Turnover of Hepatitis B Virus X Protein Is Regulated by Damaged DNA-Binding Complex

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

1981 • 2,891 citations

Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*

1997 • 1,678 citations

SCF and Cullin/RING H2-Based Ubiquitin Ligases

1999 • 1,249 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

Management of hepatitis B: 2000—Summary of a workshop

2001 • 789 citations

ROC1, a Homolog of APC11, Represents a Family of Cullin Partners with an Associated Ubiquitin Ligase Activity

1999 • 457 citations

Substrate Targeting in the Ubiquitin System

1999 • 447 citations

The hsp90-based Chaperone System: Involvement in Signal Transduction from a Variety of Hormone and Growth Factor Receptors

1998 • 444 citations

Woodchuck hepatitis virus X protein is required for viral infection in vivo

1994 • 443 citations

Xeroderma Pigmentosum Group E Cells Lack a Nuclear Factor That Binds to Damaged DNA

1988 • 417 citations

The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks

1993 • 372 citations

Xeroderma Pigmentosum p48 Gene Enhances Global Genomic Repair and Suppresses UV-Induced Mutagenesis

2000 • 337 citations

Hepatitis B virus X protein: a multifunctional viral regulator

2001 • 323 citations

Hepatitis B Virus X Protein Is both a Substrate and a Potential Inhibitor of the Proteasome Complex

1999 • 227 citations

Hepatitis B virus X‐gene product: A promiscuous transcriptional activator

1992 • 208 citations

Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E.

1993 • 208 citations

Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication

1989 • 204 citations

Putative role of hepatitis B virus X protein in hepatocarcinogenesis: Effects on apoptosis, DNA repair, mitogen‐activated protein kinase and JAK/STAT pathways

2000 • 196 citations

The Xeroderma Pigmentosum Group E Gene Product DDB2 Is a Specific Target of Cullin 4A in Mammalian Cells

2001 • 161 citations

Cullin 4A Associates with the UV-damaged DNA-binding Protein DDB

1999 • 157 citations

Chromosomal Localization and cDNA Cloning of the Genes (DDB1 and DDB2) for the p127 and p48 Subunits of a Human Damage-Specific DNA Binding Protein

1995 • 157 citations

p48 Activates a UV-Damaged-DNA Binding Factor and Is Defective in Xeroderma Pigmentosum Group E Cells That Lack Binding Activity

1998 • 156 citations

X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis

2001 • 154 citations

Mutations Specific to the Xeroderma Pigmentosum Group E Ddb− Phenotype

1996 • 151 citations

Hepatitis B virus replication‐an update

1996 • 148 citations

Human Damage-specific DNA-binding Protein p48

2000 • 136 citations

The V Protein of the Paramyxovirus SV5 Interacts with Damage-Specific DNA Binding Protein

1998 • 134 citations

The Corepressor mSin3a Interacts with the Proline-Rich Domain of p53 and Protects p53 from Proteasome-Mediated Degradation

2001 • 130 citations

Interaction of the UV-damaged DNA-binding protein with hepatitis B virus X protein is conserved among mammalian hepadnaviruses and restricted to transactivation-proficient X-insertion mutants

1997 • 109 citations

Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome

1998 • 107 citations

More Than One Way to Skin a Catenin

2001 • 103 citations

The Naturally Occurring Mutants of DDB Are Impaired in Stimulating Nuclear Import of the p125 Subunit and E2F1-Activated Transcription

1999 • 100 citations

DDB, a Putative DNA Repair Protein, Can Function as a Transcriptional Partner of E2F1

1998 • 94 citations

HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteasome alpha-subunit

1995 • 92 citations

Interaction of the Hepatitis B Virus X Protein with the Crm1-dependent Nuclear Export Pathway

2001 • 89 citations

Phosphorylation and rapid turnover of hepatitis B virus X-protein expressed in HepG2 cells from a recombinant vaccinia virus.

1991 • 81 citations

Nuclear Transport of Human DDB Protein Induced by Ultraviolet Light

2000 • 80 citations

The proapoptotic effect of hepatitis B virus HBx protein correlates with its transactivation activity in stably transfected cell lines

1999 • 80 citations

Correct binding of viral X protein to UVDDB-p127 cellular protein is critical for efficient infection by hepatitis B viruses

2000 • 70 citations

Purification of an ultraviolet-inducible, damage-specific DNA-binding protein from primate cells.

1991 • 68 citations

Use of the polymerase chain reaction for the sensitive detection of St. Louis encephalitis viral RNA

1992 • 63 citations

UVDDB p127-binding modulates activities and intracellular distribution of Hepatitis B virus X protein

2000 • 52 citations

The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p

2001 • 49 citations

Hepatitis B Virus X Protein Interferes with Cell Viability through Interaction with the p127-kDa UV-Damaged DNA-Binding Protein

2001 • 45 citations

Metabolic Labeling of Woodchuck Hepatitis B Virus X Protein in Naturally Infected Hepatocytes Reveals a Bimodal Half-Life and Association with the Nuclear Framework

1998 • 44 citations

DDB2 Induces Nuclear Accumulation of the Hepatitis B Virus X Protein Independently of Binding to DDB1

2001 • 43 citations

Studies of the murine DDB1 and DDB2 genes

2000 • 30 citations