Enhancement of Hepatitis B Virus Replication by Its X Protein in Transgenic Mice

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

High-level hepatitis B virus replication in transgenic mice

1995 • 625 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

Woodchuck hepatitis virus X protein is required for viral infection in vivo

1994 • 443 citations

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

1994 • 418 citations

The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks

1993 • 372 citations

Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis

1997 • 322 citations

trans-activation of viral enhancers by the hepatitis B virus X protein

1988 • 316 citations

The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors.

1995 • 311 citations

Hepatitis B Virus X Protein Colocalizes to Mitochondria with a Human Voltage-Dependent Anion Channel, HVDAC3, and Alters Its Transmembrane Potential

2000 • 306 citations

Hepatitis B Virus X Protein Interferes with Cellular DNA Repair

1998 • 272 citations

Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation.

1995 • 263 citations

Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors

1990 • 247 citations

Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein.

1988 • 212 citations

Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C

1992 • 203 citations

The hepatitis B virus X gene induces p53-mediated programmed cell death

1997 • 199 citations

Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice

1990 • 196 citations

Hepatitis B virus transactivator protein X interacts with the TATA-binding protein.

1995 • 190 citations

Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virusX gene

1996 • 182 citations

Proteasome complex as a potential cellular target of hepatitis B virus X protein

1996 • 170 citations

Hepadnaviral X protein: Review of recent progress

1996 • 161 citations

Hepatitis B Virus X Protein Is a Transcriptional Modulator That Communicates with Transcription Factor IIB and the RNA Polymerase II Subunit 5

1997 • 160 citations

Hepatitis B virus X protein is not central to the viral life cycle in vitro

1992 • 154 citations

Hepatitis B Virus pX Targets TFIIB in Transcription Coactivation

1998 • 145 citations

Type, prevalence, and significance of core promoter/enhancer II mutations in hepatitis B viruses from immunosuppressed patients with severe liver disease

1996 • 136 citations

Ras- and Raf-dependent activation of c-jun transcriptional activity by the hepatitis B virus transactivator pX.

1994 • 128 citations

Src kinases involved in hepatitis B virus replication

1999 • 118 citations

HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteasome alpha-subunit

1995 • 92 citations

Regulation of RNA Polymerase I-Dependent Promoters by the Hepatitis B Virus X Protein via Activated Ras and TATA-Binding Protein

1998 • 85 citations

Hepatitis B Virus X Protein induces RNA Polymerase III-Dependent Gene Transcription and Increases Cellular TATA-Binding Protein by Activating the Ras Signaling Pathway

1997 • 80 citations

Identification of a region within the human immunodeficiency virus type 1 long terminal repeat that is essential for transactivation by the hepatitis B virus gene X

1989 • 68 citations

X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo

2001 • 65 citations

X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo

2001 • 62 citations

Pro-apoptotic effect of the hepatitis B virus X gene

1998 • 52 citations

Pathogenesis of posttransfusion viral hepatitis in children with β-thalassemia

1994 • 45 citations

Different Regions of Hepatitis B Virus X Protein Are Required for Enhancement of bZip-Mediated Transactivation versus Transrepression

2000 • 38 citations

The Hepatitis B Virus X Protein Transactivates Viral Core Gene Expression In Vivo

1999 • 31 citations

Control of Expression and Methylation of a Hepatitis B Virus Transgene by Strain-Specific Modifiers

1998 • 23 citations

Correlation of Tissue‐specific Methylation with Gene Inactivity in Hepatitis B Virus Transgenic Mice

1990 • 9 citations