The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB.

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.

1985 • 3,185 citations

The hepatitis B virus

1985 • 1,219 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

A gene activated by growth factors is related to the oncogene v-jun.

1988 • 771 citations

Induction of proto-oncogene JUN/AP-1 by serum and TPA

1988 • 689 citations

CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription

1991 • 655 citations

Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts

1988 • 578 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway

1993 • 371 citations

trans-activation of viral enhancers by the hepatitis B virus X protein

1988 • 316 citations

HTLV-I Tax Protein Stimulation of DNA Binding of bZIP Proteins by Enhancing Dimerization

1993 • 312 citations

Transcriptional trans-activating function of hepatitis B virus

1987 • 280 citations

A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression.

1994 • 278 citations

Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors

1990 • 247 citations

Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly.

1990 • 245 citations

Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein.

1988 • 212 citations

Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication

1989 • 204 citations

Altered protein conformation on DNA binding by Fos and Jun

1990 • 193 citations

Antibodies to Peptides Detect New Hepatitis B Antigen: Serological Correlation with Hepatocellular Carcinoma

1985 • 169 citations

Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases.

1993 • 160 citations

trans-Activation of viral enhancers including long terminal repeat of the human immunodeficiency virus by the hepatitis B virus X protein

1989 • 145 citations

Hepatitis B virus X gene can transactivate heterologous viral sequences.

1989 • 137 citations

Induction of the DNA-Binding Activity of c-Jun/c-Fos Heterodimers by the Hepatitis B Virus Transactivator pX

1994 • 127 citations

The hepatitis B virus-encoded transcriptional trans-activator hbx appears to be a novel protein serine/threonine kinase

1990 • 121 citations

Hepatitis B virus X gene activates kappa B-like enhancer sequences in the long terminal repeat of human immunodeficiency virus 1.

1989 • 116 citations

Cellular factors that interact with the hepatitis B virus enhancer.

1989 • 108 citations

The X protein of the hepatitis B virus acts as a transcription factor when targeted to its responsive element.

1990 • 94 citations

Three sequence-specific DNA-protein complexes are formed with the same promoter element essential for expression of the rat somatostatin gene.

1988 • 67 citations

cAMP-dependent protein kinase, but not the cGMP-dependent enzyme, rapidly phosphorylates Δ-CREB, and a synthetic Δ-CREB peptide

1992 • 47 citations

In vitro transcription directed from the somatostatin promoter is dependent upon a purified 43-kDa DNA-binding protein.

1989 • 45 citations

Cellular Factors That Interact with the Hepatitis B Virus Enhancer

1989 • 43 citations

Hepatitis B virus X protein produced in Escherichia coli is biologically functional

1990 • 31 citations

Three Sequence-Specific DNA-Protein Complexes Are Formed with the Same Promoter Element Essential for Expression of the Rat Somatostatin Gene

1988 • 23 citations

Binding Constant Determination Studies Utilizing Recombinant ΔCREB Protein

1993 • 21 citations

Bacterial expression and characterization of the CREB bZip module: Circular dichroism and 2D ¹H‐NMR studies

1993 • 21 citations

Involvement of lysine residues 289 and 291 of the cAMP-responsive element-binding protein in the recognition of the cAMP-responsive element.

1991 • 9 citations