Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Developmental cell death: morphological diversity and multiple mechanisms

1990 • 1,695 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Apoptosis induced by anticancer drugs

1992 • 861 citations

Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli

1991 • 816 citations

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

1992 • 685 citations

Death and the cell

1986 • 616 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation.

1993 • 419 citations

Drug-target interactions: only the first step in the commitment to a programmed cell death?

1991 • 412 citations

A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells

1991 • 381 citations

A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

1992 • 379 citations

Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

1990 • 375 citations

The biochemistry of cell death by apoptosis

1990 • 326 citations

Calcium-activated DNA Fragmentation in Rat Liver Nuclei

1989 • 281 citations

Condensation of the chromatin at the membrane of an apoptotic nucleus is not associated with activation of an endonuclease

1993 • 279 citations

Periodicity of DNA folding in higher order chromatin structures.

1990 • 275 citations

Perforin-Mediated Target Cell Lysis by Cytolytic T Lymphocytes

1990 • 268 citations

Active cell death in hormone-dependent tissues

1992 • 264 citations

Cloning of a cDNA for a T Cell-Specific Serine Protease from a Cytotoxic T Lymphocyte

1986 • 247 citations

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

1992 • 243 citations

Hepatocyte apoptosis: Is transforming growth factor-B1 the kiss of death? Oberhammer FA, Pavelka M, Sharma S, Tietenbacher R, Purchio AF, Bursch W, Schulte-Hermann R. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proc Natl Acad Sci USA 1992;89:5408–5412

1993 • 233 citations

Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor

1985 • 231 citations

Detection of the initial stages of DNA fragmentation in apoptosis.

1993 • 228 citations

Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.

1992 • 225 citations

Delayed internucleosomal DNA fragmentation in programmed cell death

1993 • 222 citations

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.

1989 • 186 citations

Identification of a glucocorticoid-induced nuclease in thymocytes. A potential “lysis gene” product.

1987 • 167 citations

Programmed cell death. Activation of lysis by a mechanism involving the synthesis of protein

1969 • 162 citations

Inhibition of human natural cytotoxicity by macromolecular antiproteases.

1981 • 147 citations

Interaction of DNA with nuclear scaffolds in vitro

1988 • 143 citations

Cell structure and DNA organization.

1991 • 133 citations

Possible mechanism of nuclear translocation of proteasomes

1990 • 132 citations

Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes.

1988 • 117 citations

Programmed cell death and apoptosis

1991 • 115 citations

Characterization of three serine esterases isolated from human IL-2 activated killer cells.

1988 • 114 citations

Mechanisms of immune lysis. III. Characterization of the nature and kinetics of the cytotoxic T lymphocyte-induced nuclear lesion in the target.

1982 • 113 citations

Effect of tumor promoters, protease inhibitors, and repair processes on x-ray-induced sister chromatid exchanges in mouse cells.

1979 • 104 citations

Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes.

1986 • 91 citations

The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors.

1991 • 87 citations

Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases.

1992 • 75 citations

Glucocorticoid-induced cell-size changes and nuclear fragility in rat thymocytes

1981 • 63 citations

How to kill cancer cells: membranes and cell signaling as targets in cancer chemotherapy.

1990 • 54 citations

Destruction of the nuclear morphology of thymic lymphocytes by the corticosteroid cortisol

1968 • 48 citations

The mechanism of human NK cell-mediated cytotoxicity. Mode of action of surface-associated proteases in the early stages of the lytic reaction.

1985 • 45 citations

Ca(2+)-regulated serine protease associated with the nuclear scaffold.

1992 • 45 citations

Inhibition of H-ras oncogene transformation of NIH3T3 cells by protease inhibitors.

1987 • 37 citations

Dissolution of the condensed chromatin structures of isolated thymocyte nuclei and the disruption of deoxyribonucleoprotein by inorganic phosphate and a phosphoprotein

1968 • 31 citations

Inhibition of cytotoxic T lymphocyte and natural killer cell-mediated lysis by O,S,S,-trimethyl phosphorodithioate is at an early postrecognition step.

1988 • 22 citations

Chromatin structure. Evidence that the 30-nm fiber is a helical coil with 12 nucleosomes/turn.

1987 • 19 citations

γ-Irradiated DNA Activates Histone Hl-specific Proteinase of Rat Liver Nuclei

1992 • 18 citations