Regulation of cytosolic free calcium concentration by intrasynaptic mitochondria.

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures

1980 • 2,218 citations

INTRACELLULAR CALCIUM HOMEOSTASIS

1987 • 2,183 citations

Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores

1989 • 1,616 citations

Calcium Channels, Stores, and Oscillations

1990 • 1,208 citations

Photochemically generated cytosolic calcium pulses and their detection by fluo-3

1989 • 820 citations

Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse

1991 • 638 citations

Calcium ions, active zones and synaptic transmitter release

1988 • 609 citations

Structure of Biological Membranes

1966 • 545 citations

Calcium transport and buffering in neurons

1988 • 519 citations

Mitochondrial calcium transport

1982 • 486 citations

Neutral carrier ion-selective microelectrodes for measurement of intracellular free calcium

1980 • 474 citations

A rapid method for the preparation of relatively pure metabolically competent synaptosomes from rat brain

1978 • 464 citations

Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro.

1990 • 410 citations

Energy transduction in intact synaptosomes. Influence of plasma-membrane depolarization on the respiration and membrane potential of internal mitochondria determined in situ

1980 • 391 citations

The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria

1978 • 380 citations

Subcellular Calcium Transients Visualized by Confocal Microscopy in a Voltage-Clamped Vertebrate Neuron

1990 • 341 citations

Differential release of amino acids, neuropeptides, and catecholamines from isolated nerve terminals

1991 • 330 citations

Use of fluo-3 to measure cytosolic Ca2+ in platelets and neutrophils. Loading cells with the dye, calibration of traces, measurements in the presence of plasma, and buffering of cytosolic Ca2+

1990 • 303 citations

Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons

1988 • 281 citations

Ca2+ homeostasis in permeabilized human neutrophils. Characterization of Ca2+-sequestering pools and the action of inositol 1,4,5-triphosphate.

1984 • 266 citations

Intracellular calcium concentrations during "chemical hypoxia" and excitotoxic neuronal injury

1991 • 265 citations

Regulation of calcium homeostasis in sensory neurons by bradykinin

1988 • 257 citations

Identification of intracellular calcium pools. Selective modification by thapsigargin

1991 • 238 citations

[8] Application of inhibitors and uncouplers for a study of oxidative phosphorylation

1967 • 237 citations

Cytosolic Free Magnesium Levels in Ischemic Rat Heart

1989 • 230 citations

Anti-immunoglobulin, cytoplasmic free calcium, and capping in B lymphocytes.

1982 • 223 citations

2,5‐Di(tert‐butyl)‐1,4‐benzohydroquinone — a novel inhibitor of liver microsomal Ca²⁺ sequestration

1987 • 204 citations

Neuronal calcium homeostasis

1987 • 189 citations

Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells

1984 • 184 citations

Spermine. A regulator of mitochondrial calcium cycling.

1984 • 181 citations

The regulation of brain mitochondrial calcium-ion transport. The role of ATP in the discrimination between kinetic and membrane-potential-dependent calcium-ion efflux mechanisms

1980 • 161 citations

Freeze-fracture identification of sterol-digitonin complexes in cell and liposome membranes.

1978 • 161 citations

The effect of pH on rate constants, ion selectivity and thermodynamic properties of fluorescent calcium and magnesium indicators

1991 • 160 citations

Synaptosomal bioenergetics

1986 • 149 citations

The effects of pH and temperature on fluorescent calcium indicators as determined with Chelex-100 and EDTA buffer systems

1990 • 139 citations

Characterization of a H+-ATPase in rat brain synaptic vesicles

1989 • 132 citations

Protection by acidotic pH and fructose against lethal injury to rat hepatocytes from mitochondrial inhibitors, ionophores and oxidant chemicals

1990 • 128 citations

Effects of metabolic inhibition on the membrane properties of isolated mouse primary sensory neurones.

1990 • 124 citations

Effects of metabolic blockade on the regulation of intracellular calcium in dissociated mouse sensory neurones.

1990 • 123 citations

Measurement of intrasynaptosomal free calcium by using the fluorescent indicator quin-2

1984 • 111 citations

Inositol 1,4,5-trisphosphate-triggered Ca2+ release from bovine adrenal medullary secretory vesicles.

1990 • 110 citations

Intracellular Calcium Homeostasis

1987 • 100 citations

[4] Firefly luciferase assay for ATP production by mitochondria

1978 • 99 citations

Intracellular levels and distribution of Ca2+ in digitonin-permeabilized cells

1985 • 97 citations

Subcellular distribution of enzymes determined by rapid digitonin fractionation of isolated hepatocytes

1980 • 96 citations

Involvement of mitochondria in the age-dependent decrease in calcium uptake of rat brain synaptosomes

1986 • 93 citations

Membrane depolarization evokes neurotransmitter release in the absence of calcium entry

1989 • 90 citations

Inhibitors of calcium buffering depress evoked transmitter release at the squid giant synapse.

1985 • 90 citations

Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes

1985 • 89 citations

INTERRELATIONS BETWEEN POLYAMINES AND NUCLEIC ACIDS: CHANGES OF POLYAMINE AND NUCLEIC ACID CONCENTRATIONS IN THE DEVELOPING RAT BRAIN

1975 • 87 citations

The regulation of cytosolic calcium in rat brain synaptosomes by sodium‐dependent calcium efflux.

1986 • 86 citations

The intracellular distribution of calcium

1988 • 85 citations

Different calcium pools in human platelets and their role in thromboxane A2 formation.

1991 • 81 citations

Ca²⁺‐Dependent Regulation of Presynaptic Stimulus‐Secretion Coupling

1989 • 77 citations

Interactions between spermine and Mg2+ on mitochondrial Ca2+ transport.

1986 • 76 citations

Polyamines Stimulate Mitochondrial Calcium Transport in Rat Brain

1987 • 76 citations

Cytosolic free calcium levels increase with age in rat brain synaptosomes

1988 • 74 citations

Ionophore A23187, Verapamil, Protonophores, and Veratridine Influence the Release of γ‐Aminobutyric Acid from Synaptosomes by Modulation of the Plasma Membrane Potential Rather than the Cytosolic Calcium

1984 • 72 citations

Thyrotropin-releasing hormone mobilizes Ca2+ from endoplasmic reticulum and mitochondria of GH3 pituitary cells: characterization of cellular Ca2+ pools by a method based on digitonin permeabilization.

1982 • 71 citations

Modulation of intracellular free Ca2+ concentration by IP3-sensitive and IP3-insensitive nonmitochondrial Ca2+ pools

1989 • 71 citations

Activity-dependent accumulation of calcium in Purkinje cell dendritic spines.

1988 • 71 citations

[1] Membrane transport of calcium: An overview

1988 • 67 citations

Calcium Channels, Stores, And Oscillations

1990 • 65 citations

Regulation of Ca2+ transport in brain mitochondria. I. The mechanism of spermine enhancement of Ca2+ uptake and retention

1990 • 60 citations

Evaluation of the Ca²⁺ Concentration in Purified Nerve Terminals: Relationship Between Ca²⁺ Homeostasis and Synaptosomal Preparation

1988 • 60 citations

ATP-dependent regulation of cytoplasmic free calcium in nerve terminals

1987 • 56 citations

Control of cytosolic free calcium by intracellular organelles in bovine adrenal glomerulosa cells. Effects of sodium and inositol 1,4,5-trisphosphate.

1987 • 55 citations

Regulation of Ca2+ transport in brain mitochondria. II. The mechanism of the adenine nucleotides enhancement of Ca2+ uptake and retention

1990 • 55 citations

Relation of Acetylcholine Release to Ca²⁺ Uptake and Intraterminal Ca²⁺ Concentration in Guinea‐Pig Cortex Synaptosomes

1987 • 54 citations

Intracellular acidosis protects cultured hepatocytes from the toxic consequences of a loss of mitochondrial energization

1989 • 51 citations

Caffeine-sensitive calcium stores in presynaptic nerve endings: A physiological role?

1989 • 45 citations

Distribution of calcium and potassium in presynaptic nerve terminals from cerebellar cortex.

1987 • 45 citations

Differential effects of age on the pathways of calcium influx into nerve terminals

1987 • 41 citations

Calcium signalling

1990 • 39 citations

FCCP releases Ca2+ from a non-mitochondrial store in an identifiedHelisoma neuron

1991 • 36 citations

Calcium mobilization in human platelets by receptor agonists and calcium‐ATPase inhibitors

1991 • 34 citations

Adenine nucleotides regulate Ca²⁺ transport in brain mitochondria

1989 • 34 citations

Mitochondrial calcium and cellular electrolytes in brain cortex frozen in situ: Electron probe analysis

1985 • 33 citations

Control of mitochondrial matrix calcium: Studies using fluo-3 as a fluorescent calcium indicator

1990 • 33 citations

Heterogeneity of calcium compartmentation: Electron probe analysis of renal tubules

1986 • 33 citations

Characteristics of Mg2+-dependent, ATP-activated Ca2+ transport in synaptic and microsomal membranes and in permeabilized synaptosomes.

1987 • 31 citations

Allosteric Activation off Brain Mitochondrial Ca²⁺ Uptake by Spermine and by Ca²⁺: Developmental Changes

1989 • 25 citations

The role of ADP in the modulation of the calcium-efflux pathway in rat brain mitochondria

1985 • 24 citations

Developmental changes in mouse brain polyamine metabolism

1982 • 20 citations

Allosteric Activation of Brain Mitochondrial Ca²⁺ Uptake by Spermine and ty Ca²⁺: Brain Regional Differences

1989 • 16 citations

Effects of Diltiazem on Bioenergetics, K⁺ Gradients, and Free Cytosolic Ca²⁺ Levels in Rat Brain Synaptosomes Submitted to Energy Metabolism Inhibition and Depolarization

1989 • 13 citations