ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

The scanning model for translation: an update.

1989 • 3,525 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

A general method ofin vitropreparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

1988 • 2,410 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Complementary DNA Sequencing: Expressed Sequence Tags and Human Genome Project

1991 • 2,286 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Apoptosis

1993 • 972 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Structure and mechanism of interleukin-lβ converting enzyme

1994 • 842 citations

Sequence identification of 2,375 human brain genes

1992 • 764 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

1994 • 567 citations

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

1990 • 533 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.

1995 • 407 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

The cell-death machine

1996 • 351 citations

A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.

1995 • 313 citations

Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases

1995 • 281 citations

Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases

1995 • 262 citations

Requirement of an ICE-Like Protease for Induction of Apoptosis and Ceramide Generation by REAPER

1996 • 262 citations

Granzyme B Is Inhibited by the Cowpox Virus Serpin Cytokine Response Modifier A

1995 • 238 citations

Identification and Characterization of CPP32/Mch2 Homolog 1, a Novel Cysteine Protease Similar to CPP32

1996 • 223 citations

Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

1996 • 175 citations

Rapid Purification of Cationic Granule Proteases: Application to Human Granzymes

1993 • 66 citations