Cathepsin S Required for Normal MHC Class II Peptide Loading and Germinal Center Development

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.

1996 • 1,129 citations

Involvement of Granulocyte-Macrophage Colony-Stimulating Factor in Pulmonary Homeostasis

1994 • 883 citations

Assembly, Transport, and Function of MHC Class II Molecules

1994 • 791 citations

CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES

1997 • 779 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

1983 • 701 citations

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

1998 • 654 citations

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

1995 • 583 citations

Mediation by HLA-DM of dissociation of peptides from HLA-DR

1995 • 555 citations

Essential Role for Cathepsin S in MHC Class II–Associated Invariant Chain Processing and Peptide Loading

1996 • 523 citations

Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo.

1995 • 410 citations

Developmental Regulation of Invariant Chain Proteolysis Controls MHC Class II Trafficking in Mouse Dendritic Cells

1998 • 378 citations

Antigen-induced B-cell death and elimination during germinal-centre immune responses

1995 • 377 citations

Germinal center development

1997 • 370 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

Article

1995 • 325 citations

Cathepsin S activity regulates antigen presentation and immunity.

1998 • 307 citations

Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease.

1992 • 304 citations

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells

1995 • 301 citations

How MHC Class II Molecules Acquire Peptide Cargo: Biosynthesis and Trafficking through the Endocytic Pathway

1995 • 280 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

FLT3 Ligand Induces the Generation of Functionally Active Dendritic Cells in Mice

1997 • 193 citations

Human cathepsin S: chromosomal localization, gene structure, and tissue distribution

1994 • 193 citations

Degradation of Mouse Invariant Chain: Roles of Cathepsins S and D and the Influence of Major Histocompatibility Complex Polymorphism

1997 • 188 citations

The germinal center: a crucible for lymphocyte selection

1996 • 166 citations

Mapping of the T-Cell Epitope in the Major 43-Kilodalton Glycoprotein ofParacoccidioides brasiliensisWhich Induces a Th-1 Response Protective against Fungal Infection in BALB/c Mice

1998 • 161 citations

In Thymic Selection, Peptide Diversity Gives and Takes Away

1997 • 136 citations

Thymic Selection by a Single MHC/Peptide Ligand Produces a Semidiverse Repertoire of CD4+ T Cells

1997 • 134 citations

Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41

1992 • 124 citations

Diversity of Endogenous Epitopes Bound to MHC Class II Molecules Limited by Invariant Chain

1994 • 116 citations

Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus

1997 • 112 citations

Ii Chain Controls the Transport of Major Histocompatibility Complex Class II Molecules to and from Lysosomes

1997 • 92 citations

MHC genotype controls the capacity of ligand density to switch T helper (Th)-1/Th-2 priming in vivo.

1996 • 56 citations

Epitope-specific enhancement of antigen presentation by invariant chain.

1993 • 52 citations

Antigen dose-dependent differences in IgE antibody production are not due to polarization towards Th1 and Th2 cell subsets

1998 • 38 citations

Neither interleukin‐6 nor signalling via tumour necrosis factor receptor‐1 contribute to the adjuvant activity of Alum and Freund’s adjuvant

1998 • 32 citations

The Density of the Class II MHC T Cell Receptor Ligand Influences IFN-γ/IL-4 Ratios in Immune Responsesin Vivo

1998 • 25 citations

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