Changes in Extracellular Amino Acids and Spontaneous Neuronal Activity During Ischemia and Extended Reflow in the CA1 of the Rat Hippocampus

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

A new model of bilateral hemispheric ischemia in the unanesthetized rat.

1979 • 1,934 citations

Cell Damage in the Brain: A Speculative Synthesis

1981 • 1,827 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Glutamate neurotoxicity in cortical cell culture

1987 • 1,400 citations

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia

1990 • 1,125 citations

Ischemia-Induced Shift of Inhibitory and Excitatory Amino Acids from Intra- to Extracellular Compartments

1985 • 663 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

Experimental cerebral ischemia in Mongolian gerbils

1975 • 642 citations

Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia

1990 • 589 citations

Selective vulnerability in the gerbil hippocampus following transient ischemia

1984 • 562 citations

“Epileptic” brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies

1983 • 554 citations

Brain Microdialysis

1989 • 518 citations

Scope and limitations of in vivo brain dialysis: A comparison of its application to various neurotransmitter systems

1987 • 431 citations

Excitatory amino acid transmission

1987 • 430 citations

In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis

1986 • 428 citations

Determination of Brain Interstitial Concentrations by Microdialysis

1989 • 410 citations

Purine levels in the intact rat brain. Studies with an implanted perfused hollow fibre

1982 • 390 citations

Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures

1990 • 372 citations

The effects of 5-minute ischemia in Mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus

1983 • 356 citations

Extracellular Overflow of Neuroactive Amino Acids During Severe Insulin‐Induced Hypoglycemia: In Vivo Dialysis of the Rat Hippocampus

1986 • 349 citations

Delayed neurotoxicity of excitatory amino acids In vitro

1987 • 332 citations

Regional Energy Balance in Rat Brain After Transient Forebrain Ischemia

1983 • 315 citations

Selective neuron loss after cerebral ischemia in the rat: Possible role of transmitter glutamate

2009 • 305 citations

Mass transfer in brain dialysis devices—a new method for the estimation of extracellular amino acids concentration

1985 • 299 citations

MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period

1988 • 276 citations

Increases in Cerebral Interstitial Fluid Adenosine Concentration during Hypoxia, Local Potassium Infusion, and Ischemia

1986 • 258 citations

Regional Cerebral Glucose Phosphorylation and Blood Flow After Insertion of a Microdialysis Fiber Through the Dorsal Hippocampus in the Rat

1987 • 257 citations

An adenosine agonist inhibits and a cyclic AMP analogue enhances the release of glutamate but not GABA from slices of rat dentate gyrus

1983 • 257 citations

Ischemic Damage in Hippocampal CA1 is Dependent on Glutamate Release and Intact Innervation from CA3

1989 • 249 citations

Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path

1985 • 247 citations

The N-methyl-d-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils

1988 • 246 citations

Mild acidosis protects hippocampal neurons from injury induced by oxygen and glucose deprivation

1990 • 202 citations

Serum and depolarizing agents cause acute neurotoxicity in cultured cerebellar granule cells: role of the glutamate receptor responsive to N-methyl-D-aspartate.

1990 • 176 citations

Prolonged exposure to submicromolar concentrations of quinolinic acid causes excitotoxic damage in organotypic cultures of rat corticostriatal system

1989 • 175 citations

Protection by NMDA Antagonists against Selective Cell Loss following Transient Ischaemia

1990 • 162 citations

Polyamine Changes in Reversible Cerebral Ischemia

1987 • 110 citations

Calcium Uptake Evoked by Electrical Stimulation is Enhanced Postischemically and Precedes Delayed Neuronal Death in CA1 of Rat Hippocampus: Involvement of N-Methyl-D-Aspartate Receptors

1988 • 106 citations

Long-Term Development of Selective Neuronal Loss and the Mechanism of Protection by 2-Amino-7-Phosphonoheptanoate in a Rat Model of Incomplete Forebrain Ischaemia

1988 • 102 citations

Effects of Microdialysis‐Perfusion with Anisoosmotic Media on Extracellular Amino Acids in the Rat Hippocampus and Skeletal Muscle

1989 • 100 citations

The Effects of Dizocilpine Maleate (MK-801), an Antagonist of the N-Methyl-D-Aspartate Receptor, on Neurologic Recovery and Histopathology following Complete Cerebral Ischemia in Primates

1990 • 100 citations

Ischemia-induced changes in the electrical activity of the hippocampus

1989 • 94 citations

The neuroprotective actions of kynurenic acid and MK-801 in gerbils are synergistic and not related to hypothermia

1990 • 93 citations

Rapid down regulation of hippocampal adenosine receptors following brief anoxia

1986 • 90 citations

Cellular and subcellular redistribution of glutamate-, glutamine- and taurine-like immunoreactivities during forebrain ischemia: A semiquantitative electron microscopic study in rat hippocampus

1991 • 86 citations

Polyamines contribute to calcium-stimulated release of aspartate from brain particulate fractions

1986 • 78 citations

MK-801, an Excitatory Amino Acid Antagonist, Does Not Improve Neurologic Outcome following Cardiac Arrest in Cats

1989 • 67 citations

Hippocampal unit activity after transient cerebral ischemia in rats.

1989 • 64 citations

Amelioration of ischaemic brain damage by postischaemic treatment with flunarizine^*

1985 • 61 citations

Evaluation of the glutamate antagonist dizocilipine maleate (MK-801) on neurologic outcome in a canine model of complete cerebral ischemia: correlation with hippocampal histopathology

1989 • 56 citations

Control of glial cell volume in anoxia. In vitro studies on ischemic cell swelling.

1987 • 56 citations

Liquid Chromatographic Determination of Amino Acids After Precolumn Fluorescence Derivatization

2003 • 54 citations

Transformation of Postischemic Perineuronal Glial Cells. I. Electron Microscopic Studies

1986 • 53 citations

Dialytrode Technology and Local Profiles of Amino Acids in the Awake Cat Brain

1984 • 53 citations

Cysteine Sulfinic Acid in the Central Nervous System: Uptake and Release of Cysteine Sulfinic Acid by a Rat Brain Preparation

1982 • 52 citations

Extracellular Acidic Sulfur‐Containing Amino Acids and γ‐Glutamyl Peptides in Global Ischemia: Postischemic Recovery of Neuronal Activity Is Paralleled by a Tetrodotoxin‐Sensitive Increase in Cysteine Sulfinate in the CA1 of the Rat Hippocampus

1991 • 50 citations

Chronic cerebral intracellular alkalosis following forebrain ischemic insult in rats.

1990 • 36 citations

Neuroactive Sulphur Amino Acids Evoke a Calcium‐Dependent Transmitter Release from Cultured Neurones That Is Sensitive to Excitatory Amino Acid Receptor Antagonists

1989 • 23 citations

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