Prostacyclin and Sodium Nitroprusside Inhibit the Activity of the Platelet Inositol 1,4,5-Trisphosphate Receptor and Promote Its Phosphorylation

Capacitative calcium entry revisited

1990 • 1,499 citations

Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400

1989 • 1,039 citations

Molecular mechanisms of platelet activation.

1989 • 903 citations

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx

1993 • 892 citations

Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium.

1988 • 359 citations

Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP.

1990 • 354 citations

Calcium Signaling in Human Platelets

1990 • 348 citations

The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin.

1984 • 319 citations

1,2‐Dioxetanes: Novel chemiluminescent enzyme substrates. Applications to immunoassays

1989 • 286 citations

A GTP-dependent step in the activation mechanism of capacitative calcium influx.

1993 • 283 citations

Co-expression in vertebrate tissues and cell lines of multiple inositol 1,4,5-trisphosphate (InsP3) receptors with distinct affinities for InsP3.

1994 • 279 citations

The kinetics of changes in intracellular calcium concentration in fura-2-loaded human platelets.

1987 • 245 citations

Inositol 1,4,5-trisphosphate receptors: distinct neuronal and nonneuronal forms derived by alternative splicing differ in phosphorylation.

1991 • 233 citations

Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase.

1994 • 222 citations

The cytoplasmic concentration of free calcium in platelets is controlled by stimulators of cyclic AMP production (PGD2, PGE1, forskolin)

1983 • 217 citations

A sarco/endoplasmic reticulum Ca(2+)-ATPase 3-type Ca2+ pump is expressed in platelets, in lymphoid cells, and in mast cells.

1994 • 209 citations

Inhibition of thapsigargin-induced calcium entry by microinjected guanine nucleotide analogues. Evidence for the involvement of a small G-protein in capacitative calcium entry.

1993 • 183 citations

Inositol 1,4,5-trisphosphate receptor

1993 • 178 citations

Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets.

1992 • 175 citations

The mechanism for synergism between phospholipase C- and adenylylcyclase-linked hormones in liver. Cyclic AMP-dependent kinase augments inositol trisphosphate-mediated Ca2+ mobilization without increasing the cellular levels of inositol polyphosphates.

1991 • 166 citations

Cyclic AMP-dependent phosphorylation of an immunoaffinity-purified homotetrameric inositol 1,4,5-trisphosphate receptor (type I) increases Ca2+ flux in reconstituted lipid vesicles.

1994 • 156 citations

ADP evokes biphasic Ca2+ influx in fura-2-loaded human platelets. Evidence for Ca2+ entry regulated by the intracellular Ca2+ store

1990 • 156 citations

Inhibitors of membrane transport system for organic anions block fura-2 excretion from PC12 and N2A cells

1988 • 153 citations

Thrombin and ionomycin can raise platelet cytosolic Ca2+ to micromolar levels by discharge of internal Ca2+ stores: Studies using fura-2

1986 • 149 citations

Inhibitory action of guanosine 3′,5′-monophosphate on thrombin-induced phosphatidylinositol turnover and protein phosphorylation in human platelets

1981 • 140 citations

Transmembrane topology and sites of N-glycosylation of inositol 1,4,5-trisphosphate receptor.

1994 • 136 citations

Inhibitory action of cyclic GMP on secretion, polyphosphoinositide hydrolysis and calcium mobilization in thrombin-stimulated human platelets

1986 • 136 citations

Degradation of a Calcium Influx Factor (CIF) Can Be Blocked by Phosphatase Inhibitors or Chelation of Ca2+

1995 • 134 citations

Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells

1993 • 130 citations

Cyclic AMP-dependent phosphorylation of the inositol-1,4,5-trisphosphate receptor inhibits Ca2+ release from platelet membranes

1992 • 102 citations

Agonist-induced Ca2+ influx into human platelets is secondary to the emptying of intracellular Ca2+ stores

1991 • 100 citations

Calcium influx evoked by Ca2+ store depletion in human platelets is more susceptible to cytochrome P-450 inhibitors than receptor-mediated calcium entry

1992 • 97 citations

Receptor-activated single channels in intact human platelets.

1990 • 96 citations

Multiple mechanisms by which protein kinase A potentiates inositol 1,4,5-trisphosphate-induced Ca2+ mobilization in permeabilized hepatocytes

1993 • 91 citations

Stimulated calcium efflux from fura‐2‐loaded human platelets.

1987 • 88 citations

Two classes of agonist-sensitive Ca2+ stores in platelets, as identified by their differential sensitivity to 2,5-di-(tert-butyl)-1,4-benzohydroquinone and thapsigargin

1995 • 85 citations

Different calcium pools in human platelets and their role in thromboxane A2 formation.

1991 • 81 citations

Regulation of calcium accumulation and efflux from platelet vesicles

1983 • 80 citations

Effect of cyclic amp on cytoplasmic free calcium in human platelets stimulated by thrombin: Direct measurement with quiǹ2

1983 • 75 citations

Cyclic AMP stimulates Ca2+-ATPase-mediated Ca2+ extrusion from human platelets

1992 • 54 citations

Inhibitory action of guanosine 3′,5′-monophosphate on thrombin-induced calcium mobilization in human platelets

1984 • 54 citations

Characterization of the inositol trisphosphate-sensitive and insensitive calcium stores by selective inhibition of the endoplasmic reticulum-type calcium pump isoforms in isolated platelet membrane vesicles

1993 • 51 citations

Possible role of a cAMP-dependent phosphorylation in the calcium release mediated by inositol 1,4,5-trisphosphate in human platelet membrane vesicles

1987 • 50 citations

The involvement of the cytoskeleton in regulating IP₃ receptor‐mediated internal Ca²⁺ release in human blood platelets.

1993 • 49 citations

Cyclic amp inhibits platelet activation independently of its effect on cytosolic free calcium

1985 • 48 citations

Prostacyclin inhibits platelet aggregation induced by phorbol ester or Ca2+ ionophore at steps distal to activation of protein kinase C and Ca2+-dependent protein kinases

1989 • 45 citations

Regulation of human platelet membrane Ca2+ transport by cAMP- and calmodulin-dependent phosphorylation

1987 • 45 citations

Forskolin and prostacyclin inhibit fluoride induced platelet activation and protein kinase C dependent responses

1988 • 40 citations

Cyclic nucleotides and intracellular‐calcium homeostasis in human platelets

1992 • 37 citations

Incorporation of synthetic 1,2‐diacylglycerol into platelet phosphatidylinositol is increased by cyclic AMP

1986 • 37 citations

Inhibitory action of cyclic AMP on inositol 1,4,5-trisphosphate-induced Ca2+ release in saponin-permeabilized platelets

1989 • 35 citations

Release of Ca2+ by inositol 1,4,5-trisphosphate in platelet membrane vesicles is not dependent on cyclic AMP-dependent protein kinase

1989 • 33 citations

Modulation of Ca2+ fluxes in isolated platelet vesicles: effects of cAMP-dependent protein kinase and protein kinase inhibitor on Ca2+ sequestration and release

1987 • 32 citations

Cyclic GMP and nitroprusside inhibit the activation of human platelets by fluoroaluminate

1989 • 30 citations

Ca2+ influx in platelets: activation by thrombin and by the depletion of the stores. Effect of cyclic nucleotides

1994 • 28 citations

Platelet activation by diacylglycerol or ionomycin is inhibited by nitroprusside

1991 • 21 citations

Ca²⁺ efflux from platelets

1994 • 15 citations

Agents that elevate the concentration of cAMP in platelets inhibit the formation of a NaDodSO4-resistant complex between thrombin and a 40-kDa protein.

1987 • 15 citations

Receptor occupancy regulates Ca2+ entry and intracellular Ca2+ redistribution in activated human platelets

1994 • 13 citations

Calcium sequestration in human platelets: Is it stimulated by protein kinase C?

1989 • 11 citations

Staurosporine-Independent Platelet Aggregation Induced by the Calcium Ionophore Ionomycin Is Inhibited by Prostacyclin and Sodium Nitroprusside and Stimulated by Adrenaline

1993 • 6 citations