The Hepatitis B Virus X Protein Functionally Interacts with CREB-binding Protein/p300 in the Regulation of CREB-mediated Transcription

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

Transcriptional regulation by the phosphorylation-dependent factor CREB

2001 • 2,488 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

Transcription regulation and animal diversity

2003 • 1,279 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

p300/CBP proteins: HATs for transcriptional bridges and scaffolds

2001 • 1,046 citations

Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues

2005 • 977 citations

HIV-1 Genome Nuclear Import Is Mediated by a Central DNA Flap

2000 • 831 citations

Regulation of activity of the transcription factor GATA-1 by acetylation

1998 • 686 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication

1997 • 585 citations

EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts

1993 • 491 citations

The Enigmatic X Gene of Hepatitis B Virus

2004 • 486 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

Woodchuck hepatitis virus X protein is required for viral infection in vivo

1994 • 443 citations

Hepatitis B Virus Replication Is Regulated by the Acetylation Status of Hepatitis B Virus cccDNA-Bound H3 and H4 Histones

2006 • 436 citations

Calcium Signaling by HBx Protein in Hepatitis B Virus DNA Replication

2001 • 382 citations

Immune Pathogenesis of Hepatocellular Carcinoma

1998 • 375 citations

The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks

1993 • 372 citations

Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells

2003 • 362 citations

Adenovirus-5 E1A: paradox and paradigm

2002 • 301 citations

The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice

1997 • 286 citations

Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls.

1995 • 286 citations

Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation

1995 • 250 citations

Hepatitis B virus X protein interacts with a probable cellular DNA repair protein

1995 • 249 citations

Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA.

1990 • 236 citations

The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia

2005 • 230 citations

Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elements

1991 • 224 citations

The hepatitis B virus X gene induces p53-mediated programmed cell death

1997 • 199 citations

Distinct effects of cAMP and mitogenic signals on CREB-binding protein recruitment impart specificity to target gene activation via CREB

2001 • 189 citations

Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virusX gene

1996 • 182 citations

The Transcriptional Transactivation Function of HBx Protein Is Important for Its Augmentation Role in Hepatitis B Virus Replication

2005 • 180 citations

HBV induced carcinogenesis

2005 • 179 citations

Anchoring of CREB Binding Protein to the Human T-Cell Leukemia Virus Type 1 Promoter: a Molecular Mechanism of Tax Transactivation

1997 • 179 citations

p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro

1998 • 173 citations

RETRACTED: The E3 SUMO Ligase PIASy Is a Regulator of Cellular Senescence and Apoptosis

2006 • 167 citations

Coupling cAMP Signaling to Transcription in the Liver: Pivotal Role of CREB and CREM

2002 • 166 citations

Both Isoforms of the cAMP-dependent Protein Kinase Catalytic Subunit Can Activate Transcription of the Prolactin Gene

1989 • 162 citations

Enhanced Transgene Expression in Cord Blood CD34+-Derived Hematopoietic Cells, Including Developing T Cells and NOD/SCID Mouse Repopulating Cells, Following Transduction with Modified TRIP Lentiviral Vectors

2001 • 158 citations

A Pivotal Role of Cyclic AMP-Responsive Element Binding Protein in Tumor Progression

2004 • 158 citations

The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB.

1995 • 157 citations

Hepatitis B Virus X Protein Stimulates Viral Genome Replication via a DDB1-Dependent Pathway Distinct from That Leading to Cell Death

2005 • 156 citations

Transcriptional and post-transcriptional gene regulation of HTLV-1

2005 • 145 citations

Involvement of Crm1 in Hepatitis B Virus X Protein-Induced Aberrant Centriole Replication and Abnormal Mitotic Spindles

2003 • 140 citations

A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function.

1996 • 133 citations

CREB: the unindicted cancer co-conspirator

2005 • 130 citations

The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells.

1992 • 128 citations

Transcriptional Activation of Interleukin-8 by β-Catenin-Tcf4

2002 • 125 citations

Transcriptional repression of the human p53 gene by hepatitis B viral X protein

2000 • 119 citations

Src kinases involved in hepatitis B virus replication

1999 • 118 citations

Hepatitis B Virus X Protein Acts as a Tumor Promoter in Development of Diethylnitrosamine-Induced Preneoplastic Lesions

2001 • 117 citations

Interaction and Functional Cooperation between the LIM Protein FHL2, CBP/p300, and β-Catenin

2004 • 114 citations

Interaction of the UV-damaged DNA-binding protein with hepatitis B virus X protein is conserved among mammalian hepadnaviruses and restricted to transactivation-proficient X-insertion mutants

1997 • 109 citations

Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3)

2003 • 97 citations

Hepatitis B Virus HBx Protein Activation of Cyclin A–Cyclin-Dependent Kinase 2 Complexes and G ₁ Transit via a Src Kinase Pathway

2001 • 90 citations

The X Protein of Hepatitis B Virus Coactivates Potent Activation Domains

1995 • 88 citations

The Hepatitis B Virus X Protein Enhances the DNA Binding Potential and Transcription Efficacy of bZip Transcription Factors

1997 • 84 citations

Functional analysis of a liver-specific enhancer of the hepatitis B virus.

1991 • 69 citations

Hepatitis B Virus X Protein Induces Expression of Fas Ligand Gene through Enhancing Transcriptional Activity of Early Growth Response Factor

2004 • 56 citations

The carboxy‐terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia‐inducible factor‐1α

2004 • 56 citations

Promoter activity of the proliferating-cell nuclear antigen gene is associated with inducible CRE-binding proteins in interleukin 2-stimulated T lymphocytes.

1994 • 44 citations

PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts

2005 • 42 citations

Cell cycle dysregulation by HTLV-I: role of the TAX oncoprotein

2002 • 40 citations

Capped nonviral sequences at the 5' end of the mRNAs of rice hoja blanca virus RNA4

1995 • 40 citations

Different Regions of Hepatitis B Virus X Protein Are Required for Enhancement of bZip-Mediated Transactivation versus Transrepression

2000 • 38 citations

Impact of transforming viruses on cellular mutagenesis, genome stability, and cellular transformation

2005 • 37 citations

The Hepatitis B pX Protein Promotes Dimerization and DNA Binding of Cellular Basic Region/Leucine Zipper Proteins by Targeting the Conserved Basic Region

1999 • 29 citations

The Multifunctional Role of E1A in the Transcriptional Regulation of CREB/CBP-Dependent Target Genes

2003 • 28 citations

Hepatitis B Virus Protein pX Enhances the Monomer Assembly Pathway of bZIP·DNA Complexes

2001 • 11 citations

Hepatitis B Virus X Protein Activates Transcription by Bypassing CREB Phosphorylation, Not by Stabilizing bZIP−DNA Complexes

2000 • 9 citations