Lipid modifications of G proteins: alpha subunits are palmitoylated.

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Homologies Between Signal Transducing G Proteins and ras Gene Products

1984 • 500 citations

Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43.

1989 • 383 citations

Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.

1991 • 320 citations

G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma

1992 • 302 citations

G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.

1990 • 277 citations

Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins.

1987 • 276 citations

Expression of Gsα in Escherichia coli

1989 • 262 citations

Lipid modification at the N terminus of photoreceptor G-protein α-subunit

1992 • 228 citations

Splice Variants of the α Subunit of the G Protein G _s Activate Both Adenylyl Cyclase and Calcium Channels

1989 • 225 citations

Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog

1985 • 223 citations

The rod transducin alpha subunit amino terminus is heterogeneously fatty acylated.

1992 • 213 citations

Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.

1992 • 205 citations

Fatty acylated proteins as components of intracellular signaling pathways

1990 • 202 citations

Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain.

1992 • 182 citations

A membrane-targeting signal in the amino terminus of the neuronal protein GAP-43

1989 • 176 citations

The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits.

1992 • 148 citations

[19] Synthetic peptide antisera with determined specificity for G protein α or β subunits

1991 • 114 citations

Myristyl and palmityl acylation of the insulin receptor.

1987 • 114 citations

The G protein connection: molecular basis of membrane association

1991 • 114 citations

Expression and purification of functional G protein alpha subunits using a baculovirus expression system.

1992 • 85 citations

Subunit dissociation is the mechanism for hormonal activation of the Gs protein in native membranes.

1988 • 74 citations

Isolation of the alpha subunits of GTP-binding regulatory proteins by affinity chromatography with immobilized beta gamma subunits.

1989 • 65 citations

Translocation of alpha subunits of stimulatory guanine nucleotide-binding proteins through stimulation of the prostacyclin receptor in mouse mastocytoma cells.

1992 • 44 citations

The carboxy-terminal domain of Gs alpha is necessary for anchorage of the activated form in the plasma membrane.

1990 • 27 citations

Amino- and carboxy-terminal deletion mutants of Gs alpha are localized to the particulate fraction of transfected COS cells.

1992 • 20 citations

Amino acids 367-376 of the Gs alpha subunit induce membrane association when fused to soluble amino-terminal deleted Gi1 alpha subunit.

1991 • 12 citations