Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity

Functional analysis

1973 • 14,327 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

Interleukin-10

1993 • 1,820 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Origin, maturation and antigen presenting function of dendritic cells

1997 • 1,375 citations

The immune system evolved to discriminate infectious nonself from noninfectious self

1992 • 1,324 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures

1997 • 860 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

1995 • 699 citations

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

1996 • 676 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells.

1997 • 615 citations

T cells and eosinophils in the pathogenesis of asthma

1992 • 585 citations

Effect of interleukin‐10 on dendritic cell maturation and function

1997 • 571 citations

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

1989 • 542 citations

Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.

1993 • 526 citations

Inhibition of Experimental Drug Allergy by Prior Feeding of the Sensitizing Agent

1946 • 510 citations

CD34+ Hematopoietic Progenitors From Human Cord Blood Differentiate Along Two Independent Dendritic Cell Pathways in Response to Granulocyte-Macrophage Colony-Stimulating Factor Plus Tumor Necrosis Factor α: II. Functional Analysis

1997 • 442 citations

The Cytokine Profile Expressed by Human Dendritic Cells Is Dependent on Cell Subtype and Mode of Activation

1998 • 436 citations

Dendritic Cells as Adjuvants for Immune-mediated Resistance to Tumors

1997 • 432 citations

Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces.

1994 • 395 citations

Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways.

1994 • 354 citations

Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function.

1990 • 349 citations

Dendritic cells and macrophages are required for Th1 development of CD4⁺ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-_γ production is IFN-_γ-dependent

1993 • 346 citations

Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction.

1980 • 329 citations

The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production.

1993 • 317 citations

Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways.

1991 • 316 citations

Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.

1992 • 306 citations

Human Dendritic Cells Require Exogenous Interleukin-12–Inducing Factors to Direct the Development of Naive T-Helper Cells Toward the Th1 Phenotype

1997 • 302 citations

Interleukin-10 Down-Regulates MHC Class II αβ Peptide Complexes at the Plasma Membrane of Monocytes by Affecting Arrival and Recycling

1997 • 302 citations

MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations.

1988 • 285 citations

The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.

1992 • 273 citations

Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro.

1989 • 260 citations

Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production.

1993 • 251 citations

Inhibition of specific IgE responses in mice by pre-exposure to inhaled antigen.

1981 • 229 citations

Endotoxin-mediated dendritic cell release from the intestine. Characterization of released dendritic cells and TNF dependence.

1995 • 226 citations

Immunohistochemical Characterization of the Cellular Infiltration in Asthmatic Bronchi

1992 • 224 citations

The role of interleukin 12 in the immune response, disease and therapy

1994 • 221 citations

Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo.

1992 • 215 citations

Interleukin-10 prevents dendritic cell accumulation and vaccination with granulocyte-macrophage colony-stimulating factor gene-modified tumor cells.

1997 • 200 citations

Ia‐positive dendritic cells form a tightly meshed network within the human airway epithelium

1989 • 188 citations

TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1‐dependent autoimmune disease

1993 • 182 citations

In vitro evidence that Langerhans cells can adopt two functionally distinct forms capable of antigen presentation to T lymphocytes.

1989 • 177 citations

Role of costimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86.

1997 • 174 citations

Interleukin‐12 induces interferon‐γ‐dependent switching of IgG alloantibody subclass

1996 • 160 citations

The Biological Reactions of the Vegetable Proteins I. Anaphylaxis

1911 • 158 citations

Development of long term tolerance versus sensitisation to environmental allergens during the perinatal period

1997 • 147 citations

Immunoprophylaxis of atopy: light at the end of the tunnel?

1994 • 140 citations

Regulation of house dust mite responses by intranasally administered peptide: transient activation of CD4⁺ T cells precedes the development of tolerance in vivo

1996 • 137 citations

Characterization of murine lung dendritic cells: similarities to Langerhans cells and thymic dendritic cells.

1990 • 134 citations

Mechanisms of mouse spleen dendritic cell function in the generation of influenza-specific, cytolytic T lymphocytes.

1992 • 128 citations

The rat mixed lymphocyte reaction: roles of a dendritic cell in intestinal lymph and T-cell subsets defined by monoclonal antibodies.

1981 • 123 citations

Induction of IgE-secreting cells and IgE isotype-specific suppressor T cells in the respiratory lymph nodes of rats in response to antigen inhalation

1985 • 109 citations

Subclass restriction of murine antibodies. III. Antigens that stimulate IgG3 in mice stimulate IgG2c in rats.

1980 • 100 citations

Interferon‐γ and interleukin‐10 inhibit antigen presentation by Langerhans cells for T helper type 1 cells by suppressing their CD80 (B7‐1) expression

1996 • 96 citations

Molecular cloning and characterization of murine IL-12 genes.

1996 • 93 citations

Mononuclear Cells in Human Lung Parenchyma: Characterization of a Potent Accessory Cell Not Obtained by Bronchoalveolar Lavage

1987 • 87 citations

Inflammatory infiltration of the upper airway epithelium during Sendai virus infection: involvement of epithelial dendritic cells

1997 • 86 citations

Activation of CD4+ T cells in the presence of a nondepleting monoclonal antibody to CD4 induces a Th2-type response in vitro.

1995 • 78 citations

Endocytosis by antigen presenting cells: dendritic cells are as endocytically active as other antigen presenting cells.

1992 • 74 citations

Induction of IgE-isotype specific tolerance by passive antigenic stimulation of the respiratory mucosa.

1983 • 69 citations

Immunoglobulin isotype regulation by antigen‐presenting cells in vivo

1994 • 57 citations

Subclass restriction of murine antibodies

1982 • 56 citations

Decreased anti‐donor major histocompatibility complex class I and increased class II alloantibody response in allograft tolerance in adult rats

1994 • 43 citations

Deleted Work

1955 • 0 citations