Liver-Enriched Transcription Factors in Liver Function and Development. Part II: the C/EBPs and D Site-Binding Protein in Cell Cycle Control, Carcinogenesis, Circadian Gene Regulation, Liver Regeneration, Apoptosis, and Liver-Specific Gene Regulation

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

2000 • 2,232 citations

Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats

2000 • 1,844 citations

Transplanted Suprachiasmatic Nucleus Determines Circadian Period

1990 • 1,788 citations

Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling

2000 • 1,733 citations

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

1991 • 1,684 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

CCAAT/enhancer-binding proteins: structure, function and regulation

2002 • 1,355 citations

Positional Cloning of the Mouse Circadian Gene

1997 • 1,335 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 • 893 citations

Sumo, ubiquitin's mysterious cousin

2001 • 749 citations

CCAAT-Enhancer Binding Protein: A Component of a Differentiation Switch

1991 • 733 citations

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

1989 • 698 citations

Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue

1997 • 664 citations

Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein.

1989 • 641 citations

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to CEBP

1990 • 637 citations

LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.

1990 • 599 citations

Expression of CYP3A in the Human Liver — Evidence that the Shift between CYP3A7 and CYP3A4 Occurs Immediately After Birth

1997 • 530 citations

Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction.

1993 • 530 citations

Comparative Metabolic Capabilities of CYP3A4, CYP3A5, and CYP3A7

2002 • 452 citations

Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)–ATF composite site to regulate Gadd153 expression during the stress response

1999 • 445 citations

CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP

2000 • 418 citations

DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally

1990 • 410 citations

Molecular basis of transdifferentiation of pancreas to liver

2000 • 408 citations

Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter

1987 • 407 citations

Distinct Mechanisms for Regulation of the Interleukin-8 Gene Involve Synergism and Cooperativity between C/EBP and NF-κB

1993 • 400 citations

CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein.

1996 • 393 citations

ER quality control: towards an understanding at the molecular level

2001 • 392 citations

CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials.

1993 • 372 citations

Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain

1993 • 345 citations

C/EBPα Arrests Cell Proliferation through Direct Inhibition of Cdk2 and Cdk4

2001 • 344 citations

Initiation of acute phase response and synthesis of cytokines

1996 • 338 citations

Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions.

1992 • 327 citations

Expression of the Peroxisome Proliferator-activated Receptor α Gene Is Stimulated by Stress and Follows a Diurnal Rhythm

1996 • 317 citations

A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity.

1993 • 313 citations

Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response.

1992 • 313 citations

Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP.

1993 • 293 citations

The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior

1997 • 291 citations

Fusion of the Leucine Zipper Gene HLF to the E2A Gene in Human Acute B-Lineage Leukemia

1992 • 290 citations

Liver-Enriched Transcription Factors in Liver Function and Development. Part I: The Hepatocyte Nuclear Factor Network and Liver-Specific Gene Expression

2002 • 278 citations

Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family.

1990 • 274 citations

Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP.

1990 • 272 citations

C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements.

1993 • 272 citations

Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-kappa B.

1993 • 254 citations

TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins.

1991 • 246 citations

Cognate DNA Binding Specificity Retained After Leucine Zipper Exchange Between GCN4 and C/EBP

1989 • 237 citations

CCAAT/Enhancer Binding Protein α Regulates p21 Protein and Hepatocyte Proliferation in Newborn Mice

1997 • 236 citations

Role of the multifunctional CDP/Cut/Cux homeodomain transcription factor in regulating differentiation, cell growth and development

2001 • 235 citations

Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia.

1992 • 234 citations

Tumor Necrosis Factor Alpha and Interleukin-1β Regulate the Murine Manganese Superoxide Dismutase Gene Through a Complex Intronic Enhancer Involving C/EBP-β and NF-κB

1997 • 231 citations

Physical isolation of nascent RNA chains transcribed by RNA polymerase II: evidence for cotranscriptional splicing.

1994 • 230 citations

CRP2 (C/EBP beta) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity.

1995 • 230 citations

Expression of hepatic transcription factors during liver development and oval cell differentiation.

1994 • 230 citations

Dissecting glycoprotein quality control in the secretory pathway

2001 • 226 citations

Novel mechanism of C/EBP beta (NF-M) transcriptional control: activation through derepression.

1994 • 225 citations

Expression of the liver-enriched transcriptional activator protein DBP follows a stringent circadian rhythm

1990 • 218 citations

Amino Acid Limitation Induces Expression of CHOP, a CCAAT/Enhancer Binding Protein-related Gene, at Both Transcriptional and Post-transcriptional Levels

1997 • 203 citations

Induction of the mammalian stress response gene GADD153 by oxidative stress: role of AP-1 element

1996 • 202 citations

Molecular Neurobiology and Genetics of Circadian Rhythms in Mammals

1995 • 198 citations

Expression profiling suggested a regulatory role of liver-enriched transcription factors in human hepatocellular carcinoma.

2001 • 194 citations

Regulation of the C/EBP-related gene gadd153 by glucose deprivation.

1993 • 190 citations

CREB Controls LAP/C/EBPβ Transcription

1997 • 189 citations

Disruption of the c/ebpα Gene in Adult Mouse liver

1997 • 180 citations

The two C/EBP isoforms, IL6DBP/NFIL6 and CEBP6δ/NFIL63, are induced by IL6β to promote acute phase gene transcription via different mechanisms

1993 • 176 citations

C/EBPα Inhibits Cell Growth via Direct Repression of E2F-DP-Mediated Transcription

2000 • 172 citations

CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBP mRNA and regulates translation of C/EBP isoforms

1999 • 170 citations

C/EBPβ Phosphorylation by RSK Creates a Functional XEXD Caspase Inhibitory Box Critical for Cell Survival

2001 • 166 citations

Phosphorylation of Rat Serine 105 or Mouse Threonine 217 in C/EBPβ Is Required for Hepatocyte Proliferation Induced by TGFα

1999 • 165 citations

Circadian Expression of the Steroid 15 α-Hydroxylase (Cyp2a4) and Coumarin 7-Hydroxylase (Cyp2a5) Genes in Mouse Liver Is Regulated by the PAR Leucine Zipper Transcription Factor DBP

1999 • 163 citations

CCAAT/enhancer binding protein-alpha amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells.

1995 • 157 citations

Rat liver cholesterol 7 alpha-hydroxylase. Pretranslational regulation for circadian rhythm.

1990 • 157 citations

Autoregulation of the Human C/EBPα Gene by Stimulation of Upstream Stimulatory Factor Binding

1995 • 156 citations

Evidence for Posttranscriptional Regulation of C/EBPα and C/EBPβ Isoform Expression during the Lipopolysaccharide-Mediated Acute-Phase Response†

1996 • 155 citations

The role of proteomics in toxicology: identification of biomarkers of toxicity by protein expression analysis

2002 • 155 citations

gadd153/Chop10, a Potential Target Gene of the Transcriptional Repressor ATF3

1997 • 155 citations

Growth-dependent inhibition of CCAAT enhancer-binding protein (C/EBP alpha) gene expression during hepatocyte proliferation in the regenerating liver and in culture.

1992 • 151 citations

The Transcription Factor DBP Affects Circadian Sleep Consolidation and Rhythmic EEG Activity

2000 • 149 citations

CHOP-Dependent Stress-Inducible Expression of a Novel Form of Carbonic Anhydrase VI

1999 • 146 citations

The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue-specific expression, but have different target promoter preferences.

1996 • 145 citations

Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements.

1994 • 144 citations

Transcriptional Activity of CCAAT/Enhancer-binding Proteins Is Controlled by a Conserved Inhibitory Domain That Is a Target for Sumoylation

2002 • 143 citations

CCAAT/Enhancer-binding Protein-α Cooperates with p21 to Inhibit Cyclin-dependent Kinase-2 Activity and Induces Growth Arrest Independent of DNA Binding

2001 • 137 citations

LAP (NF-IL-6), a tissue-specific transcriptional activator, is an inhibitor of hepatoma cell proliferation.

1994 • 135 citations

Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach

2003 • 133 citations

Inhibition of cell proliferation by C/EBPα occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen

1995 • 133 citations

Ig/EBP (C/EBPγ) is a transdominant negative inhibitor of C/EBP family transcriptional activators

1995 • 132 citations

Re‐expression of C/EBPα induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells

1998 • 131 citations

The Ability of C/EBPβ but Not C/EBPα To Synergize with an Sp1 Protein Is Specified by the Leucine Zipper and Activation Domain

1997 • 130 citations

Isolation, characterization and chromosomal localization of the human GADD153 gene

1992 • 130 citations

Calcium ionophore A23187 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancer-binding protein (C/EBP)-related gene, gadd153. Ca2+ increases transcriptional activity and mRNA stability.

1992 • 129 citations

Glucocorticoids Stimulate p21 Gene Expression by Targeting Multiple Transcriptional Elements within a Steroid Responsive Region of the p21 Promoter in Rat Hepatoma Cells

1998 • 126 citations

Constitutive expression of hepatic cytochrome P450 genes

1996 • 126 citations

Phosphorylation of CCAAT-enhancer binding protein by protein kinase C attenuates site-selective DNA binding.

1992 • 124 citations

Developmental Expression of Cytochrome P450 Enzymes in Human Liver

1998 • 123 citations

Role of the CCAAT/Enhancer Binding Protein-α Transcription Factor in the Glucocorticoid Stimulation of p21 Gene Promoter Activity in Growth-arrested Rat Hepatoma Cells

1998 • 122 citations

The C/EBP family of transcription factors in the liver and other organs

1998 • 122 citations

C/EBPα: a critical regulator of genes governing integrative metabolic processes

1995 • 121 citations

Isolation and characterization of the hamster gadd153 gene. Activation of promoter activity by agents that damage DNA.

1990 • 120 citations

Hepatocellular carcinoma: From bedside to proteomics

2001 • 119 citations

Serum amyloid A gene expression under acute-phase conditions involves participation of inducible C/EBP-beta and C/EBP-delta and their activation by phosphorylation.

1994 • 118 citations

A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBP beta and an Sp1 factor.

1994 • 117 citations

Physical and Functional Association between GADD153 and CCAAT/Enhancer-binding Protein β during Cellular Stress

1996 • 113 citations

High level activity of the mouse CCAAT/enhancer binding protein (C/EBPα) gene promoter involves autoregulation and several ubiquitous transcription factors

1993 • 110 citations

C/EBPα Regulates Generation of C/EBPβ Isoforms through Activation of Specific Proteolytic Cleavage

1999 • 109 citations

C/EBPα Regulates Formation of S-Phase-Specific E2F-p107 Complexes in Livers of Newborn Mice

1999 • 108 citations

Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)‒ATF composite site to regulate Gadd153 expression during the stress response

1999 • 106 citations

Purification and characterization of nucleolin and its identification as a transcription repressor.

1994 • 105 citations

Tumor Necrosis Factor α Promotes Nuclear Localization of Cytokine-inducible CCAAT/Enhancer Binding Protein Isoforms in Hepatocytes

1996 • 104 citations

Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha

2001 • 104 citations

S Phase-Specific Proteolytic Cleavage Is Required To Activate Stable DNA Binding by the CDP/Cut Homeodomain Protein

2001 • 104 citations

Interleukin-6-induced Tethering of STAT3 to the LAP/C/EBPβ Promoter Suggests a New Mechanism of Transcriptional Regulation by STAT3

2001 • 103 citations

Cell-specific transcriptional control of the mouse DNA-binding protein mC/EBP.

1989 • 103 citations

DNA specificity enhanced by sequential binding of protein monomers

1999 • 102 citations

Intracellular Targeting of Proteins by Sumoylation

2001 • 102 citations

Growth Hormone Regulates Phosphorylation and Function of CCAAT/Enhancer-binding Protein β by Modulating Akt and Glycogen Synthase Kinase-3

2001 • 101 citations

Contribution of cyclooxygenase‐2 to liver regeneration after partial hepatectomy

2001 • 101 citations

Molecular Cloning, Sequence, and Expression Patterns of the Human Gene Encoding CCAAT/Enhancer Binding Protein α (C/EBPα)

1995 • 101 citations

The Factor VIII acute phase response requires the participation of NFkappaB and C/EBP.

2000 • 100 citations

Insulin Inhibits Hepatocellular Glucose Production by Utilizing Liver-enriched Transcriptional Inhibitory Protein to Disrupt the Association of CREB-binding Protein and RNA Polymerase II with the Phosphoenolpyruvate Carboxykinase Gene Promoter

2002 • 99 citations

Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis

2002 • 99 citations

The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences.

1995 • 99 citations

Calreticulin Interacts with C/EBPα and C/EBPβ mRNAs and Represses Translation of C/EBP Proteins

2002 • 94 citations

Coexistence of C/EBP alpha, beta, growth-induced proteins and DNA synthesis in hepatocytes during liver regeneration. Implications for maintenance of the differentiated state during liver growth.

1995 • 94 citations

The role of the transcriptional activator protein DBP in circadian liver gene expression

1992 • 93 citations

Cross-talk between transcription factors NF-κB and C/EBP in the transcriptional regulation of genes

1997 • 93 citations

Angiotensinogen Gene Polymorphism at −217 Affects Basal Promoter Activity and Is Associated with Hypertension in African-Americans

2002 • 90 citations

Chicken vitellogenin gene-binding protein, a leucine zipper transcription factor that binds to an important control element in the chicken vitellogenin II promoter, is related to rat DBP.

1991 • 89 citations

Concanavalin A-induced liver injury triggers hepatocyte proliferation.

1998 • 88 citations

ATF-2 and C/EBPα Can Form a Heterodimeric DNA Binding Complex in Vitro

1997 • 86 citations

Induction of GADD153, a CCAAT/enhancer-binding protein (C/EBP)-related gene, during the acute phase response in rats. Evidence for the involvement of C/EBPs in regulating its expression.

1994 • 85 citations

An "attenuator domain" is sandwiched by two distinct transactivation domains in the transcription factor C/EBP.

1991 • 85 citations

C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest

2002 • 84 citations

Regenerative changes in C/EBP alpha and C/EBP beta expression modulate binding to the C/EBP site in the c-fos promoter.

1994 • 84 citations

A conserved regulatory unit implicated in tissue-specific gene expression in Drosophila and man.

1992 • 84 citations

Multiple, functional DBP sites on the promoter of the cholesterol 7 alpha-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression.

1994 • 82 citations

Cytochrome P450 3A Expression in the Human Fetal Liver: Evidence that CYP3A5 Is Expressed in Only a Limited Number of Fetal Livers

2001 • 80 citations

The Transcription Factor CCAAT/Enhancer-binding Protein β Regulates Gluconeogenesis and Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription during Diabetes

1999 • 79 citations

At the Cutting Edge What is a cAMP response unit?

2000 • 79 citations

Translation start site multiplicity of the CCAAT/enhancer binding protein α mRNA is dictated by a small 5′ open reading frame

1994 • 79 citations

Urea-associated oxidative stress and Gadd153/CHOP induction

1999 • 78 citations

A Human Nuclear-Localized Chaperone that Regulates Dimerization, DNA Binding, and Transcriptional Activity of bZIP Proteins

1999 • 77 citations

Induction of the C/EBP Gene by Dexamethasone and Glucagon in Primary-Cultured Rat Hepatocytes

1996 • 70 citations

Hypoglycemia-associated Hyperammonemia Caused by Impaired Expression of Ornithine Cycle Enzyme Genes in C/EBPα Knockout Mice

1998 • 70 citations

Regulation of CCAAT/enhancer-binding protein-beta isoform synthesis by alternative translational initiation at multiple AUG start sites

2001 • 70 citations

Regenerating livers of old rats contain high levels of C/EBPalpha that correlate with altered expression of cell cycle associated proteins

1998 • 68 citations

Regulation of the homeodomain CCAAT displacement/ cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP

2000 • 68 citations

C/EBPα Is Critical for the Neonatal Acute-Phase Response to Inflammation

1998 • 67 citations

The Factor VIII Acute Phase Response Requires the Participation of NFκB and C/EBP

2000 • 66 citations

Identification of Heterogeneous Nuclear Ribonucleoprotein K (hnRNP K) as a Repressor of C/EBPβ-mediated Gene Activation

1998 • 66 citations

Identification and Characterization of a Nucleolar Phosphoprotein, Nopp140, as a Transcription Factor

1997 • 65 citations

Selective induction of CCAAT/enhancer binding protein isoforms occurs during rat liver development

1994 • 65 citations

Regulation of CCAAT/Enhancer-binding Protein (C/EBP) Activator Proteins by Heterodimerization with C/EBPγ (Ig/EBP)

2002 • 65 citations

CCAAT Displacement Protein Binds to and Negatively Regulates Human Papillomavirus Type 6 E6, E7, and E1 Promoters

1999 • 64 citations

Transcriptional Induction of the Alpha-1 Acid Glycoprotein (AGP) Gene by Synergistic Interaction of Two Alternative Activator Forms of AGP/Enhancer-Binding Protein (C/EBPβ) and NF-κB or Nopp140

1996 • 62 citations

Daily rhythms of glycogen synthetase and phosphorylase activities in rat liver: Influences of food and light

1976 • 60 citations

Molecular cloning, genetic mapping, and expression analysis of four zebrafish c/ebp genes

2001 • 59 citations

Glucocorticoid-Stimulated CCAAT/Enhancer-Binding Protein α Expression Is Required for Steroid-Induced G₁ Cell Cycle Arrest of Minimal-Deviation Rat Hepatoma Cells

1996 • 56 citations

A Novel Transcriptional Regulatory Region within the Core Promoter of the Hepatocyte Growth Factor Gene Is Responsible for Its Inducibility by Cytokines via the C/EBP Family of Transcription Factors

1997 • 56 citations

DNA-Binding Specificity of PAR and C/EBP Leucine Zipper Proteins: A Single Amino Acid Substitution in the C/EBP DNA-Binding Domain Confers PAR-Like Specificity to C/EBP

1996 • 56 citations

Autoregulation enables different pathways to control CCAAT/enhancer binding protein β (C/EBPβ) transcription

2001 • 55 citations

Phosphorylation of the CCAAT Displacement Protein (CDP)/Cux Transcription Factor by Cyclin A-Cdk1 Modulates Its DNA Binding Activity in G2

2001 • 55 citations

Translational induction of LIP during acute phase response leads to repression of C/EBP alpha mRNA

2000 • 53 citations

Bipartite determinants of DNA-binding specificity of plant basic leucine zipper proteins.

1999 • 53 citations

CCAAT/Enhancer-Binding Protein Gene Expression Is Mediated by APRF/STAT3

1997 • 52 citations

Diurnal variation in the activity of cholesterol 7α‐hydroxylase in the livers of fed and fasted rats

1972 • 51 citations

Adenovirus-mediated Transfer of CCAAT/Enhancer-binding Protein-α Identifies a Dominant Antiproliferative Role for This Isoform in Hepatocytes

1996 • 51 citations

p53 Represses CAAT Enhancer-binding Protein (C/EBP)-dependent Transcription of the Albumin Gene

1999 • 51 citations

Transcriptional regulation of the CYP2B1 and CYP2B2 genes by C/EBP-related proteins

1996 • 50 citations

Effect of thermal injury on the expression of transcription factors that regulate acute phase response genes: The response of C/EBPα, C/EBPβ, and C/EBPδ to thermal injury

1996 • 46 citations

Identification of a C/EBP-Rel Complex in Avian Lymphoid Cells

1994 • 45 citations

Distribution of labor among bZIP segments in the control of DNA affinity and specificity

1994 • 45 citations

Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors CEBP, DBP, and HNF1LFB-1> (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)

1992 • 45 citations

A Nucleoprotein Complex containing CCAAT/Enhancer-binding Protein β Interacts with an Insulin Response Sequence in the Insulin-like Growth Factor-binding Protein-1 Gene and Contributes to Insulin-regulated Gene Expression

2001 • 45 citations

Transcription Profiling Distinguishes Dose-Dependent Effects in the Livers of Rats Treated with Clofibrate

2003 • 44 citations

TheCYP2B1Proximal Promoter Contains a Functional C/EBP Regulatory Element

1996 • 44 citations

Mice lacking CCAAT/enhancer-binding protein-? show hyperproliferation of alveolar type II cells and increased surfactant protein mRNAs

2001 • 44 citations

Liver gene expression in rats in response to the peroxisome proliferator-activated receptor-α agonist ciprofibrate

2003 • 42 citations

CCAAT/Enhancer-Binding Protein-α Is a Component of the Growth Hormone-Regulated Network of Liver Transcription Factors*

2000 • 42 citations

Glucocorticoid Receptor-Dependent Inhibition of Cellular Proliferation in Dexamethasone-Resistant and Hypersensitive Rat Hepatoma Cell Variants

1988 • 42 citations

Role of the liver-enriched transcription factors C/EBPα and DBP in the expression of human CYP3A4 and CYP3A7

1997 • 41 citations

Matrix Induced Re-Differentiation of Cultured Rat Hepatocytes and Changes of CCAAT/Enhancer Binding Proteins

1997 • 41 citations

CCAAT/Enhancer-binding Proteins α and β Interact with the Silencer Element in the Promoter of Glutathione S-Transferase P Gene during Hepatocarcinogenesis

1995 • 41 citations

Induction of nuclear transcription factors, cytochrome P450 monooxygenases, and glutathione S-transferase alpha gene expression in Aroclor 1254-treated rat hepatocyte cultures11Abbreviations: Ah, aryl hydrocarbon; c/EBP, CCAAT/enhancer-binding protein; cDNA, complementary DNA CYP, cytochrome P450; EROD, ethoxyresorufin-O-deethylase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GSTA, glutathione S-transferase alpha; HNF, hepatic nuclear factor; RT–PCR, reverse transcription–polymerase chain …

2001 • 40 citations

Conserved Amino Acids within CCAAT Enhancer-binding Proteins (C/EBPα and β) Regulate Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression

2002 • 40 citations

HiNF-D (CDP-cut/CDC2/cyclin A/pRB-complex) influences the timing of IRF-2-dependent cell cycle activation of human histone H4 gene transcription at the G1/S phase transition

1998 • 39 citations

CCAAT/Enhancer-binding Protein β (C/EBPβ) and C/EBPδ Contribute to Growth Hormone-regulated Transcription of c-fos

1999 • 39 citations

Circadian clocks

1997 • 39 citations

Contribution of cholesterol 7α-hydroxylase to the regulation of lipoprotein metabolism

1999 • 37 citations

Development : genetics, epigenetics, and environmental regulation

1999 • 37 citations

Autoregulated Induction of the Acute-Phase Response Transcription Factor Gene,agp/ebp

1995 • 36 citations

Role of the Liver-Enriched Transcription Factor DBP in Expression of the Cytochrome P450 CYP2C6 Gene

1992 • 36 citations

Interleukin-6 and CAAT/Enhancer Binding Protein β-Deficient Mice Act as Tools to Dissect the IL-6 Signalling Pathway and IL-6 Regulation

1997 • 35 citations

Hormonal Regulation of the Phosphoenolpyruvate Carboxykinase Gene

2000 • 35 citations

Analysis of the Xenopus laevis CCAAT-enhancer binding protein alpha gene promoter demonstrates species-specific differences in the mechanisms for both auto-activation and regulation by Sp1

2001 • 31 citations

Hepatic expression of CCAAT/enhancer binding protein α: hormonal and metabolic regulation in rats

1997 • 31 citations

CCAAT/enhancer-binding protein-alpha-dependent transactivation of CYP2C12 in rat hepatocytes.

1995 • 31 citations

Chromosomal Localization and cDNA Cloning of the Human DBP and TEF Genes

1994 • 30 citations

Characterization of the Promoter Region of the Rat CCAAT/Enhancer-Binding Protein α Gene and Regulation by Thyroid Hormone in Rat Immortalized Brown Adipocytes¹

2000 • 30 citations

Role of IL-1β and corticosteroids in the regulation of the C/EBP-α, β and δ genes in vivo

1995 • 30 citations

Cloning of the cDNA encoding human C/EBPγ, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter

1995 • 30 citations

Diurnal variations in the activities of the glycogen metabolizing enzymes in mouse liver

1985 • 29 citations

Transactivation of LAP/NF-IL6 Is Mediated by an Acidic Domain in the N-terminal Part of the Protein

1995 • 29 citations

The Human C/EBPδ (CRP3/CELF) Gene: Structure and Chromosomal Localization

1993 • 28 citations

CCAAT/Enhancer-Binding Protein δ Gene Expression Is Mediated by Autoregulation through Downstream Binding Sites

1998 • 28 citations

Transcription factors modulating angiotensinogen gene expression in hepatocytes

1994 • 28 citations

Diurnal Variation in Hepatic Expression of the Rat S14 Gene Is Synchronized by the Photoperiod*

1987 • 27 citations

Regulation by Thyroid Hormone and Retinoic Acid of the CCAAT/Enhancer Binding Protein α and β Genes during Liver Development

1997 • 26 citations

Dimerization and DNA Binding Facilitate aaa-Helix Formation of Max in Solution

1997 • 26 citations

A Role for CCAAT/Enhancer-binding Protein in Hepatic Expression of Thrombin-activable Fibrinolysis Inhibitor

2002 • 26 citations

Aroclor 1254 Modulates Gene Expression of Nuclear Transcription Factors: Implications for Albumin Gene Transcription and Protein Synthesis in Rat Hepatocyte Cultures

2002 • 25 citations

Induction of a subgroup of acute phase protein genes in mouse liver by hyperthermia

1998 • 25 citations

The Transcriptional Activation Pattern of Lipopolysaccharicle Binding Protein (LBP) Involving Transcription Factors AP-1 and C/EBPβ

1997 • 25 citations

Role of the liver-enriched transcription factor DBP in expression of the cytochrome P450 CYP2C6 gene.

1992 • 24 citations

The homeodomain transcription factor CDP/cut interacts with the cell cycle regulatory element of histone H4 genes packaged into nucleosomes.

1999 • 24 citations

The pathway regulating GADD153 induction in response to DNA damage is independent of protein kinase C and tyrosine kinases.

1994 • 24 citations

Transcription Profiling Distinguishes Dose-Dependent Effects in the Livers of Rats Treated with Clofibrate

2003 • 24 citations

Changes in expression of CCAAT/enhancer binding protein α (C/EBPα) and C/EBPβ in rat liver after partial hepatectomy but not after treatment with cyproterone acetate

1997 • 23 citations

CCAAT/enhancer binding protein ? (C/EBP?) is an important mediator of mouse C/EBP? protein isoform production

1999 • 22 citations

Functional Interaction of bZIP Proteins and the Large Subunit of Replication Factor C in Liver and Adipose Cells

2001 • 22 citations

Identification of a C/EBP-Rel complex in avian lymphoid cells.

1994 • 21 citations

Lower Activity of CCAAT/Enhancer-Binding Protein and Expression of Cyclin E, but Not Cyclin D1, Activating Protein-1 and p21WAF1, after Partial Hepatectomy in Obstructive Jaundice

2001 • 21 citations

The Nuclear Matrix Protein CDP Represses Hepatic Transcription of the Human Cholesterol-7α Hydroxylase Gene

2000 • 21 citations

EFFECTS OF PERTURBATIONS OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS ON THE ACUTE PHASE RESPONSE

1996 • 20 citations

Decreased expression of the CCAAT/enhancer binding protein α gene involved in hepatocyte proliferation in human hepatocellular carcinomas

2002 • 18 citations

Growth hormone induces CCAAT/enhancer binding protein α (C/EBPα) in cultured rat hepatocytes

2000 • 18 citations

Liver-Enriched Transcription Factors, HNF-1, HNF-3, and C/EBP, Are Major Contributors to the Strong Activity of the ChickenCYP2H1Promoter in Chick Embryo Hepatocytes

1997 • 17 citations

Nuclear export: DNA-binding domains find a surprising partner

2001 • 17 citations

Transcriptional Induction of theagp/ebp(c/ebpβ) Gene by Hepatocyte Growth Factor

1997 • 17 citations

Modulation of circadian expression of D-site binding protein by the schedule of parenteral nutrition in rat liver

1997 • 17 citations

Glucocorticoid receptor-dependent inhibition of cellular proliferation in dexamethasone-resistant and hypersensitive rat hepatoma cell variants.

1988 • 17 citations

Modulation of circadian expression of D-site binding protein by the schedule of parenteral nutrition in rat liver

1997 • 16 citations

IRE-ABP (Insulin Response Element-A Binding Protein), an SRY-Like Protein, Inhibits C/EBPα (CCAAT/Enhancer-Binding Proteinα )-Stimulated Expression of the Sex-Specific Cytochrome P450 2C12 Gene

1998 • 16 citations

Enhanced Binding of HLF/DBP Heterodimers Represents One Mechanism of PAR Protein Transactivation of the Factor VIII and Factor IX Genes

1999 • 16 citations

Identification of CCAAT Displacement Protein (CDP/cut) as a Locus-specific Repressor of Major Histocompatibility Complex Gene Expression in Human Tumor Cells

2001 • 16 citations

The DBP transcriptional activation domain is highly homologous to that of HLF and TEF and is not responsible for the tissue type-specific transcriptional activity of DBP

2001 • 16 citations

Diurnal variation in glycogen phosphorylase activity in rat liver. A quantitative histochemical study.

1987 • 15 citations

Fas-induced apoptosis in mouse hepatocytes is dependent on C/EBPβ

2001 • 14 citations

CCAAT/enhancer-binding protein-alpha-dependent transactivation of CYP2C12 in rat hepatocytes

1995 • 13 citations

D-site Binding Protein Transactivation Requires the Proline- and Acid-rich Domain and Involves the Coactivator p300

1999 • 12 citations

Circadian Timing in Animals

1999 • 10 citations

Genomic Structure of the Human D-Site Binding Protein (DBP) Gene

1996 • 9 citations

C/EBPα AND C/EBPβ ARE PERSISTENTLY ASSOCIATED WITH THE RAT LIVER NUCLEAR MATRIX THROUGHOUT DEVELOPMENT AND THE ACUTE PHASE RESPONSE

2000 • 9 citations

Characterization of the Promoter Region of the Rat CCAAT/Enhancer-Binding Protein Gene and Regulation by Thyroid Hormone in Rat Immortalized Brown Adipocytes

2000 • 8 citations

CCAAT/Enhancer-Binding Protein- Is a Component of the Growth Hormone-Regulated Network of Liver Transcription Factors

2000 • 7 citations

The adult enhancer factor-1, a Drosophila melanogaster transcriptional repressor, modulates the promoter activity of the rat class-I alcohol dehydrogenase-encoding gene

1994 • 6 citations

Gene Expression of CCAAT/Enhancer-Binding Protein .DELTA. Mediated by Autoregulation Is Repressed by Related Gene Family Proteins.

2000 • 6 citations

Regenerative changes in C/EBPα and C/EBPβ expression modulate binding to the C/EBP site in the c-fos promoter

1994 • 4 citations

The avian C/EBPγ gene encodes a highly conserved leucine zipper transcription factor

1997 • 4 citations

IRE-ABP (Insulin Response Element-A Binding Protein), an SRY-Like Protein, Inhibits C/EBP (CCAAT/Enhancer-Binding Protein )-Stimulated Expression of the Sex-Specific Cytochrome P450 2C12 Gene

1998 • 4 citations

Interference Mapping of Nuclear Protein Binding to the Acute Phase Response Element of the Mouse α1Acid Glycoprotein Gene

1999 • 3 citations

PPAR alpha Mediated Responses in the Rodent Liver An Holistic Biochemical View

2000 • 3 citations

Induction of GADD158, a CCAAT/enhancer-binding protein (CIEBP)-related gene, during the acute phase response in rats. Evidence for the involvement of C/EBPs in regulating its expression.

1995 • 2 citations

The DNA binding affinity of rat liver nucleoproteins to the α1‐acid glycoprotein gene

1996 • 2 citations