Invariant Chain Structure and MHC Class II Function

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Assembly, Transport, and Function of MHC Class II Molecules

1994 • 791 citations

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

1995 • 583 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

1991 • 326 citations

Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules

1994 • 234 citations

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.

1995 • 186 citations

In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides

1994 • 185 citations

The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy.

1994 • 184 citations

Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.

1995 • 150 citations

HLA-DM: An in vivo facilitator of MHC class II peptide loading

1995 • 74 citations

T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates.

1995 • 58 citations

Direct observation of disordered regions in the major histocompatibility complex class II-associated invariant chain.

1995 • 42 citations