CELL DEATH AND IMMUNE PRIVILEGE

The Fas Death Factor

1995 • 4,070 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

A role for CD95 ligand in preventing graft rejection

1995 • 1,184 citations

Expression of the Fas ligand in cells of T cell lineage.

1995 • 659 citations

Potential Involvement of Fas and Its Ligand in the Pathogenesis of Hashimoto's Thyroiditis

1997 • 584 citations

Prevention of Islet Allograft Rejection with Engineered Myoblasts Expressing FasL in Mice

1996 • 456 citations

Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction

1997 • 453 citations

TGF-β Released by Apoptotic T Cells Contributes to an Immunosuppressive Milieu

2001 • 414 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

CD95-Induced Apoptosis of Lymphocytes in an Immune Privileged Site Induces Immunological Tolerance

1996 • 394 citations

Regulation of the Proinflammatory Effects of Fas Ligand (CD95L)

1998 • 391 citations

Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand

1998 • 377 citations

CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival.

1997 • 375 citations

Transgenic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts

1997 • 373 citations

Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptus.

1997 • 291 citations

Evidence that DNA damage triggers interleukin 10 cytokine production in UV-irradiated murine keratinocytes.

1996 • 249 citations

Opposing Effects of Transmembrane and Soluble FAS Ligand Expression on Inflammation and Tumor Cell Survival

2000 • 236 citations

Antiinflammatory Effects of CD95 Ligand (FasL)-induced Apoptosis

1998 • 220 citations

Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses.

1990 • 215 citations

A vision of cell death: insights into immune privilege

1997 • 177 citations

Soluble Fas Ligand Is Chemotactic for Human Neutrophilic Polymorphonuclear Leukocytes

1999 • 175 citations

THE IMMUNE PRIVILEGE OF CORNEAL ALLOGRAFTS1

1999 • 175 citations

Inducible Nonlymphoid Expression of Fas Ligand Is Responsible for Superantigen-Induced Peripheral Deletion of T Cells

1998 • 155 citations

Fas and Fas ligand enhance the pathogenesis of experimental allergic encephalomyelitis, but are not essential for immune privilege in the central nervous system.

1997 • 155 citations

ROLE OF FAS-FAS LIGAND INTERACTIONS IN THE IMMUNOREJECTION OF ALLOGENEIC MOUSE CORNEAL TRANSPLANTS1

1997 • 147 citations

Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response

1998 • 141 citations

Testicular FasL is expressed by sperm cells

2001 • 141 citations

Dual Role for Fas Ligand in the Initiation of and Recovery from Experimental Allergic Encephalomyelitis

1999 • 137 citations

Fas ligand- mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease.

1998 • 125 citations

Fas-mediated apoptosis in clinical remissions of relapsing experimental autoimmune encephalomyelitis

2000 • 124 citations

Sunlight-induced basal cell carcinoma tumor cells and ultraviolet-B-irradiated psoriatic plaques express Fas ligand (CD95L).

1998 • 116 citations

Requirement for Transforming Growth Factor β1 in Controlling T Cell Apoptosis

2001 • 116 citations

Human retinal pigment epithelial cell-induced apoptosis in activated T cells.

1998 • 104 citations

Extracellular matrix interacts with soluble CD95L: Retention and enhancement of cytotoxicity

2001 • 91 citations

T-cell mediated responses in a murine model of orthotopic corneal transplantation.

1995 • 91 citations

The role of T cell apoptosis in transplantation tolerance

2000 • 83 citations

A Critical Role for Fas Ligand in the Active Suppression of Systemic Immune Responses by Ultraviolet Radiation

1999 • 77 citations

Fas-FasL Interaction Involved in Pathogenesis of Ocular Toxoplasmosis in Mice

1999 • 72 citations

Neuropeptides modulate immune deviation induced via the anterior chamber of the eye.

1995 • 71 citations

Fas Ligand (CD95L) Protects Neurons Against Perforin- Mediated T Lymphocyte Cytotoxicity

2001 • 69 citations

Tumor counterattack - concept and reality

2000 • 69 citations

PROLONGED SURVIVAL OF RAT LIVER ALLOGRAFTS TRANSFECTED WITH FAS LIGAND-EXPRESSING PLASMID1

1998 • 66 citations

Epithelium-deficient corneal allografts display immune privilege beneath the kidney capsule.

2000 • 61 citations

Antigen presenting cells expressing Fas ligand down-modulate chronic inflammatory disease in Fas ligand–deficient mice

2000 • 57 citations

Airway epithelial Fas ligand expression: potential role in modulating bronchial inflammation

1998 • 55 citations

Restricted Expression of an Adenoviral Vector Encoding Fas Ligand (CD95L) Enhances Safety for Cancer Gene Therapy

2000 • 53 citations

Fas Ligand Overexpression on Allograft Endothelium Inhibits Inflammatory Cell Infiltration and Transplant-Associated Intimal Hyperplasia

2001 • 53 citations

Efficient Fas-ligand gene expression in rodent liver after intravenous injection of a recombinant adenovirus by the use of a Cre-mediated switching system

1998 • 49 citations

Transgenic Expression of Fas Ligand on Thyroid Follicular Cells Prevents Autoimmune Thyroiditis

2000 • 48 citations

The immune response and the eye: a role for TNF alpha in anterior chamber-associated immune deviation.

1994 • 46 citations

Transgenic Expression of CD95 Ligand on Thyroid Follicular Cells Confers Immune Privilege upon Thyroid Allografts

2001 • 36 citations

Fas LIGAND-TRANSFECTED MYOBLASTS AND ISLET CELL TRANSPLANTATION1

2000 • 33 citations

Inhibition of lymphocyte proliferation by resident ocular cells

1991 • 31 citations

Anterior chamber inoculation of splenocytes without Fas/Fas‐ligand interaction primes for a delayed‐type hypersensitivity response rather than inducing anterior chamber‐associated immune deviation

1997 • 27 citations

MURINE XENOGENEIC IMMUNE RESPONSES TO THE HUMAN TESTIS: A PRESUMED IMMUNE-PRIVILEGED TISSUE1

2000 • 25 citations

Fas ligand-deficient gld mice are more susceptible to graft-versus-host-disease.

2000 • 24 citations

Selective Upregulation of Fibroblast Fas Ligand Expression, and Prolongation of Fas/Fas Ligand-Mediated Skin Allograft Survival, by Retinoic Acid: the Skin as a Retinoide-Inducible Immune Privilege Site

2000 • 22 citations

Fas/Apo-1 (CD95)-Mediated Apoptosis of Neutrophils with Fas Ligand (CD95L)-Expressing Tumors Is Crucial for Induction of Inflammation by Neutrophilic Polymorphonuclear Leukocytes Associated with Antitumor Immunity

2001 • 20 citations

The wavelength of light governing intraocular immune reactions.

1992 • 20 citations

Fas ligand gene transfer combined with low dose cyclosporine A reduces acute lung allograft rejection

2000 • 16 citations

Fas/Fas Ligand Pathway, Apoptosis, and Clonal Anergy Involved in Systemic Acetylcholine Receptor T Cell Epitope Tolerance

2001 • 16 citations

Characterization of a Novel Cis-element That Regulates Fas Ligand Expression in Corneal Endothelial Cells

1999 • 15 citations

Fas ligand gene transfer combined with low dose cyclosporine A reduces acute lung allograft rejection

2000 • 12 citations

The regulation by light of retinal necrosis and the immune response following anterior chamber inoculation of herpes simplex virus type-1

1993 • 4 citations