Hepatitis B Virus X Protein Enhances Transcriptional Activity of Hypoxia-inducible Factor-1α through Activation of Mitogen-activated Protein Kinase Pathway

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

2002 • 1,512 citations

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

2002 • 1,472 citations

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

2001 • 1,326 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

2000 • 1,087 citations

Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia

1995 • 1,087 citations

Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

2000 • 1,018 citations

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development

1997 • 1,004 citations

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

2001 • 917 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

2000 • 893 citations

Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor protein

2000 • 889 citations

p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1

1999 • 777 citations

Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway

1999 • 744 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

1998 • 653 citations

Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

2000 • 635 citations

Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1 alpha ) in vascular smooth muscle cells

2000 • 592 citations

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300

1999 • 583 citations

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha /ARNT

1998 • 561 citations

Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element

1997 • 501 citations

Nonhypoxic Pathway Mediates the Induction of Hypoxia-inducible Factor 1α in Vascular Smooth Muscle Cells

2000 • 465 citations

The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.

2000 • 452 citations

Oxygenation status of malignant tumors: Pathogenesis of hypoxia and significance for tumor therapy

2001 • 446 citations

ERK activation upon hypoxia: involvement in HIF‐1 activation

2000 • 365 citations

Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.

2001 • 315 citations

Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases

1996 • 283 citations

Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation

2000 • 274 citations

Vascular endothelial growth factor: its prognostic, predictive, and therapeutic implications

2001 • 265 citations

Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein

1999 • 243 citations

Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer.

1998 • 231 citations

Hepatitis B Virus X Protein Is both a Substrate and a Potential Inhibitor of the Proteasome Complex

1999 • 227 citations

Oncogenes and tumor angiogenesis: the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner

2000 • 219 citations

VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma

2001 • 218 citations

Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression

1997 • 202 citations

X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis

2001 • 154 citations

Gene transfer of antisense hypoxia inducible factor-1 α enhances the therapeutic efficacy of cancer immunotherapy

2001 • 144 citations

Structural and Functional Characterization of Interaction between Hepatitis B Virus X Protein and the Proteasome Complex

2000 • 141 citations

The molecular basis of the hypoxia response pathway: tumour hypoxia as a therapy target.

1998 • 131 citations

Mitogen-Activated Protein Kinase Kinase Inhibitor PD98059 Blocks thetrans-Activation but Not the Stabilization or DNA Binding Ability of Hypoxia-Inducible Factor-1α

2001 • 110 citations

Human Hepatitis B Virus X Protein Is a Possible Mediator of Hypoxia-Induced Angiogenesis in Hepatocarcinogenesis

2000 • 103 citations

Fas/Fas Ligand Interaction in Human Colorectal Hepatic Metastases

1999 • 96 citations

The transactivation and p53-interacting functions of hepatitis B virus X protein are mutually interfering but distinct.

1997 • 87 citations

The hepatitis B virus X protein (HBx) induces a migratory phenotype in a CD44-dependent manner: Possible role of HBx in invasion and metastasis

2001 • 85 citations

Effect of the hepatitis B virus HBx protein on integrin-mediated adhesion to and migration on extracellular matrix

2001 • 75 citations

NF-κB activation by hepatitis B virus X (HBx) protein shifts the cellular fate toward survival

2002 • 71 citations

Increased proliferation activities of vascular endothelial cells and tumour cells in residual hepatocellular carcinoma following transcatheter arterial embolization

2001 • 64 citations

Hepatitis B virus X protein induced expression of interleukin 18 (IL-18): a potential mechanism for liver injury caused by hepatitis B virus (HBV) infection

2002 • 62 citations

Binding and regulation of HIF‐1α by a subunit of the proteasome complex, PSMA7

2001 • 61 citations

Enhanced expression of vascular endothelial growth factor (VEGF) plays a critical role in the tumor progression potential induced by simian virus 40 large T antigen

2002 • 60 citations

Serum vascular endothelial growth factor in the course of transcatheter arterial embolization of hepatocellular carcinoma.

1999 • 58 citations

Hepatitis B virus-induced hepatocellular carcinoma: possible roles for HBx

1996 • 49 citations

Insulin-like growth factor II (IGF-II) secreted from HepG2 human hepatocellular carcinoma cells shows angiogenic activity

1998 • 49 citations

Chemotherapeutic drug, adriamycin, restores the function of p53 protein in hepatitis B virus X (HBx) protein-expressing liver cells

2000 • 44 citations

Hepatitis B Virus X Protein Induced Expression of the Nur77 Gene

2001 • 32 citations

Deleted Work

1955 • 0 citations