Salmonella-Induced Apoptosis of Infected Macrophages Results in Presentation of a Bacteria-Encoded Antigen after Uptake by Bystander Dendritic Cells

Dendritic cells and the control of immunity

1998 • 14,345 citations

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

Shigella flexneri induces apoptosis in infected macrophages

1992 • 1,130 citations

Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent.

1986 • 1,116 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures

1997 • 860 citations

Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches.

1994 • 859 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

TheSalmonellainvasin SipB induces macrophage apoptosis by binding to caspase-1

1999 • 748 citations

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.

1994 • 681 citations

Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells

1998 • 649 citations

Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

1993 • 625 citations

Salmonella typhimurium invasion induces apoptosis in infected macrophages.

1996 • 601 citations

Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production

1998 • 573 citations

Epithelial M Cells: Gateways for Mucosal Infection and Immunization

1996 • 536 citations

Murine Salmonellosis Studied by Confocal Microscopy: Salmonella typhimurium Resides Intracellularly Inside Macrophages and Exerts a Cytotoxic Effect on Phagocytes In Vivo

1997 • 489 citations

The ability of Salmonella to enter mammalian cells is affected by bacterial growth state.

1990 • 467 citations

ANTIGEN SAMPLING ACROSS EPITHELIAL BARRIERS AND INDUCTION OF MUCOSAL IMMUNE RESPONSES

1996 • 462 citations

Yersiniasignals macrophages to undergo apoptosis and YopJ is necessary for this cell death

1997 • 409 citations

Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB

1998 • 407 citations

A bacterial invasin induces macrophage apoptosis by binding directly to ICE.

1996 • 405 citations

Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages

1990 • 399 citations

SALMONELLOSIS: Host Immune Responses and Bacterial Virulence Determinants¹

1996 • 385 citations

Salmonella spp. are cytotoxic for cultured macrophages

1996 • 379 citations

HOW SALMONELLA SURVIVE AGAINST THE ODDS

1995 • 360 citations

Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch.

1996 • 360 citations

Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function.

1998 • 353 citations

Immunogenicity of Apoptotic Cells In Vivo: Role of Antigen Load, Antigen-Presenting Cells, and Cytokines

1999 • 295 citations

Cutting Edge: Bystander Apoptosis Triggers Dendritic Cell Maturation and Antigen-Presenting Function

1998 • 295 citations

The yopJ locus is required for Yersinia‐mediated inhibition of NF‐κB activation and cytokine expression: YopJ contains a eukaryotic SH2‐like domain that is essential for its repressive activity

1998 • 284 citations

Yersinia-induced Apoptosis In Vivo Aids in the Establishment of a Systemic Infection of Mice

1998 • 242 citations

Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II presentation to T cells.

1997 • 223 citations

Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri.

1994 • 209 citations

The invasion-associated type-III protein secretion system inSalmonella – a review

1997 • 201 citations

Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases

1999 • 192 citations

In vivo apoptosis in Shigella flexneri infections

1996 • 173 citations

Studying M cells and their role in infection

1998 • 127 citations

Functional significance of the regulation of macrophage Ia expression

1984 • 101 citations

Multimeric α-Lactalbumin from Human Milk Induces Apoptosis through a Direct Effect on Cell Nuclei

1999 • 98 citations

Recombinant Escherichia coli express a defined, cytoplasmic epitope that is efficiently processed in macrophage phagolysosomes for class II MHC presentation to T lymphocytes.

1992 • 59 citations

Parameters that influence the efficiency of processing antigenic epitopes expressed in Salmonella typhimurium

1994 • 58 citations

Classical MHC class I peptide presentation of a bacterial fusion protein by bone marrow-derived dendritic cells

1999 • 58 citations

Delivery of exogenous antigen into the major histocompatibility complex class I and class II pathways by electroporation

1994 • 29 citations