Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures

1980 • 2,218 citations

Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action

1971 • 1,400 citations

A non-disruptive technique for loading calcium buffers and indicators into cells

1981 • 1,121 citations

The role of calcium in the release of neurotransmitter substances and hormones.

1970 • 871 citations

The release of neural transmitter substances

1970 • 685 citations

Specific inhibition of mitochondrial Ca++ transport by ruthenium red

1971 • 616 citations

Effects of potassium, veratridine, and scorpion venom on calcium accumulation and transmitter release by nerve terminals in vitro.

1975 • 559 citations

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

1972 • 519 citations

Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids

1974 • 492 citations

Mitochondrial calcium transport

1982 • 486 citations

Free cytoplasmic calcium concentration and the mitogenic stimulation of lymphocytes.

1983 • 466 citations

The Interrelations between the Transport of Sodium and Calcium in Mitochondria of Various Mammalian Tissues

1978 • 402 citations

Energy transduction in intact synaptosomes. Influence of plasma-membrane depolarization on the respiration and membrane potential of internal mitochondria determined in situ

1980 • 391 citations

Membrane potentials in pinched‐off presynaptic nerve ternimals monitored with a fluorescent probe: evidence that synaptosomes have potassium diffusion potentials.

1975 • 389 citations

The release of acetylcholine from nerve endings by graded electric pulses

1967 • 356 citations

The effect of ruthenium red on Ca2+ transport and respiration in rat liver mitochondria

1972 • 321 citations

Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria

1980 • 292 citations

Calcium transport and proton electrochemical potential gradient in mitochondria from guinea-pig cerebral cortex and rat heart

1978 • 264 citations

Effects of veratrum alkaloids on membrane potential and conductance of squid and crayfish giant axons.

1973 • 252 citations

Decreased synthesis of acetylcholine accompanying impaired oxidation of pyruvic acid in rat brain minces

1975 • 242 citations

Involvement of calcium in exocytosis and the exocytosis--vesiculation sequence.

1974 • 186 citations

Evoked transient intracellular free Ca ²⁺ changes and secretion in isolated bovine adrenal medullary cells

1983 • 177 citations

Synaptic Phosphoproteins: Specific Changes After Repetitive Stimulation of the Hippocampal Slice

1979 • 162 citations

Function of calcium ions in pyruvate dehydrogenase phosphatase activity

1972 • 157 citations

Regulation of Mammalian Pyruvate Dehydrogenase Complex by a Phosphorylation–Dephosphorylation Cycle

1981 • 153 citations

Free cytoplasmic Ca2+ and neurotransmitter release: studies on PC12 cells and synaptosomes exposed to alpha-latrotoxin.

1984 • 142 citations

Relative importance of pyruvate dehydrogenase interconversion and feed-back inhibition in the effect of fatty acids on pyruvate oxidation by rat heart mitochondria

1978 • 130 citations

Ruthenium Red inhibits the activation of pyruvate dehydrogenase caused by positive inotropic agents in the perfused rat heart

1983 • 119 citations

Studies on the effects of coenzyme A-SH: acetyl coenzyme A, nicotinamide adenine dinucleotide: reduced nicotinamide adenine dinucleotide, and adenosine diphosphate: adenosine triphosphate ratios on the interconversion of active and inactive pyruvate dehydrogenase in isolated rat heart mitochondria.

1976 • 117 citations

Measurement of intrasynaptosomal free calcium by using the fluorescent indicator quin-2

1984 • 111 citations

Intrasynaptosomal compartmentation of calcium during depolarization-induced calcium uptake across the plasma membrane

1981 • 83 citations

Biochemical studies of synapses in vitro. II. Potassium transport

1969 • 72 citations

Effect of micromolar concentrations of free Ca2+ ions on pyruvate dehydrogenase interconversion in intact rat heart mitochondria

1981 • 69 citations

Evidence that the 40,000 Mr phosphoprotein influenced by high frequency synaptic stimulation is the alpha subunit of pyruvate dehydrogenase

1981 • 65 citations

Calcium uptake related to K+-depolarization and Na+/Ca2+ exchange in sheep brain synaptosomes

1984 • 65 citations

Effects of Dichloroacetate on Brain Pyruvate Dehydrogenase

1984 • 46 citations

The regulation of pyruvate oxidation during membrane depolarization of rat brain synaptosomes

1980 • 44 citations

Changes in free-calcium levels and pH in synaptosomes during transmitter release

1984 • 44 citations

A comparison of the regulation of pyruvate dehydrogenase in mitochondria from rat brain and liver

1975 • 42 citations

THE CONTROL OF PYRUVATE DEHYDROGENASE IN ISOLATED BRAIN MITOCHONDRIA

1978 • 39 citations

Qualitative measurements of cytosolic calcium ion concentration within isolated Guinea pig nerve endings using entrapped arsenazo III

1983 • 34 citations

Entorhinal Cortex Lesions Induce a Decreased Calcium Transport in Hippocampal Mitochondria

1982 • 28 citations

PYRUVATE DEHYDROGENASE ACTIVATION IN RAT BRAIN CORTICAL SLICES BY ELEVATED CONCENTRATIONS OF EXTERNAL POTASSIUM IONS

1977 • 15 citations

Effects of Dichloroacetate on Brain Tissue Pyruvate Dehydrogenase

1983 • 15 citations