The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Hepatitis B Virus Immunopathogenesis

1995 • 1,568 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

The hepatitis B virus

1985 • 1,219 citations

THE MOLECULAR BIOLOGY OF THE HEPATITIS B VIRUSES

1987 • 1,046 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

1996 • 692 citations

Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction

1992 • 675 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

Lipopolysaccharide Induction of the Tumor Necrosis Factor-α Promoter in Human Monocytic Cells

1997 • 466 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

1994 • 418 citations

Effects of cytokines on the liver

1991 • 409 citations

Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway

1993 • 371 citations

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

1995 • 347 citations

Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.

1993 • 344 citations

The T Cell Activation Factor NF-ATc Positively Regulates HIV-1 Replication and Gene Expression in T Cells

1997 • 313 citations

The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors.

1995 • 311 citations

Calcineurin Binds the Transcription Factor NFAT1 and Reversibly Regulates Its Activity

1996 • 300 citations

Chronic Tumor Necrosis Factor Alters T Cell Responses by Attenuating T Cell Receptor Signaling

1997 • 287 citations

Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases

1996 • 283 citations

Induction of tumor necrosis factor alpha production by human hepatocytes in chronic viral hepatitis.

1994 • 267 citations

Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation.

1995 • 263 citations

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

1995 • 258 citations

Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins

1996 • 237 citations

Activation of Src Family Kinases by Hepatitis B Virus HBx Protein and Coupled Signaling to Ras

1997 • 228 citations

Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elements

1991 • 224 citations

The NFAT-1 DNA Binding Complex in Activated T Cells Contains Fra-1 and JunB

1993 • 215 citations

The hepatitis B virus X gene induces p53-mediated programmed cell death

1997 • 199 citations

Hepatitis B virus transactivator protein X interacts with the TATA-binding protein.

1995 • 190 citations

Cell-Type-Specific Regulation of the Human Tumor Necrosis Factor Alpha Gene in B Cells and T Cells by NFATp and ATF-2/JUN

1996 • 189 citations

Expression of NFAT-Family Proteins in Normal Human T Cells

1997 • 176 citations

Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import.

1996 • 173 citations

Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis.

1996 • 167 citations

Hepadnaviral X protein: Review of recent progress

1996 • 161 citations

Hepatitis B Virus X Protein Is a Transcriptional Modulator That Communicates with Transcription Factor IIB and the RNA Polymerase II Subunit 5

1997 • 160 citations

Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases.

1993 • 160 citations

A common factor regulates both Th1- and Th2-specific cytokine gene expression.

1994 • 151 citations

Hepatitis B virus pX activates NF-kappa B-dependent transcription through a Raf-independent pathway

1996 • 150 citations

Transcriptional activation of the human TNF-alpha promoter by superantigen in human monocytic cells: role of NF-kappa B.

1995 • 146 citations

Hepatitis B Virus pX Targets TFIIB in Transcription Coactivation

1998 • 145 citations

Characterization of Antigen Receptor Response Elements within the Interleukin-2 Enhancer

1988 • 143 citations

The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.

1994 • 140 citations

Human Granulocyte-Macrophage Colony-Stimulating Factor Enhancer Function Is Associated with Cooperative Interactions between AP-1 and NFATp/c

1995 • 133 citations

Ras- and Raf-dependent activation of c-jun transcriptional activity by the hepatitis B virus transactivator pX.

1994 • 128 citations

Induction of the DNA-Binding Activity of c-Jun/c-Fos Heterodimers by the Hepatitis B Virus Transactivator pX

1994 • 127 citations

The hepatitis B virus X protein up-regulates tumor necrosis factor α gene expression in hepatocytes

1998 • 119 citations

The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB.

1993 • 105 citations

pX, the HBV-encoded coactivator, interacts with components of the transcription machinery and stimulates transcription in a TAF-independent manner.

1996 • 102 citations

Mechanisms of transactivation by nuclear factor of activated T cells-1.

1996 • 100 citations

Transferrin receptor mediates uptake and presentation of hepatitis B envelope antigen by T lymphocytes.

1992 • 98 citations

Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets.

1995 • 92 citations

The X Protein of Hepatitis B Virus Coactivates Potent Activation Domains

1995 • 88 citations

Hepatitis B Virus HBx Gene and Hepatocarcinogenesis

1995 • 81 citations

Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX.

1994 • 80 citations

Cytokine mRNA expression in the liver of patients with primary biliary cirrhosis (PBC) and chronic hepatitis B (CHB)

1996 • 69 citations

Activation of the IL-2 gene promoter by HTLV-I tax involves induction of NF-AT complexes bound to the CD28-responsive element.

1996 • 69 citations

Blockade of T-Cell Activation by Dithiocarbamates Involves Novel Mechanisms of Inhibition of Nuclear Factor of Activated T Cells

1997 • 59 citations

Transactivation of Human Hepatitis B Virus X Protein, HBx, Operates through a Mechanism Distinct from Protein Kinase C and Okadaic Acid Activation Pathways

1994 • 55 citations

Activation of Nuclear Factor of Activated T Cells in a Cyclosporin A-resistant Pathway

1996 • 50 citations

Expression rate of cytokine mRNA in the liver of chronic hepatitis C: Comparison with chronic hepatitis B

1995 • 47 citations

Constitutive Dephosphorylation and Activation of a Member of the Nuclear Factor of Activated T Cells, NF-AT1, in Tax-expressing and Type I Human T-cell Leukemia Virus-infected Human T Cells

1997 • 29 citations

Autopresentation of hepatitis B virus envelope antigens by T cells

1992 • 13 citations