Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity.

The Nature and Significance of Platelet Products in Human Plasma

1967 • 1,471 citations

Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.

1985 • 968 citations

Detection of activated platelets in whole blood using activation- dependent monoclonal antibodies and flow cytometry

1987 • 736 citations

Changes in membrane phospholipid distribution during platelet activation

1983 • 551 citations

Fluorescence and bioluminescence measurement of cytoplasmic free calcium

1987 • 522 citations

Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery.

1986 • 457 citations

A monoclonal antibody to a membrane glycoprotein binds only to activated platelets.

1984 • 456 citations

A Spatial-Temporal Model of Cell Activation

1988 • 347 citations

Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.

1983 • 280 citations

Identification of two proteins (actin-binding protein and P235) that are hydrolyzed by endogenous Ca2+-dependent protease during platelet aggregation.

1985 • 236 citations

Platelet Membrane Glycoproteins

1985 • 184 citations

Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase

1986 • 183 citations

The interaction of bovine factor V and factor V-derived peptides with phospholipid vesicles.

1983 • 171 citations

Molecular organization of C9 within the membrane attack complex of complement. Induction of circular C9 polymerization by the C5b-8 assembly

1982 • 169 citations

The membrane attack complex

1984 • 145 citations

Expression of coagulant activity in human platelets: Release of membranous vesicles providing platelet factor 1 and platelet factor 3

1985 • 119 citations

Complement C5b-9-stimulated platelet secretion is associated with a Ca2+-initiated activation of cellular protein kinases.

1987 • 105 citations

Molecular reorganization of lipid bilayers by complement: a possible mechanism for membranolysis.

1979 • 95 citations

Prothrombinase complex assembly on the platelet surface is mediated through the 74,000-dalton component of factor Va.

1983 • 94 citations

Effect of complement proteins C5b-9 on blood platelets. Evidence for reversible depolarization of membrane potential.

1985 • 90 citations

On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activity.

1986 • 90 citations

Red-Cell and Platelet Fragmentation in Idiopathic Autoimmune Thrombocytopenic Purpura

1977 • 85 citations

Repolarization of the membrane potential of blood platelets after complement damage: evidence for a Ca++ -dependent exocytotic elimination of C5b-9 pores

1986 • 77 citations

Microthrombocytosis and Platelet Fragmentation Associated with Idiopathic/Autoimmune Thrombocytopenic Purpura

1975 • 74 citations

Association of factor V activity with membranous vesicles released from human platelets: Requirement for platelet stimulation

1985 • 69 citations

Platelet‐associated complement in chronic ITP

1985 • 62 citations

Complement proteins C5b-9 initiate secretion of platelet storage granules without increased binding of fibrinogen or von Willebrand factor to newly expressed cell surface GPIIb-IIIa.

1988 • 51 citations

A Two‐Stage Immunoradiometric Assay with ₁₂₅I‐Staphylococcal Protein A for the Detection of Antibodies and Complement on Human Blood Cells¹

1985 • 24 citations

Fluorescence resonance energy transfer study of the associative state of membrane-bound complexes of complement proteins C5b-8.

1985 • 19 citations

Loss of phospholipid asymmetry in dilauroylphosphatidylcholine induced plasma membrane vesicles from human platelets

1987 • 12 citations