Low-dose-melphalan-induced up-regulation of type-1 cytokine expression in the s.c. tumor nodule of MOPC-315 tumor bearers and the role of interferon γ in the therapeutic outcome

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10

1992 • 516 citations

Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.

1987 • 497 citations

Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing.

1983 • 447 citations

IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis.

1995 • 427 citations

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

1994 • 365 citations

Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha.

1995 • 348 citations

Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10

1990 • 347 citations

Constructing polycompetitor cDNAs for quantitative PCR

1993 • 323 citations

Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta).

1991 • 309 citations

The role of IFN-gamma in delayed-type hypersensitivity mediated by Th1 clones.

1989 • 304 citations

Human B-cell interleukin-10: B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10 [see comments]

1992 • 247 citations

Effect of cloned interferon‐γ on expression of H‐2 and Ia antigens on cell lines of hemopoietic, lymphoid, epithelial, fibroblastic and neuronal origin

1984 • 192 citations

Transforming growth factor-beta inhibits the generation of cytotoxic T cells in virus-infected mice.

1989 • 164 citations

Immunosuppressive Factors in Human Cancer

1992 • 131 citations

Cooperation between cyclophosphamide tumoricidal activity and host antitumor immunity in the cure of mice bearing large MOPC-315 tumors.

1981 • 100 citations

The effects of a monoclonal antibody to interferon‐γ on experimental autoimmune thyroiditis (EAT): prevention of disease and decrease of EAT‐specific T cells

1993 • 89 citations

Effects of interferon-γ on the activation of human T lymphocytes

1988 • 82 citations

Analysis of MRP mRNA in mitoxantrone-selected, multidrug-resistant human tumor cells

1994 • 74 citations

Expression of cytokine mRNA in human melanoma tissues

1995 • 73 citations

Obligatory role of IFN-gamma in induction of lymphokine-activated and T lymphocyte killer activity, but not in boosting of natural cytotoxicity.

1988 • 70 citations

The effect of cytokines and chemotactic agonists on the migration of T lymphocytes into skin.

1992 • 61 citations

Monoclonal antibodies to interferon-gamma inhibit interleukin 2-dependent induction of growth and maturation in lectin/antigen-reactive cytolytic T lymphocyte precursors.

1986 • 61 citations

Increase in the effectiveness of melphalan therapy with progression of MOPC-315 plasmacytoma tumor growth

1983 • 60 citations

Induction of TH1- and TH2-associated cytokine mRNA in mouse bladder following intravesical growth of the murine bladder tumor MB49 and BCG immunotherapy

1994 • 56 citations

Low-dose melphalan-induced shift in the production of a Th2-type cytokine to a Th1-type cytokine in mice bearing a large MOPC-315 tumor

1994 • 55 citations

Transforming growth factor-?-mediated down-regulation of antitumor cytotoxicity of spleen cells from MOPC-315 tumor-bearing mice engaged in tumor eradication following low-dose melphalan therapy

1994 • 37 citations

Immune dysfunction in mice with plasmacytomas. I. Evidence that transforming growth factor-beta contributes to the altered expression of activation receptors on host B lymphocytes.

1991 • 37 citations

Importance of Lyt 2+ T-cells in the curative effectiveness of a low dose of melphalan for mice bearing a large MOPC-315 tumor.

1989 • 36 citations

Importance of tumor-specific cytotoxic CD8+ T-cells in eradication of a large subcutaneous MOPC-315 tumor following low-dose melphalan therapy.

1990 • 33 citations

THE INHIBITORY EFFECT OF CYCLOPHOSPHAMIDE-INDUCED MAC-1+ NATURAL SUPPRESSOR CELLS ON IL-2 AND IL-4 UTILIZATION IN MLR

1994 • 32 citations

Lack of an obligate role for IFN-gamma in the primary in vitro mixed lymphocyte response.

1988 • 29 citations

Tumour Growth Causes Suppression of Autoreactive T‐Cell Proliferation by Disrupting Macrophage Responsiveness to Interferon‐γ

1994 • 24 citations

Importance of TNF production for the curative effectiveness of low dose melphalan therapy for mice bearing a large MOPC-315 tumor.

1995 • 22 citations

Involvement of TCR-V beta 8.3+ cells in the cure of mice bearing a large MOPC-315 tumor by low dose melphalan.

1993 • 18 citations

Phorbol ester-induced enhancement in lytic activity of CD8+ splenic T cells from low-dose melphalan-treated MOPC-315-tumor bearers

1991 • 6 citations

Deleted Work

1955 • 0 citations