Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

1998 • 2,047 citations

A family of human receptors structurally related to Drosophila Toll

1998 • 1,735 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Innate immune recognition: mechanisms and pathways

2000 • 1,451 citations

Consequences of Cell Death

2000 • 1,382 citations

The immune system evolved to discriminate infectious nonself from noninfectious self

1992 • 1,324 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Introduction of soluble protein into the class I pathway of antigen processing and presentation

1988 • 1,105 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

A Phagosome-to-Cytosol Pathway for Exogenous Antigens Presented on MHC Class I Molecules

1995 • 882 citations

A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

1995 • 838 citations

Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

1997 • 837 citations

Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages

1999 • 829 citations

An innate sense of danger

1998 • 752 citations

Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

1993 • 625 citations

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

1999 • 586 citations

A new foreign policy: MHC class I molecules monitor the outside world

1996 • 422 citations

An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes.

1988 • 417 citations

Regression of established macroscopic liver metastases after in situ transduction of a suicide gene.

1993 • 380 citations

Major Histocompatibility Complex Class I–restricted Cross-presentation Is Biased towards High Dose Antigens and Those Released during Cellular Destruction

1998 • 323 citations

Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.

1994 • 302 citations

Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.

1994 • 224 citations

Ionizing Radiation and Chemotherapeutic Drugs Induce Apoptosis in Lymphocytes in the Absence of FAS or Fadd/Mort1 Signaling

2000 • 142 citations

5-Fluorocytosine-induced eradication of murine adenocarcinomas engineered to express the cytosine deaminase suicide gene requires host immune competence and leaves an efficient memory.

1995 • 109 citations

Failure of Bcl‐2 to block cytochrome c redistribution during TRAIL‐induced apoptosis

2000 • 109 citations

Effect of enforced expression of human bcl-2 on Japanese encephalitis virus-induced apoptosis in cultured cells

1997 • 97 citations

Dendritic cell maturation is induced by mycoplasma infection but not by necrotic cells

2000 • 90 citations