Hepatitis B Virus X and Regulation of Viral Gene Expression

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

2012 • 1,885 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

Epidemiology of Hepatocellular Carcinoma

2013 • 1,013 citations

Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells

1986 • 652 citations

The Enigmatic X Gene of Hepatitis B Virus

2004 • 486 citations

Woodchuck hepatitis virus X protein is required for viral infection in vivo

1994 • 443 citations

Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function

2009 • 443 citations

Hepatitis B Virus Replication Is Regulated by the Acetylation Status of Hepatitis B Virus cccDNA-Bound H3 and H4 Histones

2006 • 436 citations

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

1994 • 418 citations

DCAFs, the Missing Link of the CUL4-DDB1 Ubiquitin Ligase

2007 • 409 citations

Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection

2011 • 405 citations

Biology of Hepatitis B Virus

1981 • 394 citations

Mechanisms of HBV-related hepatocarcinogenesis

2010 • 394 citations

Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus

2001 • 391 citations

Calcium Signaling by HBx Protein in Hepatitis B Virus DNA Replication

2001 • 382 citations

The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks

1993 • 372 citations

Structural organization of the hepatitis B virus minichromosome

2001 • 331 citations

Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment

2010 • 326 citations

Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis

1997 • 322 citations

The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors.

1995 • 311 citations

Mitochondrially Associated Hepatitis B Virus X Protein Constitutively Activates Transcription Factors STAT-3 and NF-κB via Oxidative Stress

2001 • 310 citations

Hepatitis B Virus X Protein Colocalizes to Mitochondria with a Human Voltage-Dependent Anion Channel, HVDAC3, and Alters Its Transmembrane Potential

2000 • 306 citations

Modulation of allostery by protein intrinsic disorder

2013 • 305 citations

The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes

1995 • 303 citations

Aberrant Epigenetic Modifications in Hepatocarcinogenesis Induced by Hepatitis B Virus X Protein

2007 • 299 citations

Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases

1996 • 283 citations

Liver-Enriched Transcription Factors in Liver Function and Development. Part I: The Hepatocyte Nuclear Factor Network and Liver-Specific Gene Expression

2002 • 278 citations

Hepatitis B Virus X Protein Interferes with Cellular DNA Repair

1998 • 272 citations

Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation.

1995 • 263 citations

Hepatitis B Virus Disrupts Mitochondrial Dynamics: Induces Fission and Mitophagy to Attenuate Apoptosis

2013 • 263 citations

Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus

1997 • 261 citations

Hepatitis B Virus X Protein Induces Hepatic Steatosis Via Transcriptional Activation of SREBP1 and PPARγ

2007 • 257 citations

Hepatitis B virus X protein interacts with a probable cellular DNA repair protein

1995 • 249 citations

Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein

1999 • 243 citations

New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA

2004 • 238 citations

Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins

1996 • 237 citations

Activation of Src Family Kinases by Hepatitis B Virus HBx Protein and Coupled Signaling to Ras

1997 • 228 citations

Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle

2013 • 226 citations

The Hepatitis B Virus X Protein Disrupts Innate Immunity by Downregulating Mitochondrial Antiviral Signaling Protein

2010 • 224 citations

HeLa Cultures Defined

1976 • 223 citations

Cloning and Characterization of a Novel Hepatitis B Virus x Binding Protein That Inhibits Viral Replication

1998 • 220 citations

Store-operated Ca2+ entry depends on mitochondrial Ca2+ uptake

2002 • 210 citations

Liver-Enriched Transcription Factors in Liver Function and Development. Part II: the C/EBPs and D Site-Binding Protein in Cell Cycle Control, Carcinogenesis, Circadian Gene Regulation, Liver Regeneration, Apoptosis, and Liver-Specific Gene Regulation

2004 • 208 citations

Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication

1989 • 204 citations

Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C

1992 • 203 citations

A promiscuous α-helical motif anchors viral hijackers and substrate receptors to the CUL4–DDB1 ubiquitin ligase machinery

2009 • 202 citations

Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice

1990 • 196 citations

X-gene Product of Hepatitis B Virus Induces Apoptosis in Liver Cells

1998 • 194 citations

The Hepatitis B Virus X Protein Functionally Interacts with CREB-binding Protein/p300 in the Regulation of CREB-mediated Transcription

2006 • 194 citations

Hepatitis B virus transactivator protein X interacts with the TATA-binding protein.

1995 • 190 citations

Hepatitis B Virus X Protein Inhibits Transforming Growth Factor-β-induced Apoptosis through the Activation of Phosphatidylinositol 3-Kinase Pathway

2000 • 189 citations

Hepatitis B virus genome is organized into nucleosomes in the nucleus of the infected cell

1994 • 188 citations

Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death

1999 • 183 citations

Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virusX gene

1996 • 182 citations

The Hepatitis B Virus-X Protein Activates a Phosphatidylinositol 3-Kinase-dependent Survival Signaling Cascade

2001 • 181 citations

HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1

2007 • 181 citations

Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1

2005 • 180 citations

The Transcriptional Transactivation Function of HBx Protein Is Important for Its Augmentation Role in Hepatitis B Virus Replication

2005 • 180 citations

Molecular Determinants of Hepatitis B and D Virus Entry Restriction in Mouse Sodium Taurocholate Cotransporting Polypeptide

2013 • 178 citations

Expression of DNA Methyltransferase 1 Is Activated by Hepatitis B Virus X Protein via a Regulatory Circuit Involving the p16INK4a-Cyclin D1-CDK 4/6-pRb-E2F1 Pathway

2007 • 178 citations

Posttranscriptional regulation of hepatitis B virus replication by the precore protein

1997 • 177 citations

Enhancement of Hepatitis B Virus Replication by the Regulatory X Protein In Vitro and In Vivo

2006 • 169 citations

Hepatitis B Virus X Protein Enhances Transcriptional Activity of Hypoxia-inducible Factor-1α through Activation of Mitogen-activated Protein Kinase Pathway

2003 • 169 citations

X Protein of Hepatitis B Virus Inhibits Fas-mediated Apoptosis and Is Associated with Up-regulation of the SAPK/JNK Pathway

2001 • 168 citations

Hepadnaviral X protein: Review of recent progress

1996 • 161 citations

Hepatitis B Virus X Protein Is a Transcriptional Modulator That Communicates with Transcription Factor IIB and the RNA Polymerase II Subunit 5

1997 • 160 citations

The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters.

1990 • 159 citations

The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB.

1995 • 157 citations

Hepatitis B Virus X Protein Stimulates Viral Genome Replication via a DDB1-Dependent Pathway Distinct from That Leading to Cell Death

2005 • 156 citations

Hepatitis B Virus X Protein Induces Cell Death by Causing Loss of Mitochondrial Membrane Potential

2003 • 156 citations

Hepatitis B virus X protein is not central to the viral life cycle in vitro

1992 • 154 citations

The transcriptional function of the hepatitis B virus X protein and its role in hepatocarcinogenesis (Review).

1999 • 150 citations

Chapter 4 Hepatitis B Virus X Protein

2009 • 148 citations

Hepatitis B Virus pX Targets TFIIB in Transcription Coactivation

1998 • 145 citations

Structural and Functional Characterization of Interaction between Hepatitis B Virus X Protein and the Proteasome Complex

2000 • 141 citations

The hepatitis B virus encoded oncoprotein pX amplifies TGF-β family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis

2001 • 141 citations

Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal

2003 • 135 citations

The V Protein of the Paramyxovirus SV5 Interacts with Damage-Specific DNA Binding Protein

1998 • 134 citations

Autophagy Required for Hepatitis B Virus Replication in Transgenic Mice

2011 • 133 citations

Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice

2011 • 133 citations

Activation and Inhibition of Cellular Calcium and Tyrosine Kinase Signaling Pathways Identify Targets of the HBx Protein Involved in Hepatitis B Virus Replication

2003 • 128 citations

Enhancement of Hepatitis B Virus Replication by Its X Protein in Transgenic Mice

2002 • 126 citations

Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein.

1994 • 122 citations

Hepatitis B Virus HBx Protein Localizes to Mitochondria in Primary Rat Hepatocytes and Modulates Mitochondrial Membrane Potential

2008 • 119 citations

Hepatitis B Virus DNA Replication Is Coordinated by Core Protein Serine Phosphorylation and HBx Expression

2005 • 119 citations

Src kinases involved in hepatitis B virus replication

1999 • 118 citations

Ubiquitin proteasome system (UPS): what can chromatin do for you?

2007 • 115 citations

Simian Virus 5 V Protein Acts as an Adaptor, Linking DDB1 to STAT2, To Facilitate the Ubiquitination of STAT1

2005 • 109 citations

Blocking of G1/S transition and cell death in the regenerating liver of Hepatitis B virus X protein transgenic mice

2005 • 109 citations

Interaction of the UV-damaged DNA-binding protein with hepatitis B virus X protein is conserved among mammalian hepadnaviruses and restricted to transactivation-proficient X-insertion mutants

1997 • 109 citations

Caspase-dependent Alterations of Ca2+ Signaling in the Induction of Apoptosis by Hepatitis B Virus X Protein

2003 • 108 citations

Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription

2013 • 108 citations

Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome

1998 • 107 citations

The Hepatitis B Virus X Protein Modulates Hepatocyte Proliferation Pathways To Stimulate Viral Replication

2010 • 106 citations

Woodchuck hepatitis virus X protein is present in chronically infected woodchuck liver and woodchuck hepatocellular carcinomas which are permissive for viral replication

1996 • 105 citations

Viral Modulators of Cullin RING Ubiquitin Ligases: Culling the Host Defense

2006 • 103 citations

Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-κB

2001 • 102 citations

pX, the HBV-encoded coactivator, interacts with components of the transcription machinery and stimulates transcription in a TAF-independent manner.

1996 • 102 citations

HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice

2010 • 98 citations

The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway

1998 • 96 citations

Hepatitis B Virus X Protein Differentially Activates RAS-RAF-MAPK and JNK Pathways in X-transforming Versus Non-transforming AML12 Hepatocytes

2001 • 90 citations

An Unconventional Role for Cytoplasmic Disulfide Bonds in Vaccinia Virus Proteins

1999 • 89 citations

Sustained Activation of p38 Mitogen-Activated Protein Kinase and c-Jun N-Terminal Kinase Pathways by Hepatitis B Virus X Protein Mediates Apoptosis via Induction of Fas/FasL and Tumor Necrosis Factor (TNF) Receptor 1/TNF-α Expression

2004 • 89 citations

Hepatitis B Virus X Protein Induces Perinuclear Mitochondrial Clustering in Microtubule- and Dynein-Dependent Manners

2006 • 88 citations

The transactivation and p53-interacting functions of hepatitis B virus X protein are mutually interfering but distinct.

1997 • 87 citations

Regulation of RNA Polymerase I-Dependent Promoters by the Hepatitis B Virus X Protein via Activated Ras and TATA-Binding Protein

1998 • 85 citations

Interaction of Hepatitis B Viral X Protein and CCAAT/ Enhancer-binding Protein α Synergistically Activates the Hepatitis B Viral Enhancer II/Pregenomic Promoter

1999 • 83 citations

Hepatitis B Virus X Protein Modulates Apoptosis in Primary Rat Hepatocytes by Regulating both NF-κB and the Mitochondrial Permeability Transition Pore

2009 • 83 citations

Phosphorylation and rapid turnover of hepatitis B virus X-protein expressed in HepG2 cells from a recombinant vaccinia virus.

1991 • 81 citations

The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4

1998 • 81 citations

Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication

2012 • 80 citations

Hepatitis B Virus X Protein via the p38MAPK Pathway Induces E2F1 Release and ATR Kinase Activation Mediating p53 Apoptosis

2008 • 80 citations

Hepatitis B Virus X Protein induces RNA Polymerase III-Dependent Gene Transcription and Increases Cellular TATA-Binding Protein by Activating the Ras Signaling Pathway

1997 • 80 citations

The proapoptotic effect of hepatitis B virus HBx protein correlates with its transactivation activity in stably transfected cell lines

1999 • 80 citations

Alternate translation initiation on hepatitis B virus X mRNA produces multiple polypeptides that differentially transactivate class II and III promoters

1992 • 78 citations

Hepatitis B virus X protein stimulates gene expression selectively from extrachromosomal DNA templates

2012 • 76 citations

A Structural Basis for the Assembly and Functions of a Viral Polymer that Inactivates Multiple Tumor Suppressors

2012 • 75 citations

The Hepatitis B Virus X Protein Elevates Cytosolic Calcium Signals by Modulating Mitochondrial Calcium Uptake

2011 • 75 citations

Hepatitis B Virus X Protein Differentially Regulates Cell Cycle Progression in X-transforming Versus Nontransforming Hepatocyte (AML12) Cell Lines

2002 • 73 citations

Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: An alternative mechanism of HBx-related pathogenesis

2002 • 71 citations

Molecular biology of the hepatitis B virus and role of the X gene

2010 • 70 citations

The Hepatitis B Virus X Protein Increases the Cellular Level of TATA-Binding Protein, Which Mediates Transactivation of RNA Polymerase III Genes

1995 • 69 citations

X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo

2001 • 65 citations

Stimulation of Cellular Proliferation by Hepatitis B Virus X Protein

2001 • 65 citations

Replication of the hepatitis B virus requires a calcium-dependent HBx-induced G1 phase arrest of hepatocytes

2010 • 64 citations

Long-term expression of the hepatitis B virus core-e- and X-proteins does not cause pathologic changes in transgenic mice

1997 • 63 citations

X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo

2001 • 62 citations

Modulation of Apoptotic Signaling by the Hepatitis B Virus X Protein

2012 • 62 citations

Sodium Taurocholate Cotransporting Polypeptide Mediates Woolly Monkey Hepatitis B Virus Infection of Tupaia Hepatocytes

2013 • 61 citations

Turnover of Hepatitis B Virus X Protein Is Regulated by Damaged DNA-Binding Complex

2002 • 61 citations

Hepatitis B Virus X Protein Activates the p38 Mitogen-Activated Protein Kinase Pathway in Dedifferentiated Hepatocytes

2002 • 60 citations

Viral Genomes - Molecular Structure, Diversity, Gene Expression Mechanisms and Host-Virus Interactions

2012 • 58 citations

In vivo activity of the hepatitis B virus core promoter: tissue specificity and temporal regulation

1995 • 55 citations

Inhibition of PP1 Phosphatase Activity by HBx: A Mechanism for the Activation of Hepatitis B Virus Transcription

2012 • 55 citations

Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replication

2011 • 54 citations

Evaluation of Transcriptional Efficiency of Hepatitis B Virus Covalently Closed Circular DNA by Reverse Transcription-PCR Combined with the Restriction Enzyme Digestion Method

2005 • 53 citations

Deregulation of DNA Damage Signal Transduction by Herpesvirus Latency-Associated M2

2006 • 51 citations

Hepatitis B virus X gene product acts as a transactivator in vivo

1994 • 49 citations

Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis

2003 • 48 citations

A Stable α-Helical Domain at the N Terminus of the RIα Subunits of cAMP-dependent Protein Kinase Is a Novel Dimerization/Docking Motif

1997 • 47 citations

Isolation and molecular characterization of hepatitis B virus X-protein from a baculovirus expression system

1997 • 47 citations

Human Immunodeficiency Virus Type 1 Vpr Links Proteasomal Degradation and Checkpoint Activation

2007 • 47 citations

Mechanism for CCC DNA Synthesis in Hepadnaviruses

2009 • 45 citations

HBX causes cyclin D1 overexpression and development of breast cancer in transgenic animals that are heterozygous for p53

2003 • 43 citations

Virus replication and virion export in X-deficient hepatitis B virus transgenic mice

2002 • 39 citations

SAGE transcript profiles of normal primary human hepatocytes expressing oncogenic hepatitis B virus X protein

2002 • 35 citations

Structural Characterization of an Intrinsically Unfolded Mini-HBX Protein from Hepatitis B Virus

2012 • 33 citations

Premature Cell Cycle Entry Induced by Hepatitis B Virus Regulatory HBx Protein during Compensatory Liver Regeneration

2008 • 33 citations

Akt augments the oncogenic potential of the HBx protein of hepatitis B virus by phosphorylation

2012 • 32 citations

The C-terminal region of the hepatitis B virus X protein is essential for its stability and function

2010 • 32 citations

The Oncogenic Role of Hepatitis B Virus

2013 • 32 citations

Upregulation of DNMT1 mediated by HBx suppresses RASSF1A expression independent of DNA methylation

2013 • 31 citations

Protein X of Hepatitis B Virus: Origin and Structure Similarity with the Central Domain of DNA Glycosylase

2011 • 31 citations

The hepatitis B virus HBx protein modulates cell cycle regulatory proteins in cultured primary human hepatocytes

2010 • 31 citations

The Hepatitis B Virus X Protein Transactivates Viral Core Gene Expression In Vivo

1999 • 31 citations

Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein

2006 • 30 citations

Deregulation of Epigenetic Mechanisms by the Hepatitis B Virus X Protein in Hepatocarcinogenesis

2013 • 30 citations

The Hepatitis B pX Protein Promotes Dimerization and DNA Binding of Cellular Basic Region/Leucine Zipper Proteins by Targeting the Conserved Basic Region

1999 • 29 citations

Gene expression profiles of human liver cells mediated by hepatitis B virus X protein

2009 • 28 citations

Dimerization of hepatitis B viral X protein synthesized in a cell-free system

1989 • 27 citations

The cysteine residues of the hepatitis B virus onco-protein HBx are not required for its interaction with RNA or with human p53

2004 • 18 citations

Gene expression profiles of human liver cells mediated by hepatitis B virus X protein

2009 • 18 citations

Hepatitis B Virus X Protein: Structure-Function Relationships and Role in Viral Pathogenesis

2004 • 16 citations

Recruiting Substrates to Cullin 4-Dependent Ubiquitin Ligases by DDB1

2004 • 15 citations

Modulation of Cell Proliferation Pathways by the Hepatitis B Virus X Protein: A Potential Contributor to the Development of Hepatocellular Carcinoma

2012 • 12 citations

Bioluminescence imaging of hepatitis B virus enhancer and promoter activities in mice

2008 • 10 citations

Isolation and molecular characterization of hepatitis B virus X-protein from a baculovirus expression system

1997 • 9 citations

The viral transactivator HBx protein exhibits a high potential for regulation via phosphorylation through an evolutionarily conserved mechanism

2012 • 8 citations

Hepatitis B Virus X Protein: A Key Regulator of the Virus Life Cycle

2012 • 4 citations

The hepatitis B virus X protein elevates cytosolic calcium signals by modulating mitochondrial calcium uptake

2011 • 4 citations

Transcriptional Activation by the Hepatitis B Virus X Protein

1993 • 3 citations