Role of rap1B and p21ras GTPase-activating protein in the regulation of phospholipase C-gamma 1 in human platelets.

Oncogenes and signal transduction

1991 • 2,816 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G _q

1991 • 886 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.

1989 • 402 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

Biochemical mechanisms of platelet activation

1989 • 370 citations

Antiphosphotyrosine Recovery of Phospholipase C Activity After EGF Treatment of A-431 Cells

1988 • 324 citations

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

1990 • 314 citations

Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.

1991 • 279 citations

Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.

1989 • 276 citations

Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells.

1989 • 262 citations

CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.

1991 • 258 citations

Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the K rev -1 Gene Product

1990 • 254 citations

Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets.

1989 • 250 citations

Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins.

1990 • 237 citations

Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C.

1989 • 235 citations

Inositol phospholipid-specific phospholipase C: interaction of the γ isoform with tyrosine kinase

1991 • 233 citations

Platelet tyrosine-specific protein phosphorylation is regulated by thrombin.

1988 • 229 citations

Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells

1991 • 168 citations

A Second Type of Rat Phosphoinositide-specific Phospholipase C Containing a src-related Sequence Not Essential for Phosphoinositide-hydrolyzing Activity

1989 • 160 citations

Specific binding of [alpha-32P]GTP to cytosolic and membrane-bound proteins of human platelets correlates with the activation of phospholipase C.

1987 • 157 citations

Stimulation of Phospholipase C-γ1 Membrane Association by Epidermal Growth Factor

1990 • 153 citations

Thrombin and collagen induce rapid phosphorylation of a common set of cellular proteins on tyrosine in human platelets

1989 • 148 citations

Tyrosine Phosphorylation of Phospholipase C-II in Vitro by the Epidermal Growth Factor Receptor

1989 • 145 citations

A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets.

1989 • 141 citations

Erythropoietin induces p21ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells.

1992 • 139 citations

Phosphorylation of smg p21, a ras p21-like GTP-binding Protein, by Cyclic AMP-dependent Protein Kinase in a Cell-free System and in Response to Prostaglandin E1 in Intact Human Platelets

1989 • 110 citations

Thrombin stimulates the production of a novel polyphosphoinositide in human platelets.

1990 • 107 citations

Regulation of membrane-associated and cytosolic phospholipase C activities in human platelets by guanosine triphosphate.

1986 • 98 citations

Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets.

1988 • 90 citations

Rap1-b is phosphorylated by protein kinase a in intact human platelets

1990 • 90 citations

The signal transduction induced by thrombin in human platelets

1990 • 78 citations

PLC gamma 1, a possible mediator of T cell receptor function.

1991 • 73 citations

Expression of p60fyn in human platelets.

1990 • 70 citations

Partial purification of phosphoinositide phospholipase C from human platelet cytosol; characterization of its three forms

1986 • 70 citations

Platelet-Derived Growth Factor Induces Rapid and Sustained Tyrosine Phosphorylation of Phospholipase C-γ in Quiescent BALB/c 3T3 Cells

1989 • 60 citations

Resolution into two different forms and study of the properties of phosphatidylinositol-specific pospholipase C from human platelet cytosol

1982 • 57 citations

The Role of GTP-Binding Proteins in Platelet Activation

1991 • 53 citations

Platelet Tyrosine-Specific Protein Phosphorylation Is Regulated by Thrombin

1988 • 50 citations

Protein-Tyrosine Kinases Regulate the Phosphorylation, Protein Interactions, Subcellular Distribution, and Activity of p21^rasGTPase-Activating Protein

1991 • 50 citations

Effect of protein kinase A on inositide metabolism and rap 1 G-protein in human erythroleukemia cells.

1990 • 47 citations

Isolation and characterization of one soluble and two membrane-associated forms of phosphoinositide-specific phospholipase C from human platelets

1989 • 42 citations

Thrombolamban, the 22-kDa platelet substrate of cyclic AMP-dependent protein kinase, is immunologically homologous with the Ras family of GTP-binding proteins.

1990 • 38 citations

Epidermal growth factor and platelet‐derived growth factor promote translocation of phospholipase C‐γ from cytosol to membrane

1990 • 34 citations

Plasma membrane associated phospholipase C from human platelets: synergistic stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by thrombin and guanosine 5'-O-(3-thiotriphosphate)

1989 • 30 citations

Effects of guanosine 5′‐[γ‐thio]triphosphate and thrombin on the phosphoinositide metabolism of electropermeabilized human platelets

1988 • 22 citations

Platelet glycoprotein IIb–IIIa is associated with 21-kDa GTP-binding protein

1991 • 19 citations

Antisera specific for rap 1 proteins distinguish between processed and nonprocessed rap 1b

1991 • 18 citations