Biochemistry of Platelet Activation

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

1998 • 2,047 citations

Integrins and other cell adhesion molecules

1990 • 1,990 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Hematology: Basic Principles and Practice

1991 • 1,907 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Nomenclature and classification of purinoceptors.

1994 • 1,569 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

Handbook of Neurochemistry

1972 • 1,374 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.

1985 • 968 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

The selecting: vascular adhesion molecules

1995 • 954 citations

Molecular mechanisms of platelet activation.

1989 • 903 citations

A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation.

1985 • 886 citations

Selectins.

1993 • 869 citations

G PROTEIN βγ SUBUNITS

1997 • 834 citations

Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin

1985 • 824 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Adenosine Diphosphate in Red Cells as a Factor in the Adhesiveness of Human Blood Platelets

1961 • 781 citations

Protein Lipidation in Cell Signaling

1995 • 771 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium

1987 • 765 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

Production of diglyceride from phosphatidylinositol in activated human platelets.

1979 • 727 citations

Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.

1983 • 705 citations

SH2 and SH3 domains

1993 • 697 citations

Haemostasis and Thrombosis.

1982 • 688 citations

Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

1995 • 673 citations

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

1997 • 671 citations

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.

1992 • 669 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity.

1988 • 663 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

New roles for G-protein (βγ-dimers in transmembrane signalling

1993 • 633 citations

STRUCTURE AND FUNCTION OF SIGNAL-TRANSDUCING GTP-BINDING PROTEINS

1991 • 630 citations

Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate

1987 • 624 citations

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

1995 • 620 citations

Regulation of intracellular pH in eukaryotic cells

1988 • 618 citations

ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding protein

1991 • 604 citations

Changes in membrane phospholipid distribution during platelet activation

1983 • 551 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

1989 • 529 citations

Hematology: Basic Principles and Practice

1995 • 526 citations

Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases

1996 • 524 citations

Calcium oscillations.

1990 • 520 citations

Platelets and Thrombolytic Therapy

1990 • 485 citations

Binding of G protein beta gamma-subunits to pleckstrin homology domains.

1994 • 479 citations

Identification of two lysosomal membrane glycoproteins.

1985 • 475 citations

The Actin-Binding Protein Profilin Binds to PIP ₂ and Inhibits Its Hydrolysis by Phospholipase C

1990 • 472 citations

Rho Family GTPases Bind to Phosphoinositide Kinases

1995 • 469 citations

cDNA cloning and expression of a hamster α‐thrombin receptor coupled to Ca²⁺ mobilization

1991 • 464 citations

Molecular Basis for ADP-induced Platelet Activation

1998 • 463 citations

Platelet-activating factor: receptors and signal transduction

1993 • 459 citations

A monoclonal antibody to a membrane glycoprotein binds only to activated platelets.

1984 • 456 citations

The elemental principles of calcium signaling

1995 • 455 citations

Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation

1995 • 451 citations

cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.

1994 • 451 citations

Platelet alpha-granule proteins: studies on release and subcellular localization

1979 • 451 citations

Molecular Basis for ADP-induced Platelet Activation

1998 • 446 citations

Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits

1993 • 444 citations

Complement Proteins C5b-9 Induce Secretion of High Molecular Weight Multimers of Endothelial von Willebrand Factor and Translocation of Granule Membrane Protein GMP-140 to the Cell Surface

1989 • 442 citations

G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2

1989 • 438 citations

von Willebrand factor and von Willebrand disease [published erratum appears in Blood 1988 Mar;71(3):830]

1987 • 435 citations

A platelet membrane protein expressed during platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin-activated platelets.

1984 • 426 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

The influence on platelet aggregation of drugs that affect the accumulation of adenosine 3′:5′-cyclic monophosphate in platelets

1971 • 422 citations

Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.

1991 • 415 citations

Identification of platelet activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphorylcholine.

1980 • 408 citations

Distribution of decay-accelerating factor in the peripheral blood of normal individuals and patients with paroxysmal nocturnal hemoglobinuria.

1985 • 408 citations

Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders

1988 • 405 citations

A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of platelet activation-dependent granule-external membrane protein.

1986 • 402 citations

Purification and characterization of a membrane protein (gp45-70) that is a cofactor for cleavage of C3b and C4b.

1986 • 401 citations

Handbook of Neurochemistry

1984 • 390 citations

Rho as a regulator of the cytoskeleton

1995 • 386 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts.

1992 • 374 citations

Phosphatidylinositol 3-Kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein Kinase Signaling Pathway

1996 • 372 citations

Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors

1992 • 367 citations

Friends and family: The role of the rab GTPases in vesicular traffic

1993 • 364 citations

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

1992 • 361 citations

Platelet alpha granules contain a growth factor for fibroblasts

1979 • 355 citations

Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP.

1990 • 354 citations

Mechanisms of platelet activation: Thromboxane A2 as an amplifying signal for other agonists

1991 • 349 citations

Calcium Signaling in Human Platelets

1990 • 348 citations

Cellular consequences of thrombin-receptor activation

1996 • 341 citations

Lipid modifications of G proteins: alpha subunits are palmitoylated.

1993 • 336 citations

Activation and depalmitoylation of Gsα

1994 • 336 citations

Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.

1986 • 329 citations

Mediators produced by the endothelial cell.

1988 • 329 citations

A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain.

1988 • 317 citations

The dynamic role of palmitoylation in signal transduction

1995 • 315 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

Biosynthesis of von Willebrand protein by human endothelial cells: processing steps and their intracellular localization.

1984 • 313 citations

The release of nucleotides, 5‐hydroxytryptamine and enzymes from human blood platelets during aggregation

1968 • 312 citations

von Willebrand factor and von Willebrand disease [published erratum appears in Blood 1988 Mar;71(3):830]

1987 • 311 citations

Signal transduction and actin filament organization

1996 • 309 citations

Secretable Storage Pools in Platelets

1979 • 309 citations

Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets.

1993 • 309 citations

Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets.

1985 • 308 citations

Formation of leukotrienes and other hydroxy acids during platelet-neutrophil interactions in vitro

1982 • 308 citations

Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

1992 • 306 citations

Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha.

1993 • 293 citations

Studies with a monoclonal antibody against activated platelets: evidence that a secreted 53,000-molecular weight lysosome-like granule protein is exposed on the surface of activated platelets in the circulation

1987 • 282 citations

Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.

1991 • 281 citations

Functional and Physical Interactions of Syk Family Kinases with the Vav Proto-Oncogene Product

1996 • 281 citations

Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4.

1988 • 278 citations

Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles

1991 • 277 citations

Platelet-derived microparticles express high affinity receptors for factor VIII.

1991 • 277 citations

Studies of the release from human platelets of the growth factor for cultured human arterial smooth muscle cells.

1978 • 271 citations

Phorbol ester-induced activation of human platelets is associated with protein kinase C phosphorylation of myosin light chains

1983 • 265 citations

Decreased adhesion of giant (Bernard-Soulier) platelets to subendothelium

1974 • 265 citations

G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells.

1991 • 263 citations

Platelet-Endothelium Interactions

1993 • 256 citations

Molecular cloning and expression of the major protein kinase C substrate of platelets

1988 • 250 citations

Induction of the fibrinogen receptor on human platelets by intracellular mediators.

1987 • 240 citations

Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.

1994 • 239 citations

Platelet actuation

1995 • 238 citations

The Platelet Cytoskeleton

1993 • 235 citations

On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton.

1993 • 235 citations

Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet activation and comparisons with the adenylate cyclase inhibitory protein, Gi.

1986 • 235 citations

Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors.

1994 • 233 citations

Tyrosine Phosphorylation of the Fc Receptor γ-Chain in Collagen-stimulated Platelets

1996 • 233 citations

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase

1991 • 231 citations

Selective Inhibition of Aβ Fibril Formation

1996 • 229 citations

Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3.

1994 • 227 citations

Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.

1990 • 225 citations

Evidence for a role of myosin phosphorylation in the initiation of the platelet shape change response.

1984 • 223 citations

Haemostasis and Thrombosis

1988 • 221 citations

Adhesive signaling in platelets

1994 • 219 citations

Formation of lysophosphatidylcholine by human platelets in response to thrombin. Support for the phospholipase A2 pathway for the liberation of arachidonic acid.

1981 • 217 citations

Activation of Receptor-operated Cation Channels via P2X1 Not P2T Purinoceptors in Human Platelets

1996 • 213 citations

Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho.

1993 • 211 citations

Solution structure of a pleckstrin-homology domain

1994 • 211 citations

Emerging concepts in the Ras superfamily of GTP‐binding proteins

1993 • 208 citations

Novel α2-adrenoreceptors primarily responsible for inducing human platelet aggregation

1979 • 208 citations

Lipid modifications of G proteins

1994 • 206 citations

Redistribution of alpha-granules and their contents in thrombin-stimulated platelets.

1984 • 205 citations

Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S.

1990 • 204 citations

Signal transduction and the actin cytoskeleton: the roles of MARCKS and profilin

1992 • 203 citations

Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet-derived 12-hydroperoxy-icosatetraenoic acid.

1982 • 196 citations

Immunological Detection of Activated Platelets in Clinical Disorders

1991 • 194 citations

Biochemistry of Platelets

1986 • 194 citations

Interaction of pp60c-src, phospholipase C, inositol-lipid, and diacyglycerol kinases with the cytoskeletons of thrombin-stimulated platelets

1991 • 193 citations

Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK

1993 • 192 citations

Thrombin-induced exposure and prostacyclin inhibition of the receptor for factor VIII/von Willebrand factor on human platelets.

1982 • 190 citations

The Origin and Nature of the Blood Plates

1906 • 189 citations

Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences.

1988 • 187 citations

The histogenesis of the blood platelets

1910 • 186 citations

Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase

1986 • 183 citations

Thrombin and Phorbol Esters Cause the Selective Phosphorylation of a G Protein Other Than Gi in Human Platelets

1989 • 181 citations

The ras superfamily of small GTP-binding proteins

1990 • 180 citations

Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase. Thromboregulation by endothelial cells.

1991 • 180 citations

G protein beta gamma subunits. Simplified purification and properties of novel isoforms.

1994 • 178 citations

Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4 synthesis in human polymorphonuclear leukocytes.

1982 • 177 citations

Gβγ interactions with PH domains and Ras-MAPK signaling pathways

1995 • 177 citations

Ultrastructure of clots during isometric contraction.

1982 • 176 citations

G alpha 13 stimulates Na-H exchange.

1994 • 175 citations

The intracellular retention of newly synthesized platelet-activating factor.

1986 • 175 citations

Isolation and characterization of actin and actin-binding protein from human platelets.

1981 • 174 citations

Linkage of a membrane skeleton to integral membrane glycoproteins in human platelets. Identification of one of the glycoproteins as glycoprotein Ib.

1985 • 173 citations

Signaling through G Proteins in Platelets: to the Integrins and Beyond

1997 • 172 citations

Cytosolic Phospholipase A2 Is Phosphorylated in Collagen- and Thrombin-stimulated Human Platelets Independent of Protein Kinase C and Mitogen-activated Protein Kinase

1995 • 172 citations

Aggregating human platelets cause direct contraction and endothelium-dependent relaxation of isolated canine coronary arteries. Role of serotonin, thromboxane A2, and adenine nucleotides.

1986 • 169 citations

Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes

1991 • 168 citations

Regulation of protein tyrosine kinases in platelets

1994 • 168 citations

Phosphoinositide 3-kinase: A new effector in signal transduction?

1991 • 166 citations

Kinetics of the thrombin-induced release of calcium(II) by platelets

1973 • 164 citations

The α2β1 Integrin Is a Necessary Co-receptor for Collagen-induced Activation of Syk and the Subsequent Phosphorylation of Phospholipase Cγ2 in Platelets

1996 • 160 citations

Interaction between G-protein beta and gamma subunit types is selective.

1992 • 157 citations

Shear Rate Dependent Inhibition of Platelet Adhesion and Aggregation on Collagenous Surfaces by Antibodies to Human Factor VIII/von Willebrand Factor

1980 • 156 citations

Deficiency of the Complement Regulatory Protein, Decay-Accelerating Factor, on Membranes of Granulocytes, Monocytes, and Platelets in Paroxysmal Nocturnal Hemoglobinuria

1985 • 153 citations

Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

1996 • 152 citations

Factor VIII/von Willebrand factor in subendothelium mediates platelet adhesion

1985 • 152 citations

Changes in Cytoplasmic pH and in Membrane Potential in Thrombin-Stimulated Human Platelets

1981 • 152 citations

Phosphoinositide Phospholipases and G Proteins in Hormone Action

1994 • 151 citations

Effects of collagen, ionophore A23187 and prostaglandin E1 on the phosphorylation of specific proteins in blood platelets

1979 • 150 citations

Isolation of cDNA Clones Encoding Eight Different Human G Protein γ Subunits, Including Three Novel Forms Designated the γ4, γ10, and γ11 Subunits

1995 • 149 citations

Myosin phosphorylation in intact platelets.

1981 • 148 citations

A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol

1994 • 148 citations

Platelet-leukocyte interaction: selective binding of thrombin- stimulated platelets to human monocytes, polymorphonuclear leukocytes, and related cell lines

1986 • 148 citations

Cyclic nucleotides control a system which regulates Ca2+ sensitivity of platelet secretion

1984 • 147 citations

Functional comparison of villin and gelsolin. Effects of Ca2+, KCl, and polyphosphoinositides.

1988 • 145 citations

Differential activation of platelet phospholipases by thrombin and ionophore A23187.

1981 • 145 citations

A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation.

1992 • 144 citations

Prostacyclin and Sodium Nitroprusside Inhibit the Activity of the Platelet Inositol 1,4,5-Trisphosphate Receptor and Promote Its Phosphorylation

1996 • 143 citations

Surface membrane expression by human blood leukocytes and platelets of decay-accelerating factor, a regulatory protein of the complement system

1985 • 143 citations

Serotonin secretion from human platelets may be modified by Ca2+-activated, phospholipid-dependent myosin phosphorylation.

1984 • 143 citations

Platelet-derived microparticle formation involves glycoprotein IIb-IIIa. Inhibition by RGDS and a Glanzmann's thrombasthenia defect

1993 • 142 citations

A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets.

1989 • 141 citations

Collagen stimulates tyrosine phosphorylation of phospholipase C‐γ2 but not phospholipase C‐γ1 in human platelets

1994 • 141 citations

The response to thromboxane A2 analogues in human platelets. Discrimination of two binding sites linked to distinct effector systems.

1990 • 141 citations

12S,20-dihydroxyicosatetraenoic acid: a new icosanoid synthesized by neutrophils from 12S-hydroxyicosatetraenoic acid produced by thrombin- or collagen-stimulated platelets.

1984 • 139 citations

Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombin.

1991 • 137 citations

Inhibitory action of cyclic GMP on secretion, polyphosphoinositide hydrolysis and calcium mobilization in thrombin-stimulated human platelets

1986 • 136 citations

Phosphoinositide 3-Kinase γ and p85/Phosphoinositide 3-Kinase in Platelets

1996 • 135 citations

Platelet responses and metabolism

1986 • 133 citations

Vasodilator‐stimulated protein phosphorylation in platelets is mediated by cAMP‐ and cGMP‐dependent protein kinases

1987 • 132 citations

Identification and Molecular Cloning of a p21cdc42/rac1-activated Serine/Threonine Kinase That Is Rapidly Activated by Thrombin in Platelets

1995 • 132 citations

Evidence that the phosphatidylinositol cycle is linked to cell motility

1988 • 131 citations

The selectivity of the thrombin-induced platelet release reaction: subcellular localization of released and retained constituents.

1970 • 130 citations

Translocation of protein kinase C isozymes in thrombin-stimulated human platelets. Correlation with 1,2-diacylglycerol levels.

1992 • 130 citations

Monoclonal Antibody to Human Platelet Glycoprotein I II. EFFECTS ON HUMAN PLATELET FUNCTION

1981 • 127 citations

Differential Activation of Cytosolic Phospholipase A2 (cPLA2) by Thrombin and Thrombin Receptor Agonist Peptide in Human Platelets. EVIDENCE FOR ACTIVATION OF cPLA2 INDEPENDENT OF THE MITOGEN-ACTIVATED PROTEIN KINASES ERK1/2

1995 • 126 citations

Binding kinetics of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to intact human platelets

1984 • 125 citations

The fatty acid composition of phosphatidylinositol from thrombin-stimulated human platelets.

1981 • 125 citations

Cytoplasmic Ca2+ in platelets is controlled by cyclic AMP: Antagonism between stimulators and inhibitors of adenylate cyclase

1984 • 124 citations

Response of platelets to tissue injury

1968 • 123 citations

Unidirectional transfer of prostaglandin endoperoxides between platelets and endothelial cells.

1984 • 122 citations

G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.

1995 • 122 citations

Characteristics of the binding of platelet-activating factor to platelets of different animal species

1984 • 122 citations

Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide)

1992 • 121 citations

p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets.

1992 • 119 citations

Platelet Receptors for Collagen

1997 • 119 citations

Evidence for distinct prostaglandin I2 and D2 receptors in human platelets.

1979 • 118 citations

Effect of Fibrinogen on the Aggregation of Platelets by Adenosine Diphosphate

1964 • 118 citations

Phosphatidylinositol 3-Kinase Mediates the Inhibitory Effect of Epidermal Growth Factor on Calcium-dependent Chloride Secretion

1996 • 118 citations

Effects of antimycin and 2-deoxyglucose on adenine nucleotides in human platelets. Role of metabolic adenosine triphosphate in primary aggregation, secondary aggregation and shape change of platelets

1974 • 118 citations

Fibrinogen and Adenosine Diphosphate-induced Aggregation of Platelets

1964 • 117 citations

Signaling through G Proteins and G Protein-coupled Receptors during Platelet Activation

1993 • 116 citations

The ras superfamily of GTP‐binding proteins: guidelines on nomenclature

1992 • 116 citations

Platelet dense granule membranes contain both granulophysin and P- selectin (GMP-140)

1992 • 114 citations

Actin filament content and organization in unstimulated platelets.

1984 • 112 citations

Binding of Vav to Grb2 through dimerization of Src homology 3 domains.

1994 • 112 citations

Factor VIII/von Willebrand factor in subendothelium mediates platelet adhesion

1985 • 112 citations

Diacylglycerol Production, Ca²⁺Influx, and ProteinKinase C Activation in Sustained Cellular Responses*

1995 • 111 citations

Ligand binding to thromboxane receptors on human platelets: correlation with biological activity

1983 • 111 citations

Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins.

1993 • 110 citations

p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation

1994 • 107 citations

Complement C5b-9-stimulated platelet secretion is associated with a Ca2+-initiated activation of cellular protein kinases.

1987 • 105 citations

Characterization of the Platelet Prostaglandin D2 Receptor

1979 • 103 citations

Cyclic AMP-dependent phosphorylation of the inositol-1,4,5-trisphosphate receptor inhibits Ca2+ release from platelet membranes

1992 • 102 citations

Repolarization of the membrane potential of blood platelets after complement damage: evidence for a Ca++ -dependent exocytotic elimination of C5b-9 pores

1986 • 102 citations

Ra Adenosine receptors in human platelets

1984 • 102 citations

Demonstration of cGMP‐dependent protein kinase and cGMP‐dependent phosphorylation in cell‐free extracts of platelets

1986 • 102 citations

Platelets: Cellular Response Mechanisms and their Biological Significance

1981 • 102 citations

Platelet actin: Sub‐cellular distribution and association with profilin

1978 • 101 citations

Regulatory control of complement on blood platelets

1989 • 101 citations

Small Molecular Weight GTP-binding Proteins in Human Platelet Membranes

1989 • 100 citations

Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3-Kinase

1995 • 100 citations

Identification of the ral and rac1 Gene Products, Low Molecular Mass GTP-binding Proteins from Human Platelets

1989 • 100 citations

Identification of Novel Pleckstrin Homology (PH) Domains Provides a Hypothesis for PH Domain Function

1993 • 99 citations

rap1B, a cAMP-dependent protein kinase substrate, associates with the platelet cytoskeleton.

1990 • 99 citations

Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.

1994 • 98 citations

Calcium Signalling in Platelets and Other Cells

1994 • 98 citations

The Platelet Dense Tubular System: its Relationship to Prostaglandin Synthesis and Calcium Flux

1978 • 97 citations

Structure and function of the glycoprotein Ib-IX-V complex

1997 • 95 citations

Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein.

1990 • 95 citations

Effects of gelsolin on human platelet cytosolic phosphoinositide-phospholipase C isozymes.

1992 • 94 citations

Sequestration of a G-protein βγ Subunit or ADP-ribosylation of Rho Can Inhibit Thrombin-induced Activation of Platelet Phosphoinositide 3-Kinases

1995 • 93 citations

Inositol lipids, phosphatidate and diacylglycerol share stearoylarachidonoylglycerol as a common backbone in thrombin-stimulated human platelets

1984 • 93 citations

Coagulation Factor IXa Binding to Activated Platelets and Platelet-Derived Microparticles: A Flow Cytometric Study

1992 • 92 citations

Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets

1991 • 92 citations

Activation of platelets by alpha-thrombin is a receptor-mediated event. D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone-thrombin, but not N alpha-tosyl-L-lysine chloromethyl ketone-thrombin, binds to the high affinity thrombin receptor.

1986 • 92 citations

On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activity.

1986 • 90 citations

Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets.

1988 • 90 citations

Effect of complement proteins C5b-9 on blood platelets. Evidence for reversible depolarization of membrane potential.

1985 • 90 citations

Effect of Cellular Expression of Pleckstrin Homology Domains on Gi-coupled Receptor Signaling

1995 • 87 citations

Platelet-derived growth factors

1989 • 85 citations

The role of protein phosphorylation and cytoskeletal reorganization in microparticle formation from the platelet plasma membrane

1994 • 85 citations

Inhibition of PGE1-stimulated cAMP accumulation in human platelets by thromboxane A2

1977 • 84 citations

Interaction of platelet factor 4 with human platelets

1985 • 84 citations

Contributions of the I and EF Hand Domains to the Divalent Cation-dependent Collagen Binding Activity of the α2β1 Integrin

1997 • 84 citations

Platelets; a practical approach

1998 • 82 citations

Lipoxin generation by permeabilized human platelets

1992 • 82 citations

Interrelationships among platelet responses: studies on the burst in proton liberation, lactate production, and oxygen uptake during platelet aggregation and Ca2+ secretion

1981 • 82 citations

Differential energy requirements for platelet responses. A simultaneous study of aggregation, three secretory processes, arachidonate liberation, phosphatidylinositol breakdown and phosphatidate production

1982 • 81 citations

The Platelet-Stimulating Effect of Adrenaline Through α2-Adrenergic Receptors Requires Simultaneous Activation by a True Stimulatory Platelet Agonist

1993 • 79 citations

Protein Modification: Palmitoylation in G-protein signaling pathways

1995 • 78 citations

Tyrosine Phosphorylation of the Novel Protein-tyrosine Kinase RAFTK during an Early Phase of Platelet Activation by an Integrin Glycoprotein IIb-IIIa-independent Mechanism

1997 • 78 citations

Pleckstrin homology (PH) domains in signal transducton

1994 • 77 citations

Repolarization of the membrane potential of blood platelets after complement damage: evidence for a Ca++ -dependent exocytotic elimination of C5b-9 pores

1986 • 77 citations

Further studies of the secretory pathway in thrombin-stimulated human platelets

1987 • 77 citations

Identification and functional characterization of protein kinase C isozymes in platelets and HEL cells.

1992 • 76 citations

Platelet-neutrophil interactions. (12S)-hydroxyeicosatetraen-1,20-dioic acid: a new eicosanoid synthesized by unstimulated neutrophils from (12S)-20-dihydroxyeicosatetraenoic acid.

1988 • 76 citations

Effect of cyclic amp on cytoplasmic free calcium in human platelets stimulated by thrombin: Direct measurement with quiǹ2

1983 • 75 citations

Distinct guanine nucleotide binding and release properties of the three Gi proteins.

1990 • 75 citations

Phosphorylation by cyclic adenosine 3':5'-monophosphate-dependent protein kinase regulates myosin light chain kinase.

1980 • 74 citations

Contractile properties of actomyosin from human blood platelets

1978 • 74 citations

Thrombin Receptor Activation and Integrin Engagement Stimulate Tyrosine Phosphorylation of the Proto-oncogene Product, p95vav, in Platelets

1996 • 74 citations

Platelet C1- inhibitor. A secreted alpha-granule protein.

1985 • 74 citations

Identification of a novel 33-kDa C1q-binding site on human blood platelets.

1994 • 73 citations

Specific binding of the thromboxane A2 antagonist 13-azaprostanoic acid to human platelet membranes

1983 • 73 citations

Functional relationship between cyclic AMP-dependent protein phosphorylation and platelet inhibition

1990 • 72 citations

Ionomycin can elevate intraplatelet Ca2+ and activate phospholipase a without activating phospholipase C

1984 • 72 citations

Interrelationships among platelet responses: studies on the burst in proton liberation, lactate production, and oxygen uptake during platelet aggregation and Ca2+ secretion

1981 • 72 citations

RAP2B: a RAS-related GTP-binding protein from platelets.

1990 • 71 citations

Identification of a putative thromboxane A2/prostaglandin H2 receptor in human platelet membranes.

1986 • 71 citations

Phosphorylated HSP27 associates with the activation-dependent cytoskeleton in human platelets

1994 • 71 citations

Expression of p60fyn in human platelets.

1990 • 70 citations

Evidence that changes in platelet cyclic AMP levels regulate the fibrinogen receptor on human platelets.

1982 • 70 citations

Agents that elevate cAMP levels in platelets decrease thrombin binding.

1987 • 69 citations

The 5-hydroxytryptamine system of blood platelets: physiology and pathophysiology

1987 • 69 citations

Role of rap1B and p21ras GTPase-activating protein in the regulation of phospholipase C-gamma 1 in human platelets.

1992 • 68 citations

Regulation of the activity of platelet-bound C3 convertase of the alternative pathway of complement by platelet factor H.

1987 • 67 citations

Hemostasis and Thrombosis

2004 • 67 citations

Factor XIII

1979 • 66 citations

Changes in the Adenylate Energy Charge in Human Blood Platelets induced by Adenosine Diphosphate

1973 • 65 citations

A search for the platelet secretory pathway using electron dense tracers.

1970 • 64 citations

Endogenous Cleavage of Phospholipase C-β3 by Agonist-induced Activation of Calpain in Human Platelets

1995 • 64 citations

Platelets: A practical approach

1997 • 64 citations

Platelet-Neutrophil Interactions

1991 • 63 citations

THE CONTROL OF PLATELET RESPONSIVENESS BY AGENTS THAT INFLUENCE CYCLIC AMP METABOLISM

1972 • 63 citations

Dynamics of membrane-cytoskeleton interactions in activated blood platelets

1982 • 63 citations

Decreased platelet adhesion on vessel segments in von Willebrand's disease: a defect in initial platelet attachment.

1983 • 63 citations

Platelet Microparticles: A Carrier of Platelet-Activating Factor?

1996 • 63 citations

15-Lipoxygenase in human platelets.

1985 • 63 citations

A rho gene product in human blood platelets. I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein.

1992 • 62 citations

Human Fc gamma receptors: stable inter-donor variation in quantitative expression on platelets correlates with functional responses.

1987 • 62 citations

Platelet factor 3 in plasma fractions: Its relation to microparticle size and thromboses

1995 • 62 citations

Identification of a platelet dense granule membrane protein that is deficient in a patient with the Hermansky-Pudlak syndrome

1991 • 61 citations

p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation.

1994 • 61 citations

Activation of Na+/H+ exchange in human platelets stimulated by thrombin and a phorbol ester

1987 • 61 citations

Effects of Nitrovasodilators on Platelet Cyclic Nucleotide Levels in Rabbit Blood; Role for Cyclic AMP in Synergistic Inhibition of Platelet Function by SIN-1 and Prostaglandin E1

1991 • 61 citations

Platelets and Microtubules

1980 • 60 citations

Electron microscopic studies of platelet secretion.

1974 • 58 citations

Inhibition by cyclic AMP of guanine nucleotide‐induced activation of phosphoinositide‐specific phospholipase C in human platelets

1989 • 58 citations

Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes

1991 • 57 citations

Induction of prostanoid synthesis in human platelets by the late complement components C5b-9 and channel forming antibiotic nystatin: inhibition of the reacylation of liberated arachidonic acid.

1985 • 56 citations

7 A review of the role of platelet membrane glycoproteins in the platelet-vessel wall interaction

1993 • 56 citations

Structure and Function of rap Proteins in Human Platelets

1994 • 56 citations

Evidence that cyclic AMP may regulate Ca2+-mobilization and phospholipases in thrombin-stimulated human platelets

1983 • 55 citations

Isolation of a subpopulation of glycoprotein IIb-III from platelet membranes that is bound to membrane actin.

1985 • 55 citations

Cellular distribution of complement receptor type 4 (CR4): expression on human platelets.

1987 • 54 citations

Cyclic AMP stimulates Ca2+-ATPase-mediated Ca2+ extrusion from human platelets

1992 • 54 citations

Protein Kinase C Regulates Pleckstrin by Phosphorylation of Sites Adjacent to the N-terminal Pleckstrin Homology Domain

1995 • 54 citations

Properties of protein kinase c subspecies in human platelets

1988 • 54 citations

A New Protein Kinase C, nPKCη′, and nPCKθ Are Expressed in Human Platelets: Involvement of nPKCη′ and nPKCθ in Signal Transduction Stimulated by PAF

1993 • 53 citations

Effects of thrombin, phorbol myristate acetate and prostaglandin D₂ on 40–41 kDa protein that is ADP ribosylated by pertussis toxin in platelets

1986 • 52 citations

Specific binding sites for prostaglandin D2 on human platelets

1979 • 52 citations

Complement proteins C5b-9 initiate secretion of platelet storage granules without increased binding of fibrinogen or von Willebrand factor to newly expressed cell surface GPIIb-IIIa.

1988 • 51 citations

Protein-tyrosine phosphorylation and aggregation of intact human platelets by vanadate with H2O2

1990 • 51 citations

Platelet Activation: New Aspects

1996 • 51 citations

Subcellular Organization of Receptor-Mediated Phosphoinositide Turnover*

1992 • 50 citations

Human blood platelets possess specific binding sites for C1q.

1987 • 50 citations

Thrombopoietin and Thrombin Induce Tyrosine Phosphorylation of Vav in Human Blood Platelets

1997 • 49 citations

Thrombin stimulates Na⁺‐H⁺ exchange across the human platelet plasma membrane

1984 • 48 citations

Quantification of energy consumption in platelets during thrombin-induced aggregation and secretion. Tight coupling between platelet responses and the increment in energy consumption

1984 • 47 citations

The phosphoinositides exist in multiple metabolic pools in rabbit platelets

1986 • 47 citations

Human megakaryocytes express clusterin and package it without apolipoprotein A-1 into alpha-granules

1993 • 46 citations

Current aspects on human platelet activation and responses

1987 • 46 citations

Effects of papaverine derivatives on cyclic AMP phosphodiesterase of human platelets

1970 • 46 citations

Polyphosphoinositide synthesis in platelets stimulated with low concentrations of thrombin is enhanced before the activation of phospholipase C

1990 • 46 citations

Pleckstrin Inhibits Phosphoinositide Hydrolysis Initiated by G-protein-coupled and Growth Factor Receptors. A ROLE FOR PLECKSTRIN'S PH DOMAINS

1995 • 45 citations

Phosphopleckstrin Inhibits Gβγ-activable Platelet Phosphatidylinositol-4,5-bisphosphate 3-Kinase

1996 • 44 citations

Distribution and relative levels of expression of the phosphoinositidase-C-linked G-proteins Gqα and G11α: Absence of G11α in human platelets and haemopoietically derived cell lines

1993 • 44 citations

Paroxysmal nocturnal hemoglobinuria. Enhanced stimulation of platelets by the terminal complement components is related to the lack of C8bp in the membrane.

1988 • 44 citations

Treatment of human platelets with trypsin, thrombin, or collagen inhibits the pertussis toxin-induced ADP-ribosylation of a 41-kDa protein.

1986 • 43 citations

Vasopressin inhibits the adenylate cyclase activity of human platelet particulate fraction through V₁‐receptors

1983 • 42 citations

Interralation of prostaglandin endoperoxide (prostaglandin G2) and cyclic 3′,5′-adenosine monophosphate in human blood platelets

1977 • 41 citations

Metabolism of Phosphoinositides

1970 • 41 citations

Agents that elevate platelet cAMP stimulate the formation of phosphatidylinositol 4‐phosphate in intact human platelets

1986 • 41 citations

Stimulation of dense tubular Ca2+ uptake in human platelets by cAMP

1992 • 40 citations

Turnover of the phosphomonoester groups of polyphospoinositol lipids in unstimulated human platelets

1987 • 40 citations

Physiopathological Significance of Catalytic Phospholipids in the Generation of Thrombin

1996 • 39 citations

Desensitization and antagonism of vasopressin-induced phosphoinositide metabolism and elevation of cytosolic free calcium concentration in human platelets

1986 • 39 citations

Phosphorylation of Platelet Pleckstrin Activates Inositol Polyphosphate 5-Phosphatase I

1997 • 39 citations

Regulation of complement functional efficiency by histidine-rich glycoprotein

1992 • 39 citations

Interactions Between Nitric Oxide and Prostacyclin

1993 • 39 citations

Signaling Inositol Polyphosphate-5-phosphatase

1997 • 38 citations

Activation of human platelets through gp140, the C3d/EBV receptor (CR2)

1987 • 38 citations

Incorporation of synthetic 1,2‐diacylglycerol into platelet phosphatidylinositol is increased by cyclic AMP

1986 • 37 citations

Simultaneous measurement of aggregation, secretion, oxygen uptake, proton production, and intracellular metabolites in the same platelet suspension

1979 • 36 citations

Synergistic phosphorylation of the focal adhesion-associated vasodilator-stimulated phosphoprotein in intact human platelets in response to cGMP- and cAMP-elevating platelet inhibitors

1994 • 35 citations

G protein pathways: signal processing by effectors

1994 • 34 citations

Purification and characterization of a cytosolic phosphoinositide-phospholipase C (γ2-type) from human platelets

1990 • 34 citations

Translocation of an SH2‐containing protein tyrosine phosphatase (SH‐PTP1) to the cytoskeleton of thrombin‐activated platelets

1994 • 33 citations

Views of the Platelet Cytoskeleton at Rest and at Work^a

1987 • 33 citations

The antagonism of prostaglandins I2, E1 and D2 by prostaglandin E2 in human platelets

1981 • 33 citations

The role of membrane lipid in the platelet storage lesion.

1992 • 32 citations

Identification of multiple ral gene products in human platelets that account for some but not all of the platelet G_n‐proteins

1990 • 32 citations

Purification and characterization of a phosphatidylinositol transfer protein from human platelets

1985 • 32 citations

Solubilization of a thromboxane A2/prostaglandin H2 antagonist binding site from human platelets.

1985 • 31 citations

Identification of a 33-Kd protein associated with the alpha-granule membrane (GMP-33) that is expressed on the surface of activated platelets

1992 • 31 citations

CHARACTERIZATION OF HUMAN PLATELET VASOPRESSIN RECEPTOR AND THE RELATION BETWEEN VASOPRESSIN‐INDUCED PLATELET AGGREGATION AND VASOPRESSIN BINDING TO PLATELETS

1988 • 30 citations

Identification of α-Subunits of Trimeric GTP-Binding Proteins in Human Platelets by RT-PCR

1995 • 30 citations

TYROSINE KINASES IN PLATELET SIGNALLING

1993 • 29 citations

Inositol 1,4,5-Trisphosphate-Mediated Ca²⁺Release from Platelet Internal Membranes Is Regulated by Differential Phosphorylation

1996 • 29 citations

Association of alternative complement pathway components with human blood platelets: Secretion and localization of factor D and β1H globulin

1981 • 28 citations

Peptides and monoclonal antibodies which bind to platelet glycoproteins IIb and/or IIIa inhibit clot retraction

1988 • 28 citations

Association of phosphatidylinositol kinase and phosphatidylinositol 4‐phosphate kinase activities with the cytoskeleton in human platelets

1989 • 28 citations

Subcellular localization of inositol lipids in blood platelets as deduced from the use of labelled precursors

1987 • 27 citations

Kinetics of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced fibrinogen binding to human platelets.

1986 • 27 citations

Rates of production and consumption of phosphatidic acid upon thrombin stimulation of human platelets

1988 • 26 citations

Prostaglandin E1 and forskolin antagonize C-kinase activation in the human platelet

1987 • 26 citations

Classification and possible mechanisms of action of some drugs that inhibit platelet aggregation.

1975 • 26 citations

Binding Properties and Inhibition of Platelet Aggregation by a Monoclonal Antibody to CD31 (PECAM-1)

1997 • 25 citations

Demonstration of platelet fibrinogen secretion via the surface connecting system

1974 • 25 citations

Inhibition of adenosine 3′,5′-cyclic monophosphate phosphodiesterase

1970 • 24 citations

Demonstration of platelet fibrinogen secretion via the surface connecting system

1973 • 24 citations

Mechanisms for Expression of Thrombospondin on the Platelet Cell Surface

1987 • 24 citations

Regulation of platelet function by sodium-hydrogen exchange

1995 • 23 citations

Chlorpromazine increases the turnover of metabolically active phosphoinositides and elevates the steady-state level of phosphatidylinositol-4-phosphate in human platelets

1992 • 23 citations

Rapid effects ofphorbol ester on platelet shape change, cytoskeleton and calcium transient

1986 • 22 citations

Secretion of the terminal complement proteins, C5–C9, by human platelets

1989 • 22 citations

Evidence that chlorpromazine and prostaglandin E₁ but not neomycin interfere with the inositol phospholipid metabolism in intact human platelets

1990 • 21 citations

Epinephrine suppresses rap1B.GAP-activated GTPase activity in human platelets.

1992 • 21 citations

Diacylglycerol Elevations in Control Platelets are Unaccompanied by Pleckstrin Phosphorylation. Implications for the Role of Diacylglycerol in Platelet Activation

1995 • 20 citations

The Homologous Species Restriction of the Complement Attack: Structure and Function of the C8 Binding Protein

1988 • 20 citations

Platelet glycoprotein IIb–IIIa is associated with 21-kDa GTP-binding protein

1991 • 19 citations

Platelet cytoskeletal components involved in shape change and secretion

1986 • 19 citations

Partial purification and characterization of phosphatidylinositol kinases from human platelets

1990 • 19 citations

Diacylglycerol Elevations in Control Platelets are Unaccompanied by Pleckstrin Phosphorylation. Implications for the Role of Diacylglycerol in Platelet Activation

1995 • 18 citations

Identification and partial characterization of human platelet C1q binding sites.

1988 • 18 citations

α_2A‐Adrenergic receptors activate protein kinase C in human platelets via a pertussis toxin‐sensitive G‐protein

1994 • 17 citations

The Platelet-Amine Storage Granule

1992 • 17 citations

Phosphoinositide metabolism in resting and thrombin‐stimulated human platelets Evidence against metabolic heterogeneity

1987 • 17 citations

Thrombin per se Does Not Induce Tyrosine Protein Phosphorylation in Human Platelets as Judged by Western Blotting, While Collagen Does: The Significance of Synergistic, Autocrine Stimulation

1998 • 16 citations

Polyphosphoinositide synthesis and platelet shape change

1997 • 15 citations

Phosphorylation of phosphoinositides in human platelets

1986 • 15 citations

Purification and characterization of the human type 1 Ins(1,4,5)P3 receptor from platelets and comparison with receptor subtypes in other normal and transformed blood cells

1995 • 15 citations

Characterization of the protein kinase activities of human platelet supernatant and particulate fractions

1984 • 14 citations

Nitric Oxide (NO)-Platelet Interactions: Inhibition is Independent of the Prostanoid and ADP Pathways

1995 • 14 citations

A Model for Assembly of Coagulation Factor Complexes on Cell Surfaces: Prothrombin Activation on Platelets

1986 • 13 citations

Blood platelet shape change ABCs

1987 • 13 citations

Nitric oxide as a vascular modulator

1995 • 12 citations

Study of the reactions of blood with artificial surfaces. Use of the thrombogenerator.

1974 • 12 citations

Evidence for tight metabolic control of the receptor-activated polyphosphoinositide cycle in human platelets

1989 • 11 citations

Stochastic response of human blood platelets to stimulation of shape changes and secretion.

1986 • 10 citations

Recent Aspects of TXA₂Action on Platelets and Blood Vessels

1991 • 10 citations

Partial purification and characterization of two forms of phosphatidylinositol 4-phosphate 5-kinase from human platelet membrane

1991 • 9 citations

Regulatory and catalytic domains of platelet cAMP phosphodiesterases: targets for drug design.

1995 • 9 citations

Characterization of phospholipase A2 secretion from human platelets

1993 • 9 citations

Inhibition of Phosphatidylinositol 4-phosphate 5-kinase by Cyclic AMP in Human Platelets

1994 • 8 citations

Platelet Regulation of Thombus Formation

1986 • 5 citations

Properties of protein kinase C subspecies in human platelets

1990 • 5 citations

Platelet Microtubule Subunit Proteins

1979 • 4 citations

Stimulation of the 23-Kd protein cAMP dependent phosphorylation by inositol 1,4,5 trisphosphate in human platelet membrane vesicles

1987 • 4 citations

Platelet microtubule subunit proteins.

1980 • 4 citations

Determination of the Kinetics of Na⁺/H⁺ Exchange in Platelets Using the Coulter S-Plus Cell Counter

1994 • 3 citations

Discussion

1925 • 1 citations