Phosphoinositide metabolism in resting and thrombin‐stimulated human platelets Evidence against metabolic heterogeneity

Thrombin-induced platelet responses differ in requirement for receptor occupancy. Evidence for tight coupling of occupancy and compartmentalized phosphatidic acid formation.

1981 • 101 citations

The relationship of hormone-sensitive and hormone-insensitive phosphatidylinositol to phosphatidylinositol 4,5-bisphosphate in the WRK-1 cell.

1986 • 98 citations

Changes in phosphatidylinositol-4,5-bisphosphate 10 seconds after stimulation of washed rabbit platelets with ADP

1982 • 95 citations

Tight coupling of thrombin-induced acid hydrolase secretion and phosphatidate synthesis to receptor occupancy in human platelets

1984 • 85 citations

Evidence for multiple metabolic pools of phosphatidylinositol in stimulated platelets.

1982 • 73 citations

The labelling of polyphosphoinositides with [32P]Pi and the accumulation of inositol phosphates in vasopressin-stimulated hepatocytes

1986 • 70 citations

Thin-layer chromatography of polyphosphoinositides from platelet extracts: Interference by an unknown phospholipid.

1985 • 68 citations

Turnover of phosphomonoester groups and compartmentation of polyphosphoinositides in human erythrocytes

1986 • 56 citations

The phosphoinositides exist in multiple metabolic pools in rabbit platelets

1986 • 47 citations

Changes in the platelet phosphoinositides during the first minute after stimulation of washed rabbit platelets with thrombin

1984 • 39 citations

Secretion, subcellular localization and metabolic status of inorganic pyrophosphate in human platelets. A major constituent of the amine-storing granules

1980 • 39 citations

The decrease in phosphatidylinositol 4,5-bisphosphate in ADP-stimulated washed rabbit platelets is not primarily due to phospholipase C activation

1986 • 37 citations

Determination of basal and stimulated levels of inositol triphosphate in [32P]orthophosphate-labeled platelets

1986 • 26 citations

Secretagogue-responsive and -unresponsive pools of phosphatidylinositol in pancreatic islets

1986 • 26 citations

Phosphate turnover of phosphatidylinositol in resting and thrombin-stimulated platelets

1986 • 21 citations

Manganese stimulates incorporation of [3H]inositol into an agonist — Insensitive pool of phosphatidylinositol in brain membranes

1985 • 21 citations

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