1995 • 14 citations

Effects of chemotherapy on ultrastructure of oesophageal squamous cell carcinoma

1994 • 7 citations

Induction of c-fos Gene Expression by Arabinofuranosylcytosine in Human KG-1 Leukemia Cells

1990 • 6 citations

TNF receptor fusion protein in rheumatoid arthritis

1996 • 5 citations

Modulation of Cytotoxicity and Differentiation-Inducing Potential of Arabinofuranosylcytosine in Myeloid Leukemia Cells by Hematopoietic Cytokines

1993 • 5 citations