The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors.

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

1981 • 2,891 citations

A short amino acid sequence able to specify nuclear location

1984 • 2,529 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

THE MOLECULAR BIOLOGY OF THE HEPATITIS B VIRUSES

1987 • 1,046 citations

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

1989 • 692 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

STRUCTURE AND FUNCTION OF SIMIAN VIRUS 40 LARGE TUMOR ANTIGEN

1992 • 506 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

Woodchuck hepatitis virus X protein is required for viral infection in vivo

1994 • 443 citations

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

1994 • 418 citations

The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks

1993 • 372 citations

Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway

1993 • 371 citations

Trans-activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses.

1986 • 368 citations

trans-activation of viral enhancers by the hepatitis B virus X protein

1988 • 316 citations

Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma.

1993 • 307 citations

Transcriptional trans-activating function of hepatitis B virus

1987 • 280 citations

High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice

1994 • 277 citations

Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation.

1995 • 263 citations

Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation

1995 • 250 citations

Hepatitis B virus X protein interacts with a probable cellular DNA repair protein

1995 • 249 citations

Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors

1990 • 247 citations

Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA.

1990 • 236 citations

Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein.

1988 • 212 citations

Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication

1989 • 204 citations

Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C

1992 • 203 citations

Redistribution and differential extraction of soluble proteins in permeabilized cultured cells Implications for immunofluorescence microscopy

1992 • 202 citations

Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice

1990 • 196 citations

Hepatitis B virus transactivator protein X interacts with the TATA-binding protein.

1995 • 190 citations

The × Gene of Hepatitis B Virus Induced Growth Stimulation and Tumorigenic Transformation of Mouse NIH3T3 Cells

1989 • 169 citations

Antibodies to Peptides Detect New Hepatitis B Antigen: Serological Correlation with Hepatocellular Carcinoma

1985 • 169 citations

The HBV X-ORF encodes a transactivator: a potential factor in viral hepatocarcinogenesis.

1988 • 161 citations

Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases.

1993 • 160 citations

The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters.

1990 • 159 citations

Methods for identifying antigenic determinants and other interaction sites

1986 • 159 citations

The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB.

1995 • 157 citations

trans-Activation of viral enhancers including long terminal repeat of the human immunodeficiency virus by the hepatitis B virus X protein

1989 • 145 citations

Different localization of the product of the v-rel oncogene in chicken fibroblasts and spleen cells correlates with transformation by REV-T

1986 • 142 citations

Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor kappa B and induces nuclear translocation of transcription factor NF-kappa B proteins for transcriptional activation.

1994 • 142 citations

Expression of the hepatitis B virus X gene in mammalian cells.

1987 • 131 citations

Ras- and Raf-dependent activation of c-jun transcriptional activity by the hepatitis B virus transactivator pX.

1994 • 128 citations

Induction of the DNA-Binding Activity of c-Jun/c-Fos Heterodimers by the Hepatitis B Virus Transactivator pX

1994 • 127 citations

Activation of Protooncogene C-jun by the X Protein of Hepatitis B Virus

1993 • 123 citations

Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein.

1994 • 122 citations

Full-length and truncated versions of the hepatitis B virus (HBV) X protein (pX) transactivate the cMYC protooncogene at the transcriptional level

1991 • 120 citations

Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency.

1994 • 109 citations

Identification of three essential regions of hepatitis B virus X protein for trans-activation function.

1992 • 99 citations

The HBV HBX gene expressed in E. coli is recognised by sera from hepatitis patients.

1985 • 99 citations

The X protein of the hepatitis B virus acts as a transcription factor when targeted to its responsive element.

1990 • 94 citations

Phosphorylation and rapid turnover of hepatitis B virus X-protein expressed in HepG2 cells from a recombinant vaccinia virus.

1991 • 81 citations

Activation of class I major histocompatibility complex gene expression by hepatitis B virus

1990 • 78 citations

Alternate translation initiation on hepatitis B virus X mRNA produces multiple polypeptides that differentially transactivate class II and III promoters

1992 • 78 citations

Hepatitis B virus X protein transactivates the long terminal repeats of human immunodeficiency virus types 1 and 2

1990 • 77 citations

Hepatitis B virus polypeptide X: expression in Escherichia coli and identification of specific antibodies in sera from hepatitis B virus-infected humans

1986 • 75 citations

Hepatitis B X-gene expression in hepatocellular carcinoma

1992 • 70 citations

The hepatitis B virus (HBV) pX transactivates the c-fos promoter through multiple cis-acting elements.

1993 • 69 citations

Trans-activation of HLA-DR gene by hepatitis B virus X gene product.

1990 • 69 citations

Hepatitis B virus (HBV)-specific cytotoxic T-cell response in humans: production of target cells by stable expression of HBV-encoded proteins in immortalized human B-cell lines

1992 • 66 citations

Two-Codon Insertion Mutations of the HBx Define Two Separate Regions Necessary for Its Trans-activation Function

1993 • 58 citations

Interaction of hepatitis B virus X protein with a serine protease, tryptase TL2 as an inhibitor.

1994 • 52 citations

Transcriptional activation by simian virus 40 large T antigen: requirements for simple promoter structures containing either TATA or initiator elements with variable upstream factor binding sites

1993 • 47 citations

Detection of hepatitis B virus X product using an open reading frame Escherichia coli expression vector.

1986 • 44 citations

Synthesis of the X-protein of hepatitis B virus in vitro and detection of anti-X antibodies in human sera

1987 • 43 citations

Hepatitis B virus (HBV) X gene expression in human cells and anti-HBx antibodies detection in chronic HBV infection

1990 • 42 citations

Human T-Cell Leukemia Virus Type I Tax Associates with and Is Negatively Regulated by the NF-κB2 p100 Gene Product: Implications for Viral Latency

1994 • 40 citations

Secretion by mononuclear phagocytes of lysosomal hydrolases bearing ligands for the mannose-6-phosphate receptor system of fibroblasts: Evidence for a second mechanism of spontaneous secretion?

1982 • 36 citations

Detection of hepatitis B virus X gene protein and antibody in type B chronic liver disease

1989 • 35 citations

Expression of X protein and hepatitis B virus replication in chronic hepatitis

1991 • 33 citations

Mouse Monoclonal Antibody Directed against Hepatitis B Virus X Protein Synthesized in <i>Escherichia coli</i>: Detection of Reactive Antigen in Liver Cell Carcinoma and Chronic Hepatitis

1990 • 33 citations

Purification of hepatitis B virus gene X product synthesized in Escherichia coli and its detection in a human hepatoblastoma cell line producing hepatitis B virus

1987 • 26 citations

Novel short transcripts of hepatitis B virus X gene derived from intragenic promoter.

1994 • 26 citations

The Effects of SV40 Large T Antigen and p53 on Nuclear Transport Capacity in BALB/c 3T3 Cells

1994 • 22 citations

Chapter 12 Techniques for Localizing Contractile Proteins with Fluorescent Antibodies

1980 • 19 citations

Mutual functional antagonism of the simian virus 40 T antigen and the hepatitis B virus trans activator

1991 • 15 citations

Increased growth of permanent mouse fibroblasts in soft agar after transfection with hepatitis B virus DNA

1992 • 12 citations

Identification of an endosome-specific antigen

1991 • 3 citations