The Hepatitis B pX Protein Promotes Dimerization and DNA Binding of Cellular Basic Region/Leucine Zipper Proteins by Targeting the Conserved Basic Region

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

1989 • 1,046 citations

THE MOLECULAR BIOLOGY OF THE HEPATITIS B VIRUSES

1987 • 1,046 citations

The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted α Helices: Crystal structure of the protein-DNA complex

1992 • 964 citations

Evidence That the Leucine Zipper Is a Coiled Coil

1989 • 869 citations

Transcription activation by the adenovirus E1a protein

1989 • 667 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

Woodchuck hepatitis virus X protein is required for viral infection in vivo

1994 • 443 citations

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

1994 • 418 citations

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes.

1990 • 401 citations

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein

1990 • 391 citations

Sequence Requirements for Coiled-Coils: Analysis with λ Repressor-GCN4 Leucine Zipper Fusions

1990 • 379 citations

Folding transition in the DMA-binding domain of GCN4 on specific binding to DNA

1990 • 378 citations

The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks

1993 • 372 citations

Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway

1993 • 371 citations

Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: prediction and rational design.

1993 • 335 citations

Sequence-Specific DNA Binding by a Short Peptide Dimer

1990 • 318 citations

trans-activation of viral enhancers by the hepatitis B virus X protein

1988 • 316 citations

HTLV-I Tax Protein Stimulation of DNA Binding of bZIP Proteins by Enhancing Dimerization

1993 • 312 citations

The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors.

1995 • 311 citations

Design of DNA-Binding Peptides Based on the Leucine Zipper Motif

1990 • 296 citations

Functional domains of adenovirus type 5 E1a proteins

1987 • 283 citations

Release of Proteins and Peptides from Fusion Proteins Using a Recombinant Plant Virus Proteinase

1994 • 282 citations

Transcriptional trans-activating function of hepatitis B virus

1987 • 280 citations

High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice

1994 • 277 citations

Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors

1990 • 247 citations

Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA.

1990 • 236 citations

Activation of Src Family Kinases by Hepatitis B Virus HBx Protein and Coupled Signaling to Ras

1997 • 228 citations

The zta transactivator involved in induction of lytic cycle gene expression in Epstein-Barr virus-infected lymphocytes binds to both AP-1 and ZRE sites in target promoter and enhancer regions

1990 • 205 citations

Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C

1992 • 203 citations

The Epstein-Barr virus Zta transactivator: a member of the bZIP family with unique DNA-binding specificity and a dimerization domain that lacks the characteristic heptad leucine zipper motif

1990 • 199 citations

MOLECULAR EVENTS IN THE PATHOGENESIS OF HEPADNAVIRUS-ASSOCIATED HEPATOCELLULAR CARCINOMA

1994 • 176 citations

The × Gene of Hepatitis B Virus Induced Growth Stimulation and Tumorigenic Transformation of Mouse NIH3T3 Cells

1989 • 169 citations

The HBV X-ORF encodes a transactivator: a potential factor in viral hepatocarcinogenesis.

1988 • 161 citations

Transactivation by the human T-cell leukemia virus Tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2) ATF-2 response and cAMP element-binding protein (CREB).

1993 • 161 citations

Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases.

1993 • 160 citations

The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters.

1990 • 159 citations

The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB.

1995 • 157 citations

Mechanism of DNA-binding enhancement by the human T-cell leukaemia virus transactivator Tax

1995 • 150 citations

Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins

1992 • 135 citations

Recognition of bZIP proteins by the human T-cell leukaemia virus transactivator Tax

1995 • 131 citations

Ras- and Raf-dependent activation of c-jun transcriptional activity by the hepatitis B virus transactivator pX.

1994 • 128 citations

Induction of the DNA-Binding Activity of c-Jun/c-Fos Heterodimers by the Hepatitis B Virus Transactivator pX

1994 • 127 citations

Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein.

1994 • 122 citations

The hepatitis B virus-encoded transcriptional trans-activator hbx appears to be a novel protein serine/threonine kinase

1990 • 121 citations

Pleiotropic effect of the human T-cell leukemia virus Tax protein on the DNA binding activity of eukaryotic transcription factors.

1993 • 121 citations

Hepatitis B virus X gene activates kappa B-like enhancer sequences in the long terminal repeat of human immunodeficiency virus 1.

1989 • 116 citations

Transcriptional factor C/EBP binds to and transactivates the enhancer element II of the hepatitis B virus

1991 • 115 citations

Identification of three essential regions of hepatitis B virus X protein for trans-activation function.

1992 • 99 citations

Hepatitis B virus transcriptional activators: mechanisms and possible role in oncogenesis

1996 • 98 citations

The X protein of the hepatitis B virus acts as a transcription factor when targeted to its responsive element.

1990 • 94 citations

The hepatitis B virus X gene: analysis of functional domain variation and gene phylogeny using multiple sequences

1995 • 90 citations

The Hepatitis B Virus X Protein Enhances the DNA Binding Potential and Transcription Efficacy of bZip Transcription Factors

1997 • 84 citations

Activation of class I major histocompatibility complex gene expression by hepatitis B virus

1990 • 78 citations

Adaptability at the protein-DNA interface is an important aspect of sequence recognition by bZIP proteins.

1993 • 76 citations

Identification of an amino acid–base contact in the GCN4–DNA complex by bromouracil-mediated photocrosslinking

1992 • 76 citations

The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein

1995 • 74 citations

HTLV-1 tax: regulation of gene expression and disease

1993 • 73 citations

Direct interaction of CREB protein with 21 bp Tax-response elements of HTLV-ILTR.

1992 • 69 citations

Trans-activation of HLA-DR gene by hepatitis B virus X gene product.

1990 • 69 citations

The identification of hepatitis B virus X gene responsive elements reveals functional similarity of X and HTLV-I tax.

1990 • 65 citations

Interaction of hepatitis B virus X protein with a serine protease, tryptase TL2 as an inhibitor.

1994 • 52 citations

Structural determinants outside of the leucine zipper influence the interactions of CREB and ATF-2: interaction of CREB with ATF-2 blocks E1a-ATF-2 complex formation.

1993 • 47 citations

Mechanisms of human T-cell leukemia virus-induced leukemogenesis

1992 • 45 citations

HEPADNAVIRUSES AND HEPATOCELLULAR CARCINOMA

1991 • 45 citations

Up-regulation of intercellular adhesion molecule 1 transcription by hepatitis B virus X protein.

1992 • 45 citations

HTLV-I tax is a zinc-binding protein: Role of zinc in tax structure and function

1992 • 38 citations

The X Protein of Hepatitis B Virus Has a ribo/deoxy ATPase Activity

1994 • 37 citations

Transactivating function and expression of the x gene of hepatitis B virus

1995 • 28 citations

Sequence Requirements of ATF2 and CREB Binding to the Human T-Cell Leukemia Virus Type 1 LTR R Region

1996 • 14 citations

Mechanism of DNA Binding Enhancement by Hepatitis B Virus Protein pX

1997 • 13 citations

Activation of the HTLV-I Long Terminal Repeat by the Hepatitis B Virus X Protein

1996 • 6 citations