Mechanisms of Neuronal Damage in Brain Hypoxia/Ischemia

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1994 • 3,437 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Delayed neuronal death in the gerbil hippocampus following ischemia

1982 • 2,856 citations

The mitochondrial permeability transition

1995 • 2,412 citations

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death

1990 • 2,204 citations

INTRACELLULAR CALCIUM HOMEOSTASIS

1987 • 2,183 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

1969 • 1,802 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Molecular cloning and characterization of the rat NMDA receptor

1991 • 1,780 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

1991 • 1,465 citations

Ca2 ⁺ Permeability of KA-AMPA—Gated Glutamate Receptor Channels Depends on Subunit Composition

1991 • 1,458 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Effect of anoxia on ion distribution in the brain

1985 • 1,341 citations

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

1990 • 1,234 citations

Sequence and expression of a metabotropic glutamate receptor

1991 • 1,200 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Range of Messenger Action of Calcium Ion and Inositol 1,4,5-Trisphosphate

1992 • 1,144 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Molecular and cellular physiology of intracellular calcium stores

1994 • 1,132 citations

The release and uptake of excitatory amino acids

1990 • 1,090 citations

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1989 • 1,087 citations

The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina

1957 • 1,061 citations

Elementary and global aspects of calcium signalling.

1997 • 1,031 citations

Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists

1988 • 983 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Permeation and block of N‐methyl‐D‐aspartic acid receptor channels by divalent cations in mouse cultured central neurones.

1987 • 934 citations

Structure-activity relationships in the development of excitatory ammo acid receptor agonists and competitive antagonists

1990 • 905 citations

The TINS/TiPS Lecture the molecular biology of mammalian glutamate receptor channels

1993 • 882 citations

Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine

1996 • 868 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

Role of Ca2+ in toxic cell killing

1989 • 856 citations

Nonvesicular release of neurotransmitter

1993 • 837 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 826 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Metabotropic glutamate receptors in brain function and pathology

1993 • 799 citations

Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity

1996 • 768 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 751 citations

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

1990 • 738 citations

Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake

1990 • 728 citations

Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants

1996 • 699 citations

Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury

1993 • 694 citations

Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier.

1992 • 692 citations

Differences in Ca2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression

1994 • 661 citations

Structure and function of the NMDA receptor channel

1995 • 645 citations

Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA

1991 • 638 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Increased damage after ischemic stroke in patients with hyperglycemia with or without established diabetes mellitus

1983 • 633 citations

Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca²⁺ Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons

1995 • 616 citations

Relationship between configuration, function, and permeability in calcium-treated mitochondria.

1976 • 610 citations

Mitochondrial Depolarization in Glutamate-Stimulated Neurons: An Early Signal Specific to Excitotoxin Exposure

1996 • 610 citations

A Molecular Determinant for Submillisecond Desensitization in Glutamate Receptors

1994 • 607 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase

1997 • 588 citations

Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4

1993 • 585 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

1993 • 569 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons

1990 • 553 citations

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

1993 • 543 citations

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

1994 • 527 citations

Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites

1983 • 522 citations

Calcium transport and buffering in neurons

1988 • 519 citations

Mitochondria and programmed cell death: back to the future

1996 • 508 citations

Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones.

1990 • 498 citations

Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons

1994 • 494 citations

Mitochondrial calcium transport

1982 • 486 citations

Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death.

1989 • 484 citations

Electrophysiological studies of NMDA receptors

1987 • 483 citations

Ions and energy in mammalian brain

1994 • 470 citations

Control of apoptosis by the cellular ATP level

1996 • 465 citations

Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro

1985 • 464 citations

Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia

1994 • 462 citations

Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells

1991 • 461 citations

Interactions of Cyclophilin with the Mitochondrial Inner Membrane and Regulation of the Permeability Transition Pore, a Cyclosporin A-sensitive Channel

1996 • 460 citations

AMPA and kainate receptors

1995 • 460 citations

Modulation of the N-methyl-D-aspartate channel by extracellular H+.

1990 • 458 citations

Determinants of ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: Diversity by RNA editing

1993 • 453 citations

Mitochondria, Calcium Regulation, and Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

1996 • 443 citations

Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?

1996 • 437 citations

Control by Asparagine Residues of Calcium Permeability and Magnesium Blockade in the NMDA Receptor

1992 • 437 citations

Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca²⁺

1996 • 421 citations

Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons

1992 • 416 citations

Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro.

1990 • 410 citations

The early events of oxygen and glucose deprivation: setting the scene for neuronal death?

1994 • 401 citations

Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration

1993 • 396 citations

The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria

1978 • 380 citations

The glial cell glutamate uptake carrier countertransports pH-changing anions

1992 • 372 citations

The NMDA Receptor

1995 • 356 citations

Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis.

1996 • 353 citations

Dominant Role of Mitochondria in Clearance of Large Ca2+ Loads from Rat Adrenal Chromaffin Cells

1996 • 352 citations

The inhibition of mitochondrial calcium transport by lanthanides and Ruthenium Red

1974 • 351 citations

The Sodium‐Induced Efflux of Calcium from Heart Mitochondria

1976 • 350 citations

A Reevaluation of the Role of Mitochondria in Neuronal Ca²⁺ Homeostasis

1996 • 347 citations

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

1997 • 345 citations

Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations

1990 • 343 citations

Ca2+-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons

1992 • 336 citations

Function and molecular aspects of biomembrane transport

1981 • 333 citations

Involvement of Free Radicals in Excitotoxicity In Vivo

1995 • 325 citations

NMDA receptors: from genes to channels

1996 • 319 citations

Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria.

1993 • 315 citations

Effects of hypoxia on rat hippocampal neurones in vitro.

1987 • 312 citations

Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents.

1997 • 302 citations

Regulation of neuronal function by calcium

1989 • 302 citations

On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury

1993 • 295 citations

Mitochondria and Na+/Ca2+ exchange buffer glutamate-induced calcium loads in cultured cortical neurons

1995 • 292 citations

Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III

1987 • 288 citations

Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors.

1992 • 284 citations

NMDA Receptor Activation Produces Concurrent Generation of Nitric Oxide and Reactive Oxygen Species: Implications for Cell Death

1995 • 280 citations

Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes

1991 • 277 citations

Methods for antagonizing glutamate neurotoxicity.

1990 • 277 citations

Transport of calcium by mitochondria

1994 • 276 citations

The Cytotoxicity of Tumor Necrosis Factor Depends on Induction of the Mitochondrial Permeability Transition

1996 • 266 citations

Calcium transport and proton electrochemical potential gradient in mitochondria from guinea-pig cerebral cortex and rat heart

1978 • 264 citations

Permeabilization of the inner mitochondrial membrane by Ca2+ ions is stimulated by t-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochondria

1995 • 248 citations

Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca²⁺ is dependent on mitochondrial‐generated reactive oxygen species

1996 • 246 citations

The N-methyl-d-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils

1988 • 246 citations

Mitochondrial permeability transition triggers lymphocyte apoptosis.

1996 • 238 citations

Calcineurin and mitochondrial function in glutamate‐induced neuronal cell death

1996 • 234 citations

Ca2+-dependent and Ca2+- independent glutamate release, energy status and cytosolic free Ca2+ concentration in isolated nerve terminals following metabolic inhibition: Possible relevance to hyoglycaemia and anoxia

1988 • 228 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+.

1993 • 225 citations

Excitatory Amino Acid‐Mediated Cytotoxicity and Calcium Homeostasis in Cultured Neurons

1993 • 219 citations

Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin

1991 • 217 citations

Structural and functional aspects of calcium homeostasis in eukaryotic cells

1990 • 217 citations

Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo

1993 • 216 citations

Evidence for more than one C²⁺ion transport mechanism in mitochondria

1976 • 211 citations

Physiological role of mitochondrial Ca2+ transport

1994 • 209 citations

Reduced ATP concentration as a basis for synaptic transmission failure during hypoxia in the in vitro guinea‐pig hippocampus

1982 • 208 citations

Bench to Bedside: The Glutamate Connection

1992 • 206 citations

Inhibition of Succinate Dehydrogenase by Malonic Acid Produces an “Excitotoxic” Lesion in Rat Striatum

1993 • 206 citations

Neuroprotective Effects of Glutamate Antagonists and Extracellular Acidity

1993 • 202 citations

Calcium transport mechanisms in membrane vesicles from guinea pig brain synaptosomes.

1981 • 200 citations

Ca2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells.

1994 • 194 citations

Calcium-related damage in ischemia

1996 • 193 citations

Intra-ischemic extracellular release of dopamine and glutamate is associated with striatal vulnerability to ischemia

1988 • 191 citations

Evolving Concepts About the Role of Acidosis in Ischemic Neuropathology

1993 • 191 citations

Regulation of Citric Acid Cycle by Calcium

1989 • 187 citations

Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones.

1997 • 185 citations

A Role for Calcium Influx in the Regulation of Mitochondrial Calcium in Endothelial Cells

1996 • 183 citations

Regulated release of Ca2+ from respiring mitochondria by Ca2+/2H+ antiport.

1979 • 182 citations

Degradation of Microtubule‐Associated Protein 2 and Brain Spectrin by Calpain: A Comparative Study

1991 • 180 citations

Down-regulation of protein kinase C protects cerebellar granule neurons in primary culture from glutamate-induced neuronal death.

1990 • 179 citations

On the Voltage Dependence of the Mitochondrial Permeability Transition Pore

1997 • 179 citations

Serum and depolarizing agents cause acute neurotoxicity in cultured cerebellar granule cells: role of the glutamate receptor responsive to N-methyl-D-aspartate.

1990 • 176 citations

Glutamate impairs neuronal calcium extrusion while reducing sodium gradient

1994 • 172 citations

N‐Methyl‐d‐Aspartate‐Sensitive Glutamate Receptors Induce Calcium‐Mediated Arachidonic Acid Release in Primary Cultures of Cerebellar Granule Cells

1990 • 171 citations

Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells

1995 • 169 citations

The Quantity of Calcium that Appears to Induce Neuronal Death

1994 • 167 citations

Correspondence

1996 • 164 citations

The Mechanism of Ion Translocation in Mitochondria. 4. Coupling of K+ Efflux with Ca2+ Uptake

1970 • 163 citations

Ca2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells

1994 • 163 citations

Phosphorylation and activation of the Ca(2+)-pumping ATPase of cardiac sarcoplasmic reticulum by Ca2+/calmodulin-dependent protein kinase.

1993 • 163 citations

The regulation of brain mitochondrial calcium-ion transport. The role of ATP in the discrimination between kinetic and membrane-potential-dependent calcium-ion efflux mechanisms

1980 • 161 citations

Glutamate‐Induced Neuronal Death Is Not a Programmed Cell Death in Cerebellar Culture

1993 • 160 citations

Selective RNA editing and subunit assembly of native glutamate receptors

1994 • 158 citations

Changes in extracellular amino acid neurotransmitters produced by focal cerebral ischemia

1990 • 157 citations

Ca²⁺-Permeable AMPA/Kainate and NMDA Channels: High Rate of Ca²⁺Influx Underlies Potent Induction of Injury

1996 • 156 citations

Vicious Cycle Involving Na⁺Channels, Glutamate Release, and NMDA Receptors Mediates Delayed Neurodegeneration through Nitric Oxide Formation

1996 • 154 citations

Ca2+ efflux mechanisms following depolarization evoked calcium transients in cultured rat sensory neurones.

1992 • 153 citations

Altered Calcium Homeostasis in Cells Transformed by Mitochondria from Individuals with Parkinson's Disease

1997 • 151 citations

Electrophysiology of the inner mitochondrial membrane

1994 • 147 citations

Mitochondria Support Inositol 1,4,5-Trisphosphate-mediated Ca2+ Waves in Cultured Oligodendrocytes

1996 • 147 citations

The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A.

1992 • 146 citations

Extracellular Glutamate During Focal Cerebral Ischaemia in Rats: Time Course and Calcium Dependency

1994 • 145 citations

Activation and Desensitization of Hippocampal Kainate Receptors

1997 • 144 citations

Metabotropic Glutamate Receptors

2017 • 143 citations

Kinetics of calcium(2+) ion carrier in rat liver mitochondria

1979 • 143 citations

Role of multiple cellular proteases in the execution of programmed cell death

1995 • 141 citations

The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells

1990 • 140 citations

Re-evaluation of the H+/site ratio of mitochondrial electron transport with the oxygen pulse technique.

1976 • 140 citations

Physiological cytosolic Ca2+ transients evoke concurrent mitochondrial depolarizations.

1994 • 139 citations

Presynaptic receptors and the control of glutamate exocytosis

1996 • 135 citations

Intracellular calcium levels during the period of delayed excitotoxicity

1993 • 132 citations

Cyclosporin inhibits mitochondrial calcium efflux in isolated adult rat ventricular cardiomyocytes

1992 • 132 citations

Discussion

1996 • 131 citations

Novel functions for subtypes of metabotropic glutamate receptors

1994 • 130 citations

Cytoskeletal Breakdown and Apoptosis Elicited by NO Donors in Cerebellar Granule Cells Require NMDA Receptor Activation

1996 • 130 citations

Mechanisms and Effects of Intracellular Calcium Buffering on Neuronal Survival in Organotypic Hippocampal Cultures Exposed to Anoxia/Aglycemia or to Excitotoxins

1997 • 129 citations

Interactions between Ca2+ mobilizing mechanisms in cultured rat cerebellar granule cells.

1992 • 128 citations

Role of ATP‐sensitive K+ channels during anoxia: major differences between rat (newborn and adult) and turtle neurons.

1992 • 125 citations

The Role of Phosphate in the Regulation of the Independent Calcium‐Efflux Pathway of Liver Mitochondria

1982 • 124 citations

Effects of metabolic blockade on the regulation of intracellular calcium in dissociated mouse sensory neurones.

1990 • 123 citations

Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies.

1994 • 122 citations

Physiological and bioenergetic aspects of mitochondrial calcium transport

1983 • 122 citations

Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons

1995 • 118 citations

Glutamate-induced destabilization of intracellular calcium concentration homeostasis in cultured cerebellar granule cells: role of mitochondria in calcium buffering.

1995 • 113 citations

Neurotoxicity of HIV coat protein gp120, NMDA receptors, and protein kinase C: A study with rat cerebellar granule cell cultures

1993 • 113 citations

Excitatory amino acid neurotoxicity at the N-methyl-d-aspartate receptor in cultured neurons: pharmacological characterization

1989 • 111 citations

Attenuation of Excitatory Amino Acid Toxicity by Metabotropic Glutamate Receptor Agonists and Aniracetam in Primary Cultures of Cerebellar Granule Cells

1993 • 109 citations

A comparison of excitatory amino acid antagonists acting at primary afferent C fibres and motoneurones of the isolated spinal cord of the rat

1987 • 109 citations

Hydrogen ion buffering during complete brain ischemia

1985 • 107 citations

Calcium green-5N, a novel fluorescent probe for monitoring high intracellular free Ca2+ concentrations associated with glutamate excitotoxicity in cultured rat brain neurons

1993 • 106 citations

Changes in Extracellular Amino Acids and Spontaneous Neuronal Activity During Ischemia and Extended Reflow in the CA1 of the Rat Hippocampus

1991 • 104 citations

A Role for the Mitochondrion in the Protection of Cells Against Calcium Overload?

1985 • 103 citations

Properties of neuroprotective cell-permeant Ca2+ chelators: effects on [Ca2+]i and glutamate neurotoxicity in vitro

1994 • 101 citations

An Evaluation of the Role of Calcium in Cell Injury

1995 • 95 citations

Selective blockade of non-NMDA receptors does not block rapidly triggered glutamate-induced neuronal death

1991 • 91 citations

Glutamate Induces a Calcineurin‐Mediated Dephosphorylation of Na⁺,K⁺‐ATPase that Results in Its Activation in Cerebellar Neurons in Culture

1996 • 90 citations

Cl‐ and Na+ homeostasis during anoxia in rat hypoglossal neurons: intracellular and extracellular in vitro studies.

1992 • 90 citations

Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes

1985 • 89 citations

Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures.

1994 • 88 citations

Neurotoxic glutamate treatment of cultured cerebellar granule cells induces Ca²⁺‐dependent collapse of mitochondrial membrane potential and ultrastructural alterations of mitochondria

1996 • 87 citations

The intracellular distribution of calcium

1988 • 85 citations

Extracellular Neuroactive Amino Acids in the Rat Striatum During Ischaemia: Comparison Between Penumbral Conditions and Ischaemia with Sustained Anoxic Depolarisation

1993 • 84 citations

Membrane‐delimited modulation of NMDA currents by metabotropic glutamate receptor subtypes 1/5 in cultured mouse cortical neurons.

1997 • 83 citations

Intrasynaptosomal compartmentation of calcium during depolarization-induced calcium uptake across the plasma membrane

1981 • 83 citations

Calcium and pH in Anoxic and Toxic Injury

1990 • 82 citations

In vitro kainate injury to large, SMI-32(+) spinal neurons is Ca2+ dependent

1995 • 77 citations

Effect of cations and anions on the steady state kinetics of energy-dependent Ca2+ transport in rat liver mitochondria.

1976 • 76 citations

Na(+)-dependent Ca2+ efflux mechanism of heart mitochondria is not a passive Ca2+/2Na+ exchanger

1994 • 75 citations

L-glutamate and acetylcholine mobilise Ca2+ from the same intracellular pool in cerebellar granule cells using transduction mechanisms with different Ca2+ sensitivities

1992 • 74 citations

Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria.

1984 • 74 citations

Cell Swelling, Blebbing, and Death Are Dependent on ATP Depletion and Independent of Calcium During Chemical Hypoxia in a Glial Cell Line (ROC‐1)

1992 • 71 citations

Calcium directly permeates kainate/alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptors in cultured cerebellar Purkinje neurons.

1992 • 70 citations

NMDA Receptor Activation Inhibits Neuronal Volume Regulation after Swelling Induced by Veratridine-Stimulated Na⁺Influx in Rat Cortical Cultures

1996 • 68 citations

The role of NMDA receptors in learning and memory

1995 • 68 citations

Rapid desensitization determines the pharmacology of glutamate neurotoxicity

1994 • 64 citations

Excitatory amino acid‐induced alterations of cytoplasmic free Ca²⁺ individual cerebellar granule neurons: Role in neurotoxicity

1991 • 63 citations

Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate.

1994 • 63 citations

Neurocytotoxicity: pharmacological implications

1991 • 62 citations

The resolution of calcium fluxes in heart and liver mitochondria using the lanthanide series

1979 • 60 citations

In vivo evidence of hydroxyl radical formation induced by elevation of extracellular glutamate after cerebral ischemia in the cortex of anesthetized rats

1996 • 57 citations

Regulation of the intracellular free calcium concentration in acutely dissociated neurones from rat nucleus basalis.

1993 • 55 citations

The binding of Ca2+ ions to pig heart NAD+-isocitrate dehydrogenase and the 2-oxoglutarate dehydrogenase complex

1989 • 54 citations

Superstoichiometric Ca2+ uptake supported by hydrolysis of endogenous ATP in rat liver mitochondria.

1975 • 53 citations

Taxol stabilizes [Ca2+]i and protects hippocampal neurons against excitotoxicity

1995 • 52 citations

Susceptibility of Cerebellar Granule Neurons Derived from Bcl‐2‐Deficient and Transgenic Mice to Cell Death

1997 • 52 citations

The role of early Ca2+ influx in the pathogenesis of delayed neuronal death after brief forebrain ischemia in gerbils

1993 • 52 citations

An Early Loss in Membrane Protein Kinase C Activity Precedes the Excitatory Amino Acid‐Induced Death of Primary Cortical Neurons

1996 • 50 citations

Role of astroglial cells in glutamate homeostasis.

1981 • 50 citations

Glutamate-induced neuronal death in cerebellar culture is mediated by two distinct components: a sodium-chloride component and a calcium component

1994 • 49 citations

The electric charge stoichiometry of respiration-dependent Ca2+ uptake by mitochondria.

1979 • 48 citations

[10] Influence of calcium ions on mammalian intramitochondrial dehydrogenases

1989 • 47 citations

Rapid uncoupling of oxidative phosphorylation accompanies glutamate toxicity in rat cerebellar granule cells

1996 • 47 citations

Protein Kinase C Activation Attenuates N‐Methyl‐<scp>d</scp>‐Aspartate‐Induced Increases in Intracellular Calcium in Cerebellar Granule Cells

1994 • 47 citations

Parallel Antioxidant and Antiexcitotoxic Therapy Improves Outcome After Incomplete Global Cerebral Ischemia in Dogs

1997 • 47 citations

Regulation of calcium homoeostasis in neurons: the role of calcium-binding proteins

1995 • 46 citations

On the origin of a sustained increase in cytosolic Ca²⁺ concentration after a toxic glutamate treatment of the nerve cell culture

1993 • 45 citations

Metabotropic and ionotropic transducers of glutamate signal inversely control cytoplasmic Ca2+ concentration and excitotoxicity in cultured cerebellar granule cells: pivotal role of protein kinase C.

1996 • 44 citations

Ionic basis of membrane potential changes induced by anoxia in rat dorsal vagal motoneurones.

1992 • 44 citations

Mitochondrial free Ca2+ concentration in living cells

1994 • 43 citations

A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture

1991 • 42 citations

Pathological Phosphorylation Causes Neuronal Death: Effect of Okadaic Acid in Primary Culture of Cerebellar Granule Cells

1992 • 37 citations

Dual effect of spermine on mitochondrial Ca2+ transport

1992 • 35 citations

Regulation of cytosolic free calcium concentration by intrasynaptic mitochondria.

1992 • 33 citations

5-(N-ethyl-N-isopropyl)amiloride and mild acidosis protect cultured cerebellar granule cells against glutamate-induced delayed neuronal death

1992 • 32 citations

Is the mitochondrial Ca²⁺ uniporter a voltage‐modulated transport pathway?

1991 • 31 citations

Macrolide antibiotics protect neurons in culture against theN-methyl-d-aspartate (NMDA) receptor-mediated toxicity of glutamate

1993 • 30 citations

Cyclosporine A protects mitochondria in an in vitro model of hypoxia/reperfusion injury

1993 • 29 citations

Effects of glucagon and Na+ on the control of extramitochondrial free Ca2+ concentration by mitochondria from liver and heart

1980 • 27 citations

On the probabilistic nature of excitotoxic neuronal death in hippocampal neurons

1995 • 27 citations

Resuscitation of Brain Neurons in the Presence of Ca²⁺ After Toxic NMDA‐Receptor Activity

1995 • 26 citations

The NMDA receptor, its channel, and its modulation by glycine

1995 • 26 citations

Glutamate- and AMPA-mediated calcium influx through glutamate receptor channels in medial septal neurons

1993 • 25 citations

Ruthenium red protects against glutamate-induced neuronal death in cerebellar culture

1995 • 24 citations

Anatomical, pharmacological, and molecular diversity of native NMDA receptor subtypes

1995 • 24 citations

A Prototypic Intracellular Calcium Antagonist, TMB‐8, Protects Cultured Cerebellar Granule Cells Against the Delayed, Calcium‐Dependent Component of Glutamate Neurotoxicity

1996 • 22 citations

Effects of Ca2+ channel antagonist subtypes on mitochondrial Ca2+ transport

1995 • 21 citations

Rapid purification of pig heart NAD+-isocitrate dehydrogenase. Studies on the regulation of activity by Ca2+, adenine nucleotides, Mg2+ and other metal ions

1989 • 21 citations

Molecular biology of NMDA receptors

1995 • 17 citations

Energy coupling in electron transport.

1967 • 11 citations

TPA for acute ischemic stroke.

1997 • 10 citations