Hepatitis B Virus X Protein Interferes with Cellular DNA Repair

Basic Methods in Molecular Biology

1986 • 3,284 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line

1979 • 1,305 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

DNA EXCISION REPAIR

1996 • 1,127 citations

Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.

1987 • 1,098 citations

Mammalian DNA nucleotide excision repair reconstituted with purified protein components

1995 • 833 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

Woodchuck hepatitis virus X protein is required for viral infection in vivo

1994 • 443 citations

Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells.

1994 • 439 citations

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

1994 • 418 citations

The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks

1993 • 372 citations

Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway

1993 • 371 citations

The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors.

1995 • 311 citations

Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma.

1993 • 307 citations

Nucleotide excision repair II: from yeast to mammals

1993 • 304 citations

The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice

1997 • 286 citations

Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation.

1995 • 263 citations

Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation

1995 • 250 citations

Hepatitis B virus X protein interacts with a probable cellular DNA repair protein

1995 • 249 citations

Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA.

1990 • 236 citations

RELATIONSHIPS BETWEEN DNA REPAIR AND TRANSCRIPTION

1996 • 235 citations

Comparative analysis of binding of human damaged DNA-binding protein (XPE) and Escherichia coli damage recognition protein (UvrA) to the major ultraviolet photoproducts: T[c,s]T, T[t,s]T, T[6-4]T, and T[Dewar]T.

1993 • 208 citations

Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E.

1993 • 208 citations

Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice

1990 • 196 citations

Development and field-test validation of an assay for DNA repair in circulating human lymphocytes.

1991 • 194 citations

Hepatitis B virus transactivator protein X interacts with the TATA-binding protein.

1995 • 190 citations

Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virusX gene

1996 • 182 citations

Proteasome complex as a potential cellular target of hepatitis B virus X protein

1996 • 170 citations

The × Gene of Hepatitis B Virus Induced Growth Stimulation and Tumorigenic Transformation of Mouse NIH3T3 Cells

1989 • 169 citations

Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases.

1993 • 160 citations

Use of E. coli lacZ (β-Galactosidase) as a Reporter Gene

2003 • 142 citations

Ras- and Raf-dependent activation of c-jun transcriptional activity by the hepatitis B virus transactivator pX.

1994 • 128 citations

Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein.

1994 • 123 citations

XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation

1996 • 120 citations

Xeroderma pigmentosum group E binding factor recognizes a broad spectrum of DNA damage

1994 • 114 citations

Purification and characterization of a human protein that binds to damaged DNA

1993 • 112 citations

Interaction of the UV-damaged DNA-binding protein with hepatitis B virus X protein is conserved among mammalian hepadnaviruses and restricted to transactivation-proficient X-insertion mutants

1997 • 109 citations

Woodchuck hepatitis virus X protein is present in chronically infected woodchuck liver and woodchuck hepatocellular carcinomas which are permissive for viral replication

1996 • 105 citations

A 127 kDa component of a UV-damaged DNA-binding complex, which is defective in some xeroderma pigmentosum group E patients, is homologous to a slime mold protein

1993 • 105 citations

Identification of three essential regions of hepatitis B virus X protein for trans-activation function.

1992 • 99 citations

HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteasome alpha-subunit

1995 • 92 citations

The hepatitis B virus X gene: analysis of functional domain variation and gene phylogeny using multiple sequences

1995 • 90 citations

Biochemical heterogeneity in xeroderma pigmentosum complementation group E

1992 • 86 citations

UV damage-specific DNA-binding protein in xeroderma pigmentosum complementation group E

1991 • 84 citations

UV-induced DNA repair synthesis in cells of patients with different forms of xeroderma pigmentosum and of heterozygotes

1973 • 81 citations

DNA repair related to multiple skin cancers and drug use.

1994 • 71 citations

Trans-Activation of Cellular Genes By Hepatitis B Virus Proteins: A Possible Mechanism of Hepatocarcinogenesis

1996 • 64 citations

In vivo activity of the hepatitis B virus core promoter: tissue specificity and temporal regulation

1995 • 55 citations

Transgenic mice containing hepatitis B virus sequences are more susceptible to carcinogen-induced hepatocarcinogenesis

1990 • 54 citations

Interaction of hepatitis B virus X protein with a serine protease, tryptase TL2 as an inhibitor.

1994 • 52 citations

Hepatitis B Virus X-Protein Binds Damaged DNA and Sensitizes Liver Cells to Ultraviolet Irradiation

1997 • 51 citations

The X Protein of Hepatitis B Virus Has a ribo/deoxy ATPase Activity

1994 • 37 citations

Apolipoprotein B Gene Regulatory Factor-2 (BRF-2) Is Structurally and Immunologically Highly Related to Hepatitis B Virus X Associated Protein-1 (XAP-1)

1997 • 30 citations

Expression of mammary tumor virus proteins in preneoplastic outgrowth lines and mammary tumors of BALB/cV mice.

1984 • 28 citations

Is the DNA repair system involved in hepatitis-B-virus-mediated hepatocellular carcinogenesis?

1996 • 28 citations

Functional Analysis of Hepatitis B Virus Transactivator X: Implication of the Leucine Zipper-like Region and C-Terminal Seven Conserved Amino Acids in Functional Regions

1993 • 24 citations

Assessement of the relation between the initial viability and the attachment of freshly isolated rat hepatocytes used for the in vivo/in vitro DNA repair assay (UDS)

1993 • 17 citations

Transcriptional regulation of the apolipoprotein B100 gene: purification and characterization of trans-acting factor BRF-2.

1992 • 7 citations

Transcriptional Regulation of the Apolipoprotein B100 Gene: Purification and Characterization of trans -Acting Factor BRF-2

1992 • 1 citations