Calcium and pH in Anoxic and Toxic Injury

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Calmodulin Plays a Pivotal Role in Cellular Regulation

1980 • 2,441 citations

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

Calcium and muscle contraction

1968 • 1,745 citations

Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth Muscle

1977 • 1,745 citations

Calcium Dependence of Toxic Cell Death: A Final Common Pathway

1979 • 1,478 citations

Myocardial reperfusion: a double-edged sword?

1985 • 1,355 citations

Microtubule Formation in vitro in Solutions Containing Low Calcium Concentrations

1972 • 1,201 citations

Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiace and skeletal muscles.

1978 • 1,086 citations

An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodide.

1985 • 1,068 citations

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

1982 • 893 citations

Control of cytoplasmic actin gel–sol transformation by gelsolin, a calcium-dependent regulatory protein

1979 • 782 citations

Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesicles

1982 • 681 citations

The role of calcium in cell death

1981 • 637 citations

Xanthine oxidase: biochemistry, distribution and physiology.

1986 • 635 citations

Myocardial calcium and magnesium in acute ischemic injury.

1972 • 628 citations

Regulation of intracellular pH in eukaryotic cells

1988 • 618 citations

Changes of free calcium levels with stages of the cell division cycle

1985 • 591 citations

Bleb Formation in Hepatocytes During Drug Metabolism Is Caused by Disturbances in Thiol and Calcium Ion Homeostasis

1982 • 553 citations

Calcium Channel Blocking Agents in the Treatment of Cardiovascular Disorders. Part II: Hemodynamic Effects and Clinical Applications

1980 • 551 citations

Intracellular pH regulation in the renal proximal tubule of the salamander. Basolateral HCO3- transport.

1983 • 549 citations

Intracellular pH: Its Measurement, Regulation, and Utilization in Cellular Functions.

1982 • 544 citations

Calcium Rises Abruptly and Briefly Throughout the Cell at the Onset of Anaphase

1986 • 541 citations

Inhibition of phospholipase A2 by "lipocortins" and calpactins. An effect of binding to substrate phospholipids.

1987 • 534 citations

Blebbing, free Ca2+ and mitochondrial membrane potential preceding cell death in hepatocytes

1987 • 533 citations

Calcium and Ischemic Injury

1986 • 529 citations

Kinetics of calcium accumulation in acute myocardial ischemic injury.

1972 • 507 citations

Elevation in cytosolic free calcium concentration early in myocardial ischemia in perfused rat heart.

1987 • 496 citations

Mitochondrial calcium transport

1982 • 486 citations

Amphipathic metabolites and membrane dysfunction in ischemic myocardium.

1984 • 445 citations

ATP-dependent Ca++-Extrusion from human red cells

1966 • 445 citations

Myocardial ischemia: the pathogenesis of irreversible cell injury in ischemia.

1981 • 441 citations

Stoichiometry of Respiratory Stimulation, Accumulation of Ca++ and Phosphate, and Oxidative Phosphorylation in Rat Liver Mitochondria

1964 • 441 citations

Hormonal effects on calcium homeostasis in isolated hepatocytes.

1980 • 441 citations

Pathophysiology and pathogenesis of stunned myocardium. Depressed Ca2+ activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts.

1987 • 424 citations

Inositol trisphosphate and diacylglycerol as intracellular second messengers in liver

1985 • 419 citations

Criteria of Viability of Isolated Liver Cells

1975 • 411 citations

Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes

1984 • 411 citations

Accelerated phospholipid degradation and associated membrane dysfunction in irreversible, ischemic liver cell injury

1978 • 409 citations

Effect of reperfusion late in the phase of reversible ischemic injury. Changes in cell volume, electrolytes, metabolites, and ultrastructure.

1985 • 388 citations

Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis

1984 • 376 citations

Effect of a transient period of ischemia on myocardial cells. I. Effects on cell volume regulation.

1974 • 356 citations

Energy-dependent calcium sequestration activity in rat liver microsomes.

1975 • 342 citations

Ischemic tissue injury.

1975 • 336 citations

Effects of internal and external cations and of ATP on sodium-calcium and calcium-calcium exchange in squid axons

1977 • 334 citations

Biology of disease: membrane injury and calcium homeostasis in the pathogenesis of coagulative necrosis.

1982 • 316 citations

The Liver: Biology and Pathobiology

1988 • 309 citations

Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide.

1982 • 303 citations

Elevated Erythrocyte Calcium in Sickle Cell Disease

1973 • 301 citations

Accumulation of unesterified arachidonic acid in ischemic canine myocardium. Relationship to a phosphatidylcholine deacylation-reacylation cycle and the depletion of membrane phospholipids.

1984 • 296 citations

Myocardial contracture and accumulation of mitochondrial calcium in ischemic rabbit heart

1977 • 296 citations

Role of a guanine nucleotide-binding regulatory protein in the hydrolysis of hepatocyte phosphatidylinositol 4,5-bisphosphate by calcium-mobilizing hormones and the control of cell calcium. Studies utilizing aluminum fluoride.

1985 • 290 citations

The effect of chain length and lipid phase transitions on the selective permeability properties of liposomes

1975 • 290 citations

Clathrin-coated vesicles contain an ATP-dependent proton pump.

1983 • 284 citations

Differential, direct effects of H+ on Ca2+-activated force of Skinned fibers from the soleus, cardiac and adductor magnus muscles of rabbits

1978 • 274 citations

Transport of H+ and of ionic weak acids and bases

1983 • 271 citations

Acyl-CoA inhibition of adenine nucleotide translocation in ischemic myocardium

1975 • 267 citations

Mechanism of basolateral membrane H+/OH-/HCO-3 transport in the rat proximal convoluted tubule. A sodium-coupled electrogenic process.

1985 • 266 citations

Extracellular acidosis delays onset of cell death in ATP-depleted hepatocytes

1988 • 265 citations

Phosphate transport into brush-border membrane vesicles isolated from rat small intestine

1976 • 264 citations

The Influence of Hydrogen Ion Concentration on Calcium Binding and Release by Skeletal Muscle Sarcoplasmic Reticulum

1972 • 253 citations

Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death.

1989 • 252 citations

Interaction of the antihypertensive drug felodipine with calmodulin

1981 • 251 citations

Cytoplasmic pH, a key determinant of growth factor‐induced DNA synthesis in quiescent fibroblasts

1985 • 247 citations

The early “pump” failure of the ischemic heart

1969 • 243 citations

Effects of pH on Na+-Ca2+ exchange in canine cardiac sarcolemmal vesicles.

1982 • 242 citations

Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation.

1982 • 240 citations

Effects of nifedipine on myocardial perfusion and ischemic injury in dogs.

1978 • 239 citations

Swelling, reductive stress, and cell death during chemical hypoxia in hepatocytes

1989 • 236 citations

Intracellular free calcium concentration measured with 19F NMR spectroscopy in intact ferret hearts.

1987 • 225 citations

EXPERIMENTAL ACUTE MYOCARDIAL INFARCTION; HISTOLOGIC AND HISTOCHEMICAL STUDIES OF EARLY MYOCARDIAL INFARCTS INDUCED BY TEMPORARY OR PERMANENT OCCLUSION OF A CORONARY ARTERY.

1964 • 223 citations

Intracellular pH in early Xenopus embryos: its effect on current flow between blastomeres.

1980 • 214 citations

Cell surface changes and enzyme release during hypoxia and reoxygenation in the isolated, perfused rat liver.

1983 • 213 citations

Phospholipid alterations in canine ischemic myocardium. Temporal and topographical correlations with Tc-99m-PPi accumulation and an in vitro sarcolemmal Ca2+ permeability defect.

1981 • 213 citations

A high affinity calcium-stimulated magnesium-dependent ATPase in rat liver plasma membranes. Dependence of an endogenous protein activator distinct from calmodulin.

1981 • 212 citations

Intracellular calcium concentration during hypoxia and metabolic inhibition in mammalian ventricular muscle.

1983 • 211 citations

Purification and properties of the NAD+-dependent (type D) and O2-dependent (type O) forms of rat liver xanthine dehydrogenase

1976 • 209 citations

Acidosis during early reperfusion prevents myocardial stunning in perfused ferret hearts.

1988 • 200 citations

Differential effects of phorbol ester on phenylephrine and vasopressin-induced Ca2+ mobilization in isolated hepatocytes.

1985 • 199 citations

The contractile basis of amoeboid movement: V. The control of gelation, solation, and contraction in extracts from dictyostelium discoideum

1977 • 199 citations

Electrolyte Alterations in Acute Myocardial Ischemic Injury

1964 • 199 citations

Effects of Intracellular H+ on the Electrical Properties of Excitable Cells

1984 • 198 citations

Optical microscopy for biology

1991 • 197 citations

Calcium uptake of a rat liver microsomal subcellular fraction in response to in vivo administration of carbon tetrachloride.

1976 • 192 citations

Mitochondrial transmembrane potential and pH gradient during anoxia

1987 • 191 citations

Ischemic myocardial cell injury. Prevention by chlorpromazine of an accelerated phospholipid degradation and associated membrane dysfunction.

1979 • 189 citations

Progress in Liver Diseases

1981 • 186 citations

Regulated release of Ca2+ from respiring mitochondria by Ca2+/2H+ antiport.

1979 • 182 citations

Calcium dependence of glucocorticoid-induced lymphocytolysis.

1977 • 179 citations

Effects of metabolic acidosis on viability of cells exposed to anoxia

1985 • 179 citations

Calcium and Cell Function

1984 • 178 citations

Stimulation of Na:H exchange by insulin

1981 • 177 citations

Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress

1988 • 174 citations

Advances in Cyclic Nucleotide Research

1981 • 173 citations

Heart Muscle Viability following Hypoxia: Protective Effect of Acidosis

1973 • 172 citations

Cytoskeletal damage during myocardial ischemia: changes in vinculin immunofluorescence staining during total in vitro ischemia in canine heart.

1987 • 169 citations

Intra- and extracellular actions of proton on the calcium current of isolated guinea pig ventricular cells.

1986 • 169 citations

Centrilobular Injury Following Hypoxia in Isolated, Perfused Rat Liver

1981 • 169 citations

Inhibition of hepatocyte plasma membrane Ca²⁺‐ATPase activity by menadione metabolism and its restoration by thiols

1985 • 168 citations

Permeability properties of liposomes prepared from dipalmitoyllecithin, dimyristoyllecithin, egg lecithin, rat liver lecithin and beef brain sphingomyelin

1974 • 166 citations

Irreversible injury in anoxic hepatocytes precipitated by an abrupt increase in plasma membrane permeability

1988 • 166 citations

Integration of Mitochondrial Function

1988 • 165 citations

Toxic Injury to Isolated Hepatocytes Is Not Dependent on Extracellular Calcium

1981 • 164 citations

Interaction of calcium antagonists with cyclic AMP phosphodiesterases and calmodulin

1982 • 163 citations

The Action of Vital Stains Belonging to the Benzidine Group

1914 • 157 citations

Calcium-dependent and calcium-independent mechanisms of irreversible cell injury in cultured hepatocytes.

1986 • 149 citations

Cellular mechanisms of urinary acidification.

1974 • 147 citations

Sensitivity to H, Li and Mg ions of the slow inward sodium current in frog atrial fibres

1975 • 143 citations

Active Calcium Transport and Ca2+-Activated ATPase in Human Red Cells

1975 • 142 citations

Myocardial neutrophil accumulation during reperfusion after reversible or irreversible ischemic injury

1988 • 142 citations

Biochemical changes in liver in acute thioacetamide intoxication

1956 • 141 citations

Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress

1988 • 139 citations

Effects of ischaemia and reperfusion on calcium exchange and mechanical function in isolated rabbit myocardium

1981 • 138 citations

Regulation of microfilaments and microtubules by calcium and cyclic AMP.

1979 • 135 citations

Potentiation of oxidative cell injury in hepatocytes which have accumulated Ca2+.

1984 • 133 citations

The multiple roles of glutathione in drug metabolism

1984 • 132 citations

Contractile dysfunction and ATP depletion after transient calcium overload in perfused ferret hearts.

1988 • 130 citations

Carbon-dioxide-induced exocytotic insertion of H+ pumps in turtle-bladder luminal membrane: role of cell pH and calcium

1985 • 129 citations

Protection by acidotic pH and fructose against lethal injury to rat hepatocytes from mitochondrial inhibitors, ionophores and oxidant chemicals

1990 • 128 citations

Mechanisms involved in alpha-adrenergic phenomena

1985 • 127 citations

Calcium uptake during post-ischemic reperfusion in the isolated rat heart: Influence of extracellular sodium

1982 • 127 citations

Calcium dependence of bleb formation and cell death in hepatocytes

1988 • 127 citations

Accelerated phospholipid degradation in anoxic rat hepatocytes

1981 • 124 citations

Cell calcium, vitamin E, and teh thiol redox system in cytocoxicity

1989 • 123 citations

Effects of Ca2+ antagonism on energy metabolism: Ca2+ and heart function after ischemia

1980 • 122 citations

Physiological and bioenergetic aspects of mitochondrial calcium transport

1983 • 122 citations

Microtubule assembly and disassembly at alkaline pH

1981 • 121 citations

Effects of acid-base changes on excitation--contraction coupling in guinea-pig and rabbit cardiac ventricular muscle.

1981 • 120 citations

Relations among sodium pump inhibition, Na-Ca and Na-H exchange activities, and Ca-H interaction in cultured chick heart cells.

1987 • 112 citations

Control and manipulation of calcium movement

1985 • 111 citations

Dependence of cardiac mitochondrial pyruvate dehydrogenase activity on intramitochondrial free Ca2+ concentration

1988 • 110 citations

Toxic injury from mercuric chloride in rat hepatocytes.

1990 • 108 citations

Increase in cytosolic Ca²⁺ concentration during t‐butyl hydroperoxide metabolism by isolated hepatocytes involves NADPH oxidation and mobilization of intracellular Ca²⁺ stores

1984 • 107 citations

Calcium Uptake in Isolated Hepatic Plasma‐Membrane Vesicles

1982 • 107 citations

Ca2+ as a second messenger within mitochondria

1986 • 105 citations

Mitochondrial calcium accumulation and respiration in ischemic acute renal failure in the rat

1984 • 104 citations

Calcium dependency of prostaglandin E2 production in rat glomerular mesangial cells. Evidence that protein kinase C modulates the Ca2+-dependent activation of phospholipase A2.

1988 • 103 citations

New, simple models to evaluate zone-specific damage due to hypoxia in the perfused rat liver: time course and effect of nutritional state.

1986 • 103 citations

Cytosolic‐free Ca ²⁺ and cell killing in hepatoma 1c1c7 cells exposed to chemical anoxia

1989 • 102 citations

The effects of anoxia on cytosolic free calcium, calcium fluxes, and cellular ATP levels in cultured kidney cells.

1985 • 102 citations

Calcium and cell death

1983 • 102 citations

Cell calcium and the control of membrane transport.

1987 • 101 citations

The hydrogen ion-pumping adenosine triphosphatase of platelet dense granule membrane. Differences from F1F0- and phosphoenzyme-type ATPases.

1984 • 101 citations

Effects of extracellular calcium removal and anoxia on isolated rat myocytes

1982 • 94 citations

Cytoskeletal lesions in anoxic myocardial injury. A conventional and high-voltage electron-microscopic and immunofluorescence study.

1987 • 94 citations

Lithium transport by fibroblastic mouse cells: Characterization and stimulation by serum and growth factors in quiescent cultures

1978 • 93 citations

On the relationship between Ca²⁺ efflux and membrane damage during t‐butylhydroperoxide metabolism by liver mitochondria

1983 • 93 citations

Regulation of cytoplasmic pH by Na+/H+ exchange

1986 • 92 citations

Alterations of ultrastructure and elemental composition in cultured neonatal rat cardiac myocytes after metabolic inhibition with iodoacetic acid.

1985 • 90 citations

Role of chloride/bicarbonate antiport in the control of cytosolic pH. Cell-line differences in activity and regulation of antiport.

1988 • 89 citations

A protective effect of a mild acidosis on hypoxic heart muscle

1979 • 89 citations

Effects of verapamil in models of ischemic acute renal failure in the rat

1983 • 87 citations

Myocardial phospholipase a of microsomal and mitochondrial fractions

1971 • 86 citations

Effects of low extracellular sodium on cytosolic ionized calcium. Na+-Ca2+ exchange as a major calcium influx pathway in kidney cells.

1985 • 85 citations

Differentiation of Ca2+ pumps linked to plasma membrane and endoplasmic reticulum in the microsomal fraction from intestinal smooth muscle

1981 • 85 citations

Evidence for anionic cation transport of lithium, sodium and potassium across the human erythrocyte membrane induced by divalent anions.

1978 • 84 citations

Intracellular pH-regulating mechanism of the squid axon. Relation between the external Na+ and HCO-3 dependences.

1985 • 84 citations

HgCl2-induced changes in cytosolic Ca2+ of cultured rabbit renal tubular cells

1987 • 84 citations

Mitochondrial transmembrane ion distribution during anoxia

1987 • 83 citations

Formation of lysophosphatidyl ethanolamines in cell fractions of rat liver

1966 • 83 citations

Reperfusion and reperfusion injury.

1987 • 82 citations

Role of changes in [Ca2+]i in energy deprivation contracture.

1987 • 80 citations

Calcium and Cell Function

1986 • 80 citations

Cellular necrosis in the liver induced and modified by drugs.

1965 • 78 citations

Mediators of Ischemic Renal Injury

1988 • 78 citations

Mechanisms of cell injury with hepatotoxic chemicals.

1984 • 76 citations

Calcium-induced calcium release from purified cardiac sarcoplasmic reticulum vesicles. General characteristics.

1984 • 75 citations

Cytosolic free magnesium, ATP, and blebbing during chemical hypoxia in cultured rat hepatocytes

1990 • 73 citations

Na+/H+ exchanger activity in the pig kidney epithelial cell line, LLC-PK1: Inhibition by amiloride and its derivatives

1985 • 63 citations

Altered calcium homeostasis in the pathogenesis of myocardial ischemic and hypoxic injury

1988 • 61 citations

Ca2+ transport and Ca2+-dependent ATP hydrolysis by Golgi vesicles from lactating rat mammary glands

1985 • 58 citations

Mechanism of protection by verapamil and nifedipine from anoxic injury in isolated cardiac myocytes

1984 • 55 citations

Ca2+ transporting activity of membrane fractions isolated from the post-mitochondrial supernatant of rat liver

1982 • 54 citations

Platelet‐derived growth factor and angiotensin II cause increases in cytosolic free calcium by different mechanisms in vascular smooth muscle cells

1989 • 53 citations

Galactosamine-induced cell death in primary cultures of rat hepatocytes.

1980 • 52 citations

Synergistic activation of rat hepatocyte glycogen phosphorylase by A23187 and phorbol ester

1984 • 51 citations

Mechanisms of accumulation of arachidonic acid in cultured myocardial cells during ATP depletion

1985 • 50 citations

Effect of α-tocopherol incorporation on glucose permeability and phase transition of lecithin liposomes

1979 • 50 citations

Determinants of hypoxic and posthypoxic myocardial contracture

1977 • 50 citations

Phospholipase A2 from sheep erythrocyte membrane CA2+ dependence and localization

1979 • 47 citations

Advances in protein chemistry

1983 • 47 citations

Irreversible ischemic cell injury. Prevention by chlorpromazine of the aggregation of the intramembranous particles of rat liver plasma membranes.

1978 • 46 citations

Mitochondrial function and intracellular calcium in anoxic cardiac myocytes

1986 • 45 citations

Thiazide diuretic effect on medullary collecting duct function in the rat

1983 • 44 citations

Intracellular sodium‐calcium dissociation in early contractile failure in hypoxic ferret papillary muscles.

1987 • 44 citations

Disappearance of Stabilized Chromatic Gratings

1981 • 41 citations

Measurement of cytosolic calcium with aequorin in dispersed rat ventricular cells

1985 • 39 citations

Basic cellular mechanisms of action of the calcium-channel blockers

1985 • 39 citations

Explosive swelling of myocardial cells irreversibly injured by transient ischemia.

1975 • 38 citations

Kinetic properties of the sodium bicarbonate (carbonate) symport in monkey kidney epithelial cells (BSC-1). Interactions between Na+, HCO-3, and pH.

1986 • 37 citations

Antagonism of calmodulin and phosphodiesterase by nifedipine and related calcium entry blockers

1984 • 34 citations

Heterogeneity of calcium compartmentation: Electron probe analysis of renal tubules

1986 • 33 citations

Cytosolic free calcium concentration in cultured renal epithelial cells

1986 • 31 citations

Biochemical evidence for pharmacological similarities between α-adrenoreceptors and voltage-dependent Na+ and Ca++ channels

1982 • 30 citations

Regulation of cytosolic free calcium concentration in cultured renal epithelial cells

1986 • 30 citations

Altered Ca fluxes and contractile state during pH changes in cultured heart cells

1987 • 28 citations

Calcium overload and mechanical function in posthypoxic myocardium: biphasic effect of pH during hypoxia

1979 • 28 citations

Modulation of K⁺ conductance by intracellular pH in pancreatic β‐cells

1986 • 27 citations

Relationship of cytosolic ion fluxes and protein kinase C activation to platelet-derived growth factor induced competence and growth in BALB/c-3T3 cells

1989 • 27 citations

Plasma membrane changes in freeze-fractured rat kidney cortex following renal ischemia.

1976 • 26 citations

Glucose-induced electrical activity in pancreatic beta-cell: modulation by pH

1981 • 25 citations

Calcium and the mechanisms of liver necrosis.

1982 • 22 citations

Calcium dependence of ionophore A23187-induced lymphocyte cytotoxicity.

1978 • 20 citations

Nerve growth factor does not activate Na⁺/H⁺ exchange in PC12 pheochromocytoma cells

1985 • 20 citations

The role of calcium in the regulation of sugar transport in the pigeon red blood cell.

1983 • 20 citations

Calcium-dependent processes in the liver

1989 • 19 citations

Chlorpromazine inhibits loss of contractile function, compliance and ATP in ischemic rabbit heart

1983 • 19 citations

Determination of isolated myocyte viability: Staining methods and functional criteria

1984 • 18 citations

Phospholipid metabolism of dog liver under hypoxic conditions induced by ligation of the hepatic artery

1981 • 13 citations

The liver plasma membrane Ca2+ pump: Hormonal sensitivity

1985 • 13 citations

Inhibition of early platelet-derived growth factor responses in BALBc-3T3 cells by interferon

1988 • 9 citations

Mitochondrial Calcium Fluxes and Their Role in the Regulation of Intracellular Calcium

1985 • 8 citations

Mechanisms of cell toxicity the thiol calcium hypothesis

1988 • 5 citations

Round Two of Budget Cuts Is Approaching

1981 • 5 citations

Reprints: more for than against

1989 • 1 citations

Reprints: more for than against

1989 • 1 citations

Deleted Work

1955 • 0 citations