Transcriptional Activation by the Hepatitis B Virus X Protein

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

1981 • 2,891 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

PROTEIN-DNA RECOGNITION

1984 • 1,649 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

The hepatitis B virus

1985 • 1,219 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

THE MOLECULAR BIOLOGY OF THE HEPATITIS B VIRUSES

1987 • 1,046 citations

Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of Yeast

1986 • 946 citations

Zinc fingers: Gilt by association

1988 • 799 citations

THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS

1989 • 739 citations

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

1989 • 692 citations

A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks.

1978 • 657 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus

1980 • 506 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma

1986 • 399 citations

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein

1990 • 391 citations

Immunobiology and Pathogenesis of Hepatocellular Injury in Hepatitis B Virus Transgenic Mice

1990 • 363 citations

DETECTION OF HEPATITIS B VIRUS DNA IN LIVER AND SERUM: A DIRECT APPRAISAL OF THE CHRONIC CARRIER STATE

1981 • 333 citations

Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter.

1989 • 317 citations

trans-activation of viral enhancers by the hepatitis B virus X protein

1988 • 316 citations

The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator

1990 • 284 citations

Mutants of GAL4 protein altered in an activation function

1987 • 281 citations

Transcriptional trans-activating function of hepatitis B virus

1987 • 280 citations

A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain with the E2 transactivator

1987 • 278 citations

Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors

1990 • 247 citations

Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA.

1990 • 236 citations

Evidence for interaction of different eukaryotic transcriptional activators with distinct cellular targets

1990 • 221 citations

In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.

1989 • 220 citations

Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein.

1988 • 212 citations

Common evolutionary origin of hepatitis B virus and retroviruses.

1986 • 204 citations

Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication

1989 • 204 citations

Activation of transcription factor IIIC by the adenovirus E1A protein

1988 • 197 citations

Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice

1990 • 196 citations

Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor.

1990 • 193 citations

Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma

1988 • 192 citations

Enhancement of RNA polymerase III transcription by the E1A gene product of adenovirus

1985 • 188 citations

Relation of the hepatitis B virus carrier state to hepatocellular carcinoma

1987 • 186 citations

ADENOVIRUS E1A PROTEIN PARADIGM VIRAL TRANSACTIVATOR

1989 • 184 citations

Interleukin 1 and cyclic AMP induce kappa immunoglobulin light-chain expression via activation of an NF-kappa B-like DNA-binding protein.

1989 • 176 citations

The HBV X-ORF encodes a transactivator: a potential factor in viral hepatocarcinogenesis.

1988 • 161 citations

The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters.

1990 • 159 citations

Adenovirus stimulation of transcription by RNA polymerase III: evidence for an E1A-dependent increase in transcription factor IIIC concentration.

1986 • 156 citations

trans-Activation of viral enhancers including long terminal repeat of the human immunodeficiency virus by the hepatitis B virus X protein

1989 • 145 citations

A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA.

1990 • 145 citations

Hepatitis B virus X gene can transactivate heterologous viral sequences.

1989 • 137 citations

Expression of the hepatitis B virus X gene in mammalian cells.

1987 • 131 citations

The hepatitis B virus-encoded transcriptional trans-activator hbx appears to be a novel protein serine/threonine kinase

1990 • 121 citations

The HBV HBX gene expressed in E. coli is recognised by sera from hepatitis patients.

1985 • 99 citations

Trans-activation of RNA polymerase II and III promoters by SV40 small t antigen

1988 • 98 citations

Phorbol-ester-induced Activation of the NF- B Transcription Factor Involves Dissociation of an Apparently Cytoplasmic NF- B/Inhibitor Complex

1988 • 94 citations

Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C.

1990 • 88 citations

Hepatitis B virus polypeptide X: expression in Escherichia coli and identification of specific antibodies in sera from hepatitis B virus-infected humans

1986 • 75 citations

Transcription factor phosphorylation: a link between signal transduction and the regulation of gene expression.

1990 • 71 citations

Regulation of RNA polymerase III transcription in response to Simian virus 40 transformation.

1990 • 62 citations

Detection of hepatitis B virus X product using an open reading frame Escherichia coli expression vector.

1986 • 44 citations

Hepatitis B virus (HBV) X gene expression in human cells and anti-HBx antibodies detection in chronic HBV infection

1990 • 42 citations

Hepatitis B virus X protein produced in Escherichia coli is biologically functional

1990 • 31 citations

A lack of direct role of hepatitis B virus in the activation of ras and c-myc oncogenes in human hepatocellular carcinogenesis

1988 • 31 citations

Activator's target in sight

1989 • 28 citations

Characteristics of the X gene of hepatitis B virus

1988 • 28 citations

Cyclic AMP-Independent Activation of Transcription Factor NF-κB in HL60 Cells by Tumor Necrosis Factors α and β

1991 • 26 citations

Low incidence and high titers of antibodies to hepatitis B virus X‐Protein in sera of chinese patients with hepatocellular carcinoma

1988 • 15 citations

Cyclic AMP-independent activation of transcription factor NF-kappa B in HL60 cells by tumor necrosis factors alpha and beta.

1991 • 14 citations

Deleted Work

1955 • 0 citations