Cathepsin S Controls the Trafficking and Maturation of Mhc Class II Molecules in Dendritic Cells

Dendritic cells and the control of immunity

1998 • 14,345 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

1999 • 1,880 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.

1996 • 1,129 citations

EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN BIOLOGY

1997 • 767 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1998 • 720 citations

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

1995 • 684 citations

Immunocytochemical localization of galactosyltransferase in HeLa cells: codistribution with thiamine pyrophosphatase in trans-Golgi cisternae.

1982 • 617 citations

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

1995 • 583 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.

1990 • 561 citations

Mediation by HLA-DM of dissociation of peptides from HLA-DR

1995 • 555 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

Essential Role for Cathepsin S in MHC Class II–Associated Invariant Chain Processing and Peptide Loading

1996 • 523 citations

Cathepsin S Required for Normal MHC Class II Peptide Loading and Germinal Center Development

1999 • 519 citations

Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors

1995 • 496 citations

GENERATION, TRANSLOCATION, AND PRESENTATION OF MHC CLASS I-RESTRICTED PEPTIDES

1995 • 428 citations

Impaired Invariant Chain Degradation and Antigen Presentation and Diminished Collagen-Induced Arthritis in Cathepsin S Null Mice

1999 • 408 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Developmental Regulation of Invariant Chain Proteolysis Controls MHC Class II Trafficking in Mouse Dendritic Cells

1998 • 378 citations

Two species of lysosomal organelles in cultured human fibroblasts

1979 • 360 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

Cathepsin S activity regulates antigen presentation and immunity.

1998 • 307 citations

How MHC Class II Molecules Acquire Peptide Cargo: Biosynthesis and Trafficking through the Endocytic Pathway

1995 • 280 citations

Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation

1998 • 266 citations

Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.

1991 • 234 citations

Major Histocompatibility Complex Class II Compartments in Human and Mouse B Lymphoblasts Represent Conventional Endocytic Compartments

1997 • 233 citations

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

1992 • 219 citations

Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface.

1996 • 210 citations

Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments

1995 • 198 citations

Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins.

1987 • 197 citations

FLT3 Ligand Induces the Generation of Functionally Active Dendritic Cells in Mice

1997 • 193 citations

Degradation of Mouse Invariant Chain: Roles of Cathepsins S and D and the Influence of Major Histocompatibility Complex Polymorphism

1997 • 188 citations

The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy.

1994 • 184 citations

Endosomal aspartic proteinases are required for invariant-chain processing.

1994 • 182 citations

Endosomal proteolysis and MHC class II function

1998 • 168 citations

MHC class II restricted antigen presentation

1997 • 165 citations

Purification and characterization of human lysosomal membrane glycoproteins

1989 • 163 citations

Dendritic cells : biology and clinical applications

1999 • 151 citations

Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.

1995 • 150 citations

Dendritic Cells: Biology and Clinical Applications

1999 • 139 citations

Mapping functional regions in the lumenal domain of the class II-associated invariant chain.

1994 • 122 citations

Characterization of a naturally processed MHC class II-restricted T-cell determinant of hen egg lysozyme

1989 • 111 citations

The selectivity of Cathepsin D Suggests an Involvement of the Enzyme in the Generation of T-cell Epitopes

1989 • 105 citations

Roles for Proteolysis and Trafficking in Notch Maturation and Signal Transduction

1998 • 92 citations

HLA-DM: An in vivo facilitator of MHC class II peptide loading

1995 • 74 citations

Dramatic Numerical Increase of Functionally Mature Dendritic Cells in FLT3 Ligand-Treated Mice

1997 • 66 citations

Destructive proteolysis by cysteine proteases in antigen presentation of ovalbumin

1995 • 63 citations

Structural analysis of proteolytic products of MHC class II-invariant chain complexes generated in vivo.

1993 • 62 citations

Processing of tetanus toxin by human antigen-presenting cells. Evidence for donor and epitope-specific processing pathways.

1989 • 62 citations

MHC class II transport from lysosomal compartments to the cell surface is determined by stable peptide binding, but not by the cytosolic domains of the alpha- and beta-chains.

1998 • 34 citations

MHC Class II Transport from Lysosomal Compartments to the Cell Surface Is Determined by Stable Peptide Binding, But Not by the Cytosolic Domains of the α- and β-Chains

1998 • 32 citations

Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties

1999 • 20 citations

Trafficking and Assembly of MHC Molecules: How Viruses Elude the Immune System

1995 • 6 citations