Ceramide and the induction of apoptosis.

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death*

1993 • 1,005 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia

1990 • 887 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Ceramide activates heterotrimeric protein phosphatase 2A

1993 • 657 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Activation of the Sphingomyelin Cycle Through the Low-Affinity Neurotrophin Receptor

1994 • 583 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Cell death: a new classification separating apoptosis from necrosis

1981 • 575 citations

Apoptosis: a different type of cell death

1992 • 523 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

1991 • 351 citations

Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo.

1994 • 333 citations

Phosphorylation of Raf by ceramide-activated protein kinase

1995 • 332 citations

Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.

1994 • 288 citations

Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells

1993 • 262 citations

CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.

1991 • 258 citations

Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis.

1994 • 255 citations

Radiation-induced Interphase Death of Rat Thymocytes is Internally Programmed (Apoptosis)

1988 • 239 citations

Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase.

1994 • 205 citations

Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by 1-beta-D-arabinofuranosylcytosine.

1991 • 198 citations

1-beta-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells.

1994 • 166 citations

Fumonisins and other inhibitors of de novo sphingolipid biosynthesis.

1993 • 163 citations

Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide.

1995 • 137 citations

Overexpression of Bcl-XL by cytotoxic drug exposure confers resistance to ionizing radiation-induced internucleosomal DNA fragmentation.

1995 • 133 citations

Direct Stimulation of Vav Guanine Nucleotide Exchange Activity for Ras by Phorbol Esters and Diglycerides

1994 • 132 citations

Ceramide Mediates the Apoptotic Response of WEHI 231 Cells to Anti-immunoglobulin, Corticosteroids and Irradiation

1994 • 129 citations

Substrate recognition by ceramide-activated protein kinase. Evidence that kinase activity is proline-directed.

1993 • 124 citations

Glutamate-induced apoptosis results in a loss of striatal neurons in the parkinsonian rat

1994 • 114 citations

Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extracellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway.

1992 • 79 citations

The novel second messenger ceramide: identification, mechanism of action, and cellular activity.

1993 • 56 citations

Regulation of c-jun gene expression in HL-60 leukemia cells by 1-.beta.-D-arabinofuranosylcytosine. Potential involvement of a protein kinase C dependent mechanism

1991 • 54 citations

Signaling mechanisms in T cells.

1991 • 53 citations

The type B receptor for tumor necrosis factor-alpha mediates DNA fragmentation in HL-60 and U937 cells and differentiation in HL-60 cells

1992 • 49 citations

1-beta-D-arabinofuranosylcytosine-diphosphate-choline is formed by the reversal of cholinephosphotransferase and not via cytidylyltransferase.

1992 • 42 citations