The ras superfamily of small GTP-binding proteins

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

ras GENES

1987 • 3,818 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

1990 • 1,037 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

ras GTPase activating protein: Signal transmitter and signal terminator

1989 • 621 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway

1987 • 491 citations

Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis

1990 • 489 citations

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1989 • 478 citations

Prenyl proteins in eukaryotic cells: a new type of membrane anchor

1990 • 465 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

Binding of GAP to Activated PDGF Receptors

1990 • 396 citations

Cellular ras activity and phospholipid metabolism

1988 • 331 citations

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum.

1988 • 299 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

SRV2, a gene required for RAS activation of adenylate cyclase in yeast

1990 • 263 citations

Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the K rev -1 Gene Product

1990 • 254 citations

IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae.

1989 • 251 citations

Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein

1990 • 249 citations

ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels

1990 • 244 citations

A Cytosolic Protein Catalyzes the Release of GDP from p21 ^ras

1990 • 231 citations

Ras p21 as a Potential Mediator of Insulin Action in Xenopus Oocytes

1987 • 224 citations

Suppression of c-ras transformation by GTPase-activating protein

1990 • 166 citations

Identifying Tumor Suppressor Genes in Human Colorectal Cancer

1990 • 143 citations

Genetic analysis of mammalian GAP expressed in yeast

1989 • 141 citations

A novel membrane factor stimulates guanine nucleotide exchange reaction of ras proteins

1990 • 119 citations

Identification of Small Clusters of Divergent Amino Acids that Mediate the Opposing Effects of ras and K rev -1

1990 • 114 citations

Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s.

1990 • 105 citations

Diacylglycerol production in Xenopus laevis oocytes after microinjection of p21ras proteins is a consequence of activation of phosphatidylcholine metabolism.

1990 • 72 citations

The ras oncogene--an important regulatory element in lower eucaryotic organisms.

1989 • 64 citations

A guide to low molecular weight GTPases.

1990 • 15 citations