Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

DNA TOPOISOMERASES

1985 • 1,524 citations

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

1989 • 1,030 citations

Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli

1991 • 784 citations

DNA Topoisomerases: Essential Enzymes and Lethal Targets

1994 • 722 citations

DNA Gyrase: Structure and Function

1991 • 679 citations

The Current Status of Camptothecin Analogues as Antitumor Agents

1993 • 614 citations

DNA topology and its biological effects

1991 • 612 citations

Fluoroquinolone Antimicrobial Agents

1991 • 562 citations

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

1984 • 559 citations

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

1989 • 533 citations

DNA topoisomerase-targeting antitumor drugs can be studied in yeast.

1988 • 490 citations

Topoisomerase II: A specific marker for cell proliferation.

1986 • 434 citations

Quinolone antimicrobial agents

1989 • 421 citations

Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II

1989 • 409 citations

Structure and function of type II DNA topoisomerases

1994 • 400 citations

Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones

1994 • 376 citations

Antitumor bisdioxopiperazines inhibit yeast DNAtopoisomerase II by trapping the enzyme in the form of a closed proteinclamp.

1994 • 339 citations

The role of topoisomerase IV in partitioning bacterial replicons and the structure of catenated intermediates in DNA replication

1992 • 337 citations

Escherichia coli Mutants Thermosensitive for Deoxyribonucleic Acid Gyrase Subunit A: Effects on Deoxyribonucleic Acid Replication, Transcription, and Bacteriophage Growth

1979 • 337 citations

The structural basis of camptothecin interactions with human serum albumin: impact on drug stability

1994 • 316 citations

Eukaryotic DNA topoisomerases I

1995 • 307 citations

Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin.

1989 • 260 citations

Biochemical basis for the interactions of type I and type II topoisomerases with DNA

1989 • 251 citations

A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex

1993 • 250 citations

Catalytic function of DNA topoisomerase II

1991 • 246 citations

Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide

1989 • 228 citations

Cellular Determinants of Sensitivity and Resistance to DNA Topoisomerase Inhibitors

1994 • 208 citations

When good enzymes go bad: Conversion of topoisomerase II to a cellular toxin by antineoplastic drugs

1993 • 203 citations

Yeast DNA topoisomerase II is encoded by a single-copy, essential gene

1984 • 175 citations

DNA topoisomerase I and II in cancer chemotherapy: update and perspectives

1993 • 174 citations

Topoisomerase Inhibitors

1995 • 173 citations

The molecular basis of quinolone action

1992 • 169 citations

Structure of the Drosophila DNA topoisomerase II gene

1989 • 153 citations

Mutagenicity and carcinogenicity of topoisomerase-interactive agents

1994 • 152 citations

The Strange Case of Dr. Jekyll and Mr. Hyde and Other Stories

1886 • 151 citations

The Strange Case of Dr. Jekyll and Mr. Hyde

2001 • 148 citations

Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells.

1987 • 147 citations

Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage

1991 • 147 citations

Topoisomerase II Binds to Ellipticine in the Absence or Presence of DNA.

1995 • 136 citations

The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I

1989 • 126 citations

Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus

1991 • 122 citations

Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II.

1992 • 122 citations

Mode of action of topoisomerase II-targeting agents at a specific DNA sequence

1992 • 121 citations

Differential Stabilization of Eukaryotic DNA Topoisomerase I Cleavable Complexes by Camptothecin Derivatives

1995 • 121 citations

Overexpression of human topoisomerase I in baby hamster kidney cells: hypersensitivity of clonal isolates to camptothecin.

1992 • 114 citations

Effects of topoisomerase II-targeted drugs on enzyme-mediated DNA cleavage and ATP hydrolysis: Evidence for distinct drug interaction domains on topoisomerase II

1993 • 93 citations

Topoisomerase II enzymes and mutagenicity

1994 • 88 citations

A Yeast Type II Topoisomerase Selected for Resistance to Quinolones

1995 • 86 citations

Characterization of a camptothecin-resistant human DNA topoisomerase I.

1988 • 82 citations

A temperature sensitive topoisomerase II allele confers temperature dependent drug resistance on amsacrine and etoposide: a genetic system for determining the targets of topoisomerase II inhibitors.

1993 • 82 citations

The twisted ‘life’ of DNA in the cell: bacterial topoisomerases

1995 • 78 citations

Role of nonhistone proteins in the chromosomal events of mitosis

1994 • 77 citations

Drug resistance associated with altered DNA topoisomerase II

1993 • 76 citations

Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase.

1994 • 73 citations

DNA topoisomerase II is the molecular target of bisdioxopiperazine derivatives ICRF-159 and ICRF-193 in Saccharomyces cerevisiae.

1995 • 72 citations

DNA topoisomerase-trapping antitumour drugs

1992 • 69 citations

Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.

1994 • 65 citations

Molecular Interactions of DNA-Topoisomerase I and II Inhibitor with DNA and Topoisomerases and in Ternary Complexes: Binding Modes and Biological Effects for Intoplicine Derivatives

1994 • 64 citations

Saintopin, a dual inhibitor of DNA topoisomerases I and II, as a probe for drug-enzyme interactions.

1994 • 61 citations

The performance of short-term tests in identifying potential germ cell mutagens: a qualitative and quantitative analysis

1994 • 61 citations

A Mutation in Yeast TOP2 Homologous to a Quinolone-resistant Mutation in Bacteria

1995 • 56 citations

Relationship of DNA topoisomerase II alpha and beta expression to cytotoxicity of antineoplastic agents in human acute lymphoblastic leukemia cell lines.

1995 • 55 citations

A Camptothecin-resistant DNA Topoisomerase I Mutant Exhibits Altered Sensitivities to Other DNA Topoisomerase Poisons

1995 • 52 citations

Exploiting mechanistic differences between drug classes to define functional drug interaction domains on topoisomerase II. Evidence that several diverse DNA cleavage-enhancing agents share a common site of action on the enzyme

1993 • 52 citations

Roles of DNA Topoisomerases in Chromosomal Replication and Segregation

1994 • 44 citations

Using yeast to study resistance to topoisomerase II-targeting drugs

1994 • 44 citations

Resistance of Mammalian Tumor Cells to Inhibitors of DNA Topoisomerase II

1994 • 40 citations

Cross-resistance of an amsacrine-resistant human leukemia line to topoisomerase II reactive DNA intercalating agents. Evidence for two topoisomerase II directed drug actions

1991 • 38 citations

DNA topoisomerases

1995 • 32 citations

Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes

1994 • 31 citations

YeastSaccharomyces cerevisiae as a model system to study the cytotoxic activity of the antitumor drug camptothecin

1994 • 31 citations

Mechanism of Catalysis by Eukaryotic DNA Topoisomerase I

1994 • 30 citations

The DNA Binding, Cleavage, and Religation Reactions of Eukaryotic Topoisomerases I and II

1994 • 28 citations

Subcellular distribution of the α and β topoisomerase II-DNA complexes stabilized by VM-26

1994 • 24 citations

Novel actions of inhibitors of DNA topoisomerase II in drug-resistant tumor cells

1994 • 24 citations

Factors affecting human autopsy kidney-cortex and kidney-medulla platinum concentrations after cisplatin administration

1994 • 19 citations

DNA topoisomerases

1991 • 16 citations

Deletion and duplication sequences induced in CHO cells by teniposide (VM-26), a topoisomerase II targeting drug, can be explained by the processing of DNA nicks produced by the drug-topoisomerase interaction

1994 • 10 citations