Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis

Hepatitis B virus.The major etiology of hepatocellular carcinoma

1988 • 1,308 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

Hepatocellular carcinoma

2000 • 430 citations

Calcium Signaling by HBx Protein in Hepatitis B Virus DNA Replication

2001 • 382 citations

Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway

1993 • 371 citations

Genetic mechanisms of hepatocarcinogenesis

2002 • 332 citations

The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors.

1995 • 311 citations

Hepatitis B Virus X Protein Colocalizes to Mitochondria with a Human Voltage-Dependent Anion Channel, HVDAC3, and Alters Its Transmembrane Potential

2000 • 306 citations

The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice

1997 • 286 citations

High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice

1994 • 277 citations

Molecular pathogenesis of human hepatocellular carcinoma

2002 • 259 citations

Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma

1995 • 249 citations

Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein

1999 • 243 citations

Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma.

1997 • 228 citations

Hepatitis B Virus X Protein Is both a Substrate and a Potential Inhibitor of the Proteasome Complex

1999 • 227 citations

Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice

1990 • 196 citations

“Slow-down” of the intrahepatic bile duct development between the 2nd and the 3rd trimester of gestation

2000 • 189 citations

Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death

1999 • 183 citations

Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virusX gene

1996 • 182 citations

X Protein of Hepatitis B Virus Inhibits Fas-mediated Apoptosis and Is Associated with Up-regulation of the SAPK/JNK Pathway

2001 • 168 citations

Hepatitis B Virus X Protein Induces Cell Death by Causing Loss of Mitochondrial Membrane Potential

2003 • 156 citations

Reliable stereological method for estimating the number of microscopic hepatocellular foci from their transections.

1983 • 152 citations

Hepatitis B Virus X Protein Acts as a Tumor Promoter in Development of Diethylnitrosamine-Induced Preneoplastic Lesions

2001 • 117 citations

Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome

1998 • 107 citations

Woodchuck hepatitis virus X protein is present in chronically infected woodchuck liver and woodchuck hepatocellular carcinomas which are permissive for viral replication

1996 • 105 citations

Distinctive gene expression profiles associated with Hepatitis B virus x protein

2001 • 97 citations

Hepatitis B Virus X Protein Associated with UV-DDB1 Induces Cell Death in the Nucleus and Is Functionally Antagonized by UV-DDB2

2002 • 64 citations

Long-term expression of the hepatitis B virus core-e- and X-proteins does not cause pathologic changes in transgenic mice

1997 • 63 citations

Hepatitis B Virus X Protein Activates the p38 Mitogen-Activated Protein Kinase Pathway in Dedifferentiated Hepatocytes

2002 • 60 citations

In vivo activity of the hepatitis B virus core promoter: tissue specificity and temporal regulation

1995 • 55 citations

Expression of Hepatitis B Virus X Protein Does Not Alter the Accumulation of Spontaneous Mutations in Transgenic Mice

2000 • 54 citations

Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma*1

1995 • 53 citations

Hepatitis B virus X gene product acts as a transactivator in vivo

1994 • 49 citations

Recognition efficiency of the hepatitis B virus polyadenylation signals is tissue specific in transgenic mice

1992 • 35 citations

Through Induction of Juxtaposition and Tyrosine Kinase Activity of Jak1, X-Gene Product of Hepatitis B Virus Stimulates Ras and the Transcriptional Activation through AP-1, NF-κB, and SRE Enhancers

2001 • 27 citations

Preliminary study on the production of transgenic mice harboring hepatitis B virusXgene

1998 • 8 citations