Therapies Based on Principles of Ocular Immune Privilege

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

2002 • 1,343 citations

Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

2001 • 1,212 citations

Ocular immune privilege: therapeutic opportunities from an experiment of nature

2003 • 744 citations

Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor.

1991 • 470 citations

Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation

2003 • 334 citations

Induction of anterior chamber-associated immune deviation requires an intact, functional spleen.

1981 • 255 citations

Studies on the induction of anterior chamber‐associated immune deviation (ACAID) III. Induction of ACAID depends upon intraocular transforming growth factor‐β

1992 • 250 citations

Mucosal CD8α⁺ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties

2003 • 231 citations

Immune response to immunization via the anterior chamber of the eye. I. F. lymphocyte-induced immune deviation.

1977 • 208 citations

Fluids from immune privileged sites endow macrophages with the capacity to induce antigen‐specific immune deviation via a mechanism involving transforming growth factor‐β

1992 • 206 citations

Pharmacological induction of tolerogenic dendritic cells and regulatory T cells

2004 • 192 citations

Studies on the induction of anterior chamber-associated immune deviation (ACAID). 1. Evidence that an antigen-specific, ACAID-inducing, cell-associated signal exists in the peripheral blood.

1991 • 179 citations

MIP-2 Recruits NKT Cells to the Spleen During Tolerance Induction

2001 • 177 citations

Characterization of suppressor cells in anterior chamber-associated immune deviation (ACAID) induced by soluble antigen. Evidence of two functionally and phenotypically distinct T-suppressor cell populations.

1990 • 172 citations

Deviant immune responses to allogeneic tumors injected intracamerally and subcutaneously in mice.

1981 • 156 citations

Impaired cell-mediated immunity in mice bearing healthy orthotopic corneal allografts.

1993 • 155 citations

Studies on the induction of anterior chamber-associated immune deviation (ACAID). II. Eye-derived cells participate in generating blood-borne signals that induce ACAID.

1991 • 144 citations

Regulatory T cells and tolerogenic dendritic cells: from basic biology to clinical applications

2004 • 143 citations

CD1d on antigen-transporting APC and splenic marginal zone B cells promotes NKT cell-dependent tolerance

2002 • 135 citations

Characterization of the suppressor cell(s) responsible for anterior chamber-associated immune deviation (ACAID) induced in BALB/c mice by P815 cells.

1985 • 118 citations

Anterior chamber-associated immune deviation promotes corneal allograft survival.

1996 • 115 citations

Cutting Edge: In Vitro-Generated Tolerogenic APC Induce CD8+ T Regulatory Cells That Can Suppress Ongoing Experimental Autoimmune Encephalomyelitis

2004 • 109 citations

Alloantigens placed into the anterior chamber of the eye induce specific suppression of delayed-type hypersensitivity but normal cytotoxic T lymphocyte and helper T lymphocyte responses.

1983 • 105 citations

Role of dendritic cells in the generation of regulatory T cells

2004 • 105 citations

Splenic B cells are required for tolerogenic antigen presentation in the induction of anterior chamber‐associated immune deviation (ACAID)

1998 • 93 citations

Immune response to immunization via the anterior chamber of the eye. II. An analysis of F1 lymphocyte-induced immune deviation.

1978 • 93 citations

Suppression of experimental autoimmune uveitis in mice by induction of anterior chamber-associated immune deviation with interphotoreceptor retinoid-binding protein.

1992 • 90 citations

Macrophages capable of inducing anterior chamber associated immune deviation demonstrate spleen-seeking migratory properties.

1992 • 87 citations

Characterization of cell-mediated immune responses elicited by orthotopic corneal allografts in mice.

1995 • 85 citations

Analysis of an in vitro-generated signal that induces systemic immune deviation similar to that elicited by antigen injected into the anterior chamber of the eye

1992 • 77 citations

Transplantation immunology of the anterior chamber of the eye. II. Immune response to allogeneic cells.

1975 • 74 citations

Ocular Immune Privilege Promoted by the Presentation of Peptide on Tolerogenic B Cells in the Spleen. II. Evidence for Presentation by Qa-1

2001 • 71 citations

Evidence that peritoneal exudate cells cultured with eye-derived fluids are the proximate antigen-presenting cells in immune deviation of the ocular type.

1993 • 71 citations

Using Tolerance Induced Via the Anterior Chamber of the Eye to Inhibit Th2-Dependent Pulmonary Pathology

2002 • 66 citations

Do immunologically privileged sites require a functioning spleen?

1974 • 65 citations

Expression of Thrombospondin in TGFβ-Treated APCs and Its Relevance to Their Immune Deviation-Promoting Properties

2002 • 62 citations

Imposing deviant immunity on the presensitized state.

1994 • 59 citations

In vitro generation of regulatory CD8+ T cells similar to those found in mice with anterior chamber-associated immune deviation.

2000 • 52 citations

Immunobiology and Immunopathology of Corneal Transplantation

1999 • 51 citations

CD8⁺T Regulatory Cells Use a Novel Genetic Program that Includes CD103 to Suppress Th1 Immunity in Eye-Derived Tolerance

2006 • 50 citations

CD8α+, but Not CD8α−, Dendritic Cells Tolerize Th2 Responses via Contact-Dependent and -Independent Mechanisms, and Reverse Airway Hyperresponsiveness, Th2, and Eosinophil Responses in a Mouse Model of Asthma

2005 • 49 citations

Splenic B Cells Act as Antigen Presenting Cells for the Induction of Anterior Chamber-Associated Immune Deviation

2003 • 47 citations

Evidence for Antigen-Specific Immune Deviation in Patients With Acute Retinal Necrosis

2001 • 47 citations

Role of splenic B cells in the immune privilege of the anterior chamber of the eye

1995 • 38 citations

Analysis of in vivo regulatory properties of T cells activated in vitro by TGFbeta2-treated antigen presenting cells.

2000 • 38 citations

Tolerogenic APC Generate CD8+ T Regulatory Cells That Modulate Pulmonary Interstitial Fibrosis

2004 • 33 citations

ACAID induced by allogeneic corneal tissue promotes subsequent survival of orthotopic corneal grafts.

2000 • 33 citations

Modulation of Ovalbumin-Induced Airway Inflammation and Hyperreactivity by Tolerogenic APC

2005 • 31 citations

Mechanisms of tolerance induced by transforming growth factor- -treated antigen-presenting cells: CD8 regulatory T cells inhibit the effector phase of the immune response in primed mice through a mechanism involving Fas ligand

2004 • 26 citations

Functional analysis of cloned macrophage hybridomas. VI. Differential ability to induce immunity or suppression.

1988 • 18 citations

Mechanisms of Peripheral Tolerance following Intracameral Inoculation Are Independent of IL-13 or STAT6

2005 • 16 citations

Histopathologic analysis of experimental autoimmune uveitis attenuated by intracameral injection of S-antigen

1989 • 16 citations