The cysteine residues of the hepatitis B virus onco-protein HBx are not required for its interaction with RNA or with human p53

p53 Mutations in Human Cancers

1991 • 8,133 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Metal chelate affinity chromatography, a new approach to protein fractionation

1975 • 2,050 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli

1979 • 992 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Hepatitis B Virus

1991 • 860 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

Woodchuck hepatitis virus X protein is required for viral infection in vivo

1994 • 443 citations

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1995 • 409 citations

The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks

1993 • 372 citations

Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis

1997 • 322 citations

Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma.

1993 • 307 citations

High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice

1994 • 277 citations

Cloning and Characterization of a Novel Hepatitis B Virus x Binding Protein That Inhibits Viral Replication

1998 • 220 citations

Proteasome complex as a potential cellular target of hepatitis B virus X protein

1996 • 170 citations

The × Gene of Hepatitis B Virus Induced Growth Stimulation and Tumorigenic Transformation of Mouse NIH3T3 Cells

1989 • 169 citations

Intracellular localization of the hepatitis B virus HBx protein

2001 • 164 citations

Hepatitis B Virus X Protein: Structure, Function and Biology

1999 • 163 citations

Hepatitis B Virus X Protein Is a Transcriptional Modulator That Communicates with Transcription Factor IIB and the RNA Polymerase II Subunit 5

1997 • 160 citations

Hepatitis B Virus pX Targets TFIIB in Transcription Coactivation

1998 • 145 citations

A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function.

1996 • 133 citations

XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation

1996 • 120 citations

Interaction of the UV-damaged DNA-binding protein with hepatitis B virus X protein is conserved among mammalian hepadnaviruses and restricted to transactivation-proficient X-insertion mutants

1997 • 109 citations

Hepatitis B virus transcriptional activators: mechanisms and possible role in oncogenesis

1996 • 98 citations

Immobilization and affinity purification of recombinant proteins using histidine peptide fusions

1989 • 93 citations

HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteasome alpha-subunit

1995 • 92 citations

Regulation of RNA Polymerase I-Dependent Promoters by the Hepatitis B Virus X Protein via Activated Ras and TATA-Binding Protein

1998 • 85 citations

The Hepatitis B Virus X Protein Enhances the DNA Binding Potential and Transcription Efficacy of bZip Transcription Factors

1997 • 84 citations

Regulation of hepatitis B virus gene expression

1993 • 74 citations

Retroviral expression of the hepatitis B virus x gene promotes liver cell susceptibility to carcinogen-induced site specific mutagenesis

2000 • 65 citations

Identification and Characterization of Proteins That Selectively Interact with Isoforms of the mRNA Binding Protein AUF1 (hnRNP D)

2003 • 59 citations

Dual effects of hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53

2002 • 54 citations

Pro-apoptotic effect of the hepatitis B virus X gene

1998 • 52 citations

Expression of an Active Na,K-ATPase with an α-Subunit Lacking All Twenty-three Native Cysteine Residues

2000 • 39 citations

Apoptosis and apoptosis related proteins in chronic viral liver disease.

2002 • 39 citations

TP53 tumour suppressor gene: clues to molecular carcinogenesis and cancer therapy.

1996 • 38 citations

The Hepatitis B Virus Transactivator Protein, HBx, Interacts with Single-stranded DNA (ssDNA)

1996 • 38 citations

Disruption of the function of tumor-suppressor gene p53 by the hepatitis B virus X protein and hepatocarcinogenesis

1995 • 36 citations

Dissociation of DDB1-binding and transactivation properties of the hepatitis B virus X protein

2000 • 32 citations

Characteristics of the X gene of hepatitis B virus

1988 • 28 citations

Transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat by hepatitis B virus X-protein requires de novo protein synthesis

1990 • 27 citations

Transcriptional activation of the promoter of human cytomegalovirus immediate early gene (CMV-IE) by the hepatitis B viral X protein (HBx) through the NF-κB site

2002 • 18 citations

Expression of deletion mutants of the hepatitis B virus protein HBx in E. coli and characterization of their RNA binding activities

2001 • 16 citations

Partial characterization of the woodchuck tumor suppressor, p53, and its interaction with woodchuck hepatitis virus X antigen in hepatocarcinogenesis

1997 • 15 citations

Hepatitis B Virus Protein pX Enhances the Monomer Assembly Pathway of bZIP·DNA Complexes

2001 • 11 citations