The role of proteases during apoptosis

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Role of poly(ADP-ribose) formation in DNA repair

1992 • 1,142 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Structure and mechanism of interleukin-lβ converting enzyme

1994 • 842 citations

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

1995 • 767 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Functional Organization Of The Nuclear Envelope

1988 • 593 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

1994 • 567 citations

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

1995 • 539 citations

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

1995 • 524 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Calpain activation in apoptosis

1994 • 445 citations

Apoptosis: molecular mechanisms in programmed cell death.

1991 • 425 citations

Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.

1994 • 424 citations

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.

1995 • 422 citations

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.

1995 • 407 citations

Granzymes: exogenous porteinases that induce target cell apoptosis

1995 • 403 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.

1994 • 352 citations

Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase.

1994 • 345 citations

Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.

1996 • 318 citations

A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.

1995 • 313 citations

Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition.

1996 • 298 citations

Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases

1995 • 262 citations

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1991 • 255 citations

Activation of interleukin‐ 1β by a co‐induced protease

1989 • 254 citations

Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei.

1995 • 242 citations

Granzyme B Is Inhibited by the Cowpox Virus Serpin Cytokine Response Modifier A

1995 • 238 citations

Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.

1992 • 225 citations

Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway.

1995 • 222 citations

PITSLRE protein kinase activity is associated with apoptosis

1995 • 212 citations

Identification of Actin as a Substrate of ICE and an ICE-like Protease and Involvement of an ICE-like Protease but Not ICE in Vp-16-Induced U937 Apoptosis

1995 • 210 citations

Protection from tumor necrosis factor-mediated cytolysis by overexpression of plasminogen activator inhibitor type-2.

1991 • 189 citations

Activation of a Ca²⁺−Mg²⁺‐dependent endonuclease as an early event in castration‐induced prostatic cell death

1988 • 176 citations

Histone shuttling by poly ADP-ribosylation

1994 • 173 citations

Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining.

1992 • 171 citations

Cleavage of Poly(ADP-ribose) Polymerase by Interleukin-1β Converting Enzyme and Its Homologs TX and Nedd-2

1995 • 155 citations

Purification of an Interleukin-1β Converting Enzyme-related Cysteine Protease That Cleaves Sterol Regulatory Element-binding Proteins between the Leucine Zipper and Transmembrane Domains

1995 • 135 citations

Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors.

1994 • 131 citations

Activation of intracellular proteases is an early event in TNF-induced apoptosis.

1995 • 129 citations

The calcium dependent endonuclease activity of isolated nuclear preparations. Relationships between its occurrence and the occurrence of other classes of enzymes found in nuclear preparations

1973 • 127 citations

Apoptotic cell death induced by intracellular proteolysis.

1994 • 124 citations

Ubiquitin pathway involvement in human lymphocyte gamma-irradiation-induced apoptosis.

1993 • 124 citations

Purification and characterization of active human interleukin-1 beta-converting enzyme from THP.1 monocytic cells.

1993 • 111 citations

Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes

1993 • 109 citations

A serine protease inhibitor, protease nexin I, rescues motoneurons from naturally occurring and axotomy-induced cell death.

1995 • 96 citations

Formation of 50 kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation

1994 • 96 citations

Granzyme A binding to target cell proteins. Granzyme A binds to and cleaves nucleolin in vitro

1991 • 93 citations

Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes

1995 • 90 citations

Inhibitors of proteases prevent endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes.

1992 • 86 citations

Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation.

1994 • 81 citations

Protection from tumor necrosis factor cytotoxicity by protease inhibitors

1987 • 75 citations

The human papilloma virus 16E6 gene sensitizes human mammary epithelial cells to apoptosis induced by DNA damage.

1995 • 73 citations

Involvement of a serine protease in tumour‐necrosis‐factor‐mediated cytotoxicity

1988 • 65 citations

Loss of apc protein expressed by human colonic epithelial cells and the appearance of a specific low‐molecular‐weight form is associated with apoptosis IN vitro

1994 • 62 citations

A pre‐existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli

1995 • 53 citations

Phosphorylation and proteolytic degradation of nucleolin from 3T3-F442A cells

1991 • 51 citations

Metabolic effects and kill of human T-cell leukemia by 5-deazaacyclotetrahydrofolate, a specific inhibitor of glycineamide ribonucleotide transformylase.

1992 • 37 citations

Commitment to Cell Death Is Signaled by the Appearance of a Terminin Protein of 30 kDa

1994 • 37 citations

Proteolytic cleavage during chemotherapy-induced apoptosis

1996 • 35 citations

The Use of Ubiquitin as a Marker of Thyroxine-Induced Apoptosis in Cultured Rana catesbeiana Tail Tips

1994 • 20 citations

γ-Irradiated DNA Activates Histone Hl-specific Proteinase of Rat Liver Nuclei

1992 • 18 citations