Transcriptional regulation in thymic epithelial cells for the establishment of self tolerance

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

2002 • 891 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100

2001 • 807 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

2005 • 744 citations

A CENTRAL ROLE FOR CENTRAL TOLERANCE

2006 • 730 citations

The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid Tissues

1998 • 710 citations

Central tolerance: learning self-control in the thymus

2005 • 641 citations

The Cellular Mechanism of Aire Control of T Cell Tolerance

2005 • 622 citations

Distinct Roles in Lymphoid Organogenesis for Lymphotoxins α and β Revealed in Lymphotoxin β–Deficient Mice

1997 • 590 citations

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

2005 • 540 citations

NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

1998 • 533 citations

Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation

2004 • 474 citations

The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor

2003 • 467 citations

Tolerance and Autoimmunity

2001 • 453 citations

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

1999 • 448 citations

Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Family: Adapter Proteins That Mediate Cytokine Signaling

2000 • 436 citations

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2004 • 424 citations

Biological functions of tumor necrosis factor cytokines and their receptors

2003 • 410 citations

Identification of α-Fodrin as a Candidate Autoantigen in Primary Sjögren's Syndrome

1997 • 400 citations

Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice

1997 • 365 citations

Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR

2003 • 361 citations

A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

1994 • 327 citations

Gene Dosage–limiting Role ofAirein Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity

2004 • 291 citations

Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice

2005 • 287 citations

Dependence of Self-Tolerance on TRAF6-Directed Development of Thymic Stroma

2005 • 272 citations

Targeted Disruption of LIGHT Causes Defects in Costimulatory T Cell Activation and Reveals Cooperation with Lymphotoxin β in Mesenteric Lymph Node Genesis

2002 • 255 citations

NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner

2004 • 207 citations

Essential Role of Nuclear Factor (NF)-κB–Inducing Kinase and Inhibitor of κb (Iκb) Kinase α in Nf-κb Activation through Lymphotoxin β Receptor, but Not through Tumor Necrosis Factor Receptor I

2001 • 200 citations

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 • 198 citations

Lymphotoxin pathway directs thymic Aire expression

2003 • 193 citations

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

2000 • 185 citations

The timing of TCRα expression critically influences T cell development and selection

2005 • 179 citations

Abnormal Immune Function of Hemopoietic Cells from Alymphoplasia (aly) Mice, a Natural Strain with Mutant NF-κB-Inducing Kinase

2000 • 164 citations

Differential Requirement for Rel/Nuclear Factor κB Family Members in Natural Killer T Cell Development

2003 • 158 citations

Lymphotoxin‐α‐deficient and TNF receptor‐I‐deficient mice define developmental and functional characteristics of germinal centers

1997 • 149 citations

AIRE Functions As an E3 Ubiquitin Ligase

2004 • 145 citations

Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: New views on molecular basis of autoimmunity

2005 • 127 citations

Chromosomal clustering of genes controlled by the aire transcription factor

2005 • 126 citations

NIK-dependent RelB Activation Defines a Unique Signaling Pathway for the Development of Vα14i NKT Cells

2003 • 120 citations

How defects in central tolerance impinge on a deficiency in regulatory T cells

2005 • 117 citations

Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice

2006 • 117 citations

Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: a spontaneous model for Sjören's syndrome

1996 • 91 citations

Essential Role of IκB Kinase α in Thymic Organogenesis Required for the Establishment of Self-Tolerance

2006 • 86 citations

Increased antigen presenting cell‐mediated T cell activation in mice and patients without the autoimmune regulator

2006 • 81 citations

Features of Medullary Thymic Epithelium Implicate Postnatal Development in Maintaining Epithelial Heterogeneity and Tissue-Restricted Antigen Expression

2006 • 79 citations

Characterization and Chromosomal Localization of a New Protein Disulfide Isomerase, PDIp, Highly Expressed in Human Pancreas

1996 • 76 citations

Subcellular Expression of Autoimmune Regulator Is Organized in a Spatiotemporal Manner

2004 • 71 citations

Contrasting models of promiscuous gene expression by thymic epithelium

2005 • 67 citations

Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis.

1999 • 61 citations

Molecular Characterization of a Pancreas-Specific Protein Disulfide Isomerase, PDIp

1997 • 48 citations

Generation of NK1.1⁺T cell antigen receptor α/β⁺thymocytes associated with intact thymic structure

1997 • 38 citations

Expression of Self-antigen in the Thymus

2003 • 31 citations

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