A receptor for phosphatidylserine-specific clearance of apoptotic cells

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

Membrane protein structure prediction

1992 • 1,680 citations

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

1990 • 871 citations

Prediction of the Coding Sequences of Unidentified Human Genes. IX. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro

1998 • 848 citations

Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

1992 • 818 citations

Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling

1998 • 774 citations

Human CD14 mediates recognition and phagocytosis of apoptotic cells

1998 • 685 citations

Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes.

1995 • 675 citations

Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways

1998 • 642 citations

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.

1992 • 605 citations

The Class B Scavenger Receptors SR-BI and CD36 Are Receptors for Anionic Phospholipids

1995 • 546 citations

Analysis of Dishevelled signalling pathways during Xenopus development

1996 • 402 citations

CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3).

1998 • 397 citations

Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells

1998 • 385 citations

C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180

1998 • 377 citations

Requirement for Croquemort in Phagocytosis of Apoptotic Cells in Drosophila

1999 • 371 citations

Cell motility driving mediolateral intercalation in explants of Xenopus laevis

1992 • 342 citations

Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-beta in macrophages that have ingested apoptotic cells.

1999 • 338 citations

Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain

1995 • 337 citations

Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis

1992 • 332 citations

CD36 Is Required for Phagocytosis of Apoptotic Cells by Human Macrophages That Use Either a Phosphatidylserine Receptor or the Vitronectin Receptor (αvβ3)

1998 • 321 citations

Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserine.

1995 • 293 citations

Dishevelled Proteins Lead to Two Signaling Pathways

1999 • 291 citations

Transcriptional and Translational Regulation of Inflammatory Mediator Production by Endogenous TGF-β in Macrophages That Have Ingested Apoptotic Cells

1999 • 282 citations

Labeling Neural Cells Using Adenoviral Gene Transfer of Membrane-Targeted GFP

1996 • 280 citations

The C. elegans Cell Corpse Engulfment Gene ced-7 Encodes a Protein Similar to ABC Transporters

1998 • 278 citations

Dishevelled: at the crossroads of divergent intracellular signaling pathways

1999 • 267 citations

Establishment of the Dorsal–Ventral Axis inXenopus Embryos Coincides with the Dorsal Enrichment of Dishevelled That Is Dependent on Cortical Rotation

1999 • 255 citations

Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3

1995 • 233 citations

Oriented cell divisions and cellular morphogenesis in the zebrafish gastrula and neurula: a time-lapse analysis

1998 • 232 citations

Zebrafish paraxial protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm

1998 • 224 citations

Cell cycles and clonal strings during formation of the zebrafish central nervous system

1994 • 221 citations

CD36 participates in the phagocytosis of rod outer segments by retinal pigment epithelium

1996 • 220 citations

Binding and Phagocytosis of Apoptotic Vascular Smooth Muscle Cells Is Mediated in Part by Exposure of Phosphatidylserine

1995 • 208 citations

Patterns of cell motility in the organizer and dorsal mesoderm of Xenopus laevis

1992 • 205 citations

Overexpression of the forebrain-specific homeobox genesix3induces rostral forebrain enlargement in zebrafish

1998 • 200 citations

Candidate Adaptor Protein CED-6 Promotes the Engulfment of Apoptotic Cells in C. elegans

1998 • 199 citations

A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphisms

1996 • 168 citations

Role of Class B Scavenger Receptor Type I in Phagocytosis of Apoptotic Rat Spermatogenic Cells by Sertoli Cells

1999 • 153 citations

Immune Clearance of Phosphatidylserine-expressing Cells by Phagocytes

1997 • 148 citations

Particle digestibility is required for induction of the phosphatidylserine recognition mechanism used by murine macrophages to phagocytose apoptotic cells.

1993 • 140 citations

Recognition of Phosphatidylserine on the Surface of Apoptotic Spermatogenic Cells and Subsequent Phagocytosis by Sertoli Cells of the Rat

1997 • 139 citations

Multiple systems for recognition of apoptotic lymphocytes by macrophages.

1997 • 133 citations

Cell surface exposure of phosphatidylserine during apoptosis is phylogenetically conserved

1998 • 131 citations

Cellular Mechanism Underlying Neural Convergent Extension inXenopus laevisEmbryos

1997 • 113 citations

Axis-inducing activities and cell fates of the zebrafish organizer

2000 • 108 citations

Phosphatidylinositides Bind to Plasma Membrane CD14 and Can Prevent Monocyte Activation by Bacterial Lipopolysaccharide

1998 • 94 citations

A polymorphic zebrafish line for genetic mapping using SSLPs on high-percentage agarose gels

1997 • 76 citations

A Novel Phosphatidylserine-binding Peptide Motif Defined by an Anti-idiotypic Monoclonal Antibody

1995 • 71 citations

Analysis of gastrulation: different types of gastrulation movement are induced by different mesoderm-inducing factors in Xenopus laevis

1993 • 52 citations

Negatively Charged Liposomes Inhibit Tyrosine Phosphorylation of 41-kDa Protein in Murine Macrophages Stimulated with LPS

1997 • 21 citations

Inhibition of Morphogenetic Movement duringXenopusGastrulation by Injected Sulfatase: Implications for Anteroposterior and Dorsoventral Axis Formation

1997 • 17 citations