p53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

A Detergent‐trypsin method for the preparation of nuclei for flow cytometric DNA analysis

1983 • 1,681 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae

1988 • 1,174 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Apoptosis induced by anticancer drugs

1992 • 861 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1994 • 538 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.

1992 • 487 citations

Growth factor modulation of p53-mediated growth arrest versus apoptosis.

1995 • 377 citations

p53-mediated cell death: relationship to cell cycle control.

1993 • 339 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity.

1994 • 333 citations

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

1993 • 305 citations

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

1994 • 276 citations

Cell death in health and disease: the biology and regulation of apoptosis

1995 • 245 citations

p53 Functions as a Cell Cycle Control Protein in Osteosarcomas

1990 • 224 citations

Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2.

1993 • 214 citations

Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells.

1993 • 196 citations

Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro.

1988 • 168 citations

Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.

1994 • 168 citations

p53-Mediated Cell Death: Relationship to Cell Cycle Control

1993 • 98 citations

The topoisomerase II inhibitor teniposide (VM-26) induces apoptosis in unstimulated mature murine lymphocytes

1992 • 95 citations

Complementation by Wild-Type p53 of Interleukin-6 Effects on M1 Cells: Induction of Cell Cycle Exit and Cooperativity with c-myc Suppression

1993 • 91 citations

Preferential damage of active chromatin by bleomycin.

1981 • 85 citations

Mutant p53 increases radioresistance in rat embryo fibroblasts simultaneously transfected with HPV16-E7 and/or activated H-ras.

1994 • 83 citations

Molecular mechanisms of drug resistance in tumours

1995 • 81 citations

Differential sensitivity to the induction of apoptosis by cisplatin in proliferating and quiescent immature rat thymocytes is independent of the levels of drug accumulation and DNA adduct formation.

1994 • 72 citations

Myc-Mediated Apoptosis Is Blocked by Ectopic Expression of Bcl-2

1993 • 57 citations

Cell Cycle Analysis of p53-Induced Cell Death in Murine Erythroleukemia Cells

1993 • 54 citations

Lymphocyte Apoptosis ‐ Mechanisms and Implications in Disease

1994 • 38 citations

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

1993 • 24 citations

Apoptosis: molecular aspects and pathological perspective

1994 • 12 citations