Considering Fas ligand as a target for therapy

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

A role for CD95 ligand in preventing graft rejection

1995 • 1,184 citations

Lymphocyte-Mediated Cytotoxicity

2002 • 1,079 citations

The CD95(APO-1/Fas) DISC and beyond

2003 • 1,064 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

The Immunological Synapse of CTL Contains a Secretory Domain and Membrane Bridges

2001 • 796 citations

Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity

1998 • 789 citations

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

1998 • 781 citations

Fas Ligand-Induced Apoptosis

1999 • 778 citations

Fas ligand in human serum

1996 • 682 citations

Downregulation of Fas ligand by shedding

1998 • 681 citations

Expression of the functional soluble form of human fas ligand in activated lymphocytes.

1995 • 656 citations

Secretory lysosomes

2002 • 633 citations

Potential Involvement of Fas and Its Ligand in the Pathogenesis of Hashimoto's Thyroiditis

1997 • 584 citations

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1992 • 540 citations

Membrane Fas Ligand Kills Human Peripheral Blood T Lymphocytes, and Soluble Fas Ligand Blocks the Killing

1997 • 503 citations

FasGene Mutations in the Canale–Smith Syndrome, an Inherited Lymphoproliferative Disorder Associated with Autoimmunity

1996 • 486 citations

Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.

1996 • 473 citations

Immune escape of tumors: apoptosis resistance and tumor counterattack

2002 • 453 citations

Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation

2002 • 442 citations

The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis

1999 • 421 citations

CD95(APO-1/Fas)-Mediated Apoptosis: Live and Let Die

1998 • 405 citations

Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1

1999 • 388 citations

Two Adjacent Trimeric Fas Ligands Are Required for Fas Signaling and Formation of a Death-Inducing Signaling Complex

2003 • 387 citations

Linking Albinism and Immunity: The Secrets of Secretory Lysosomes

2004 • 361 citations

Somatic Fas Mutations in Non-Hodgkin’s Lymphoma: Association With Extranodal Disease and Autoimmunity

1998 • 324 citations

Wiskott-Aldrich Syndrome Protein Physically Associates with Nck through Src Homology 3 Domains

1995 • 315 citations

Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptus.

1997 • 291 citations

Immunity to cancer: attack and escape in T lymphocyte–tumor cell interaction

2002 • 280 citations

The role of Fas ligand in immune privilege

2001 • 276 citations

Regulation of Fas-Ligand Expression during Activation-induced Cell Death in T Lymphocytes via Nuclear Factor κB

1999 • 257 citations

Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape

2000 • 256 citations

Fas Ligand: A Sensor for DNA Damage Critical in Skin Cancer Etiology

1999 • 254 citations

Gene transfer of Fas ligand induces tumor regression in vivo

1997 • 247 citations

The Fas counterattack: cancer as a site of immune privilege

1999 • 240 citations

Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways

2003 • 234 citations

Two NFAT Transcription Factor Binding Sites Participate in the Regulation of CD95 (Fas) Ligand Expression in Activated Human T Cells

1997 • 222 citations

Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas

2002 • 222 citations

Maximal Proliferation of Cytotoxic T Lymphocytes Requires Reverse Signaling through Fas Ligand

1998 • 217 citations

Effective Treatment of Established Murine Collagen-Induced Arthritis by Systemic Administration of Dendritic Cells Genetically Modified to Express IL-4

2001 • 217 citations

Enhanced and accelerated lymphoproliferation in Fas-null mice.

1996 • 211 citations

Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury

2004 • 209 citations

Identification and Characterization of a Pro-tumor Necrosis Factor-α-processing Enzyme from the ADAM Family of Zinc Metalloproteases

1997 • 204 citations

Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligand-induced apoptosis and chemotaxis.

2001 • 203 citations

A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in `reverse signalling'

1999 • 198 citations

Stress-Induced Fas Ligand Expression in T Cells Is Mediated through a MEK Kinase 1-Regulated Response Element in the Fas Ligand Promoter

1998 • 193 citations

Soluble Fas Ligand Is Chemotactic for Human Neutrophilic Polymorphonuclear Leukocytes

1999 • 175 citations

Fas ligand (CD95 ligand) controls angiogenesis beneath the retina

1999 • 168 citations

Cyclosporin A-Sensitive Transcription Factor Egr-3 Regulates Fas Ligand Expression

1998 • 164 citations

Signaling and transcriptional control of Fas ligand gene expression

2003 • 162 citations

Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail

2001 • 161 citations

Chemotactic activity of soluble Fas ligand against phagocytes.

1998 • 159 citations

Immune privilege or inflammation? Insights into the Fas ligand enigma

2001 • 159 citations

Chronic lymphadenopathy simulating malignant lymphoma

1966 • 159 citations

Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand

2002 • 151 citations

Lytic granules, secretory lysosomes and disease

2003 • 143 citations

gld/gld mice are unable to express a functional ligand for Fas

1994 • 140 citations

The Wiskott-Aldrich Syndrome Protein-interacting Protein (WIP) Binds to the Adaptor Protein Nck

1998 • 139 citations

Cell-death signaling and human disease

2003 • 130 citations

Cleavage of CD95 by matrix metalloproteinase-7 induces apoptosis resistance in tumour cells

2004 • 129 citations

Fas ligation on macrophages enhances IL-1R1–Toll-like receptor 4 signaling and promotes chronic inflammation

2004 • 128 citations

The Fas signalling pathway and its role in the pathogenesis of cancer

2004 • 125 citations

The dual functions of Fas ligand in the regulation of peripheral CD8⁺and CD4⁺T cells

2000 • 123 citations

Fas Ligand Exists on Intervertebral Disc Cells: A Potential Molecular Mechanism for Immune Privilege of the Disc

2002 • 117 citations

Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system

2003 • 117 citations

Newly discovered role for Fas ligand in the cell-cycle arrest of CD4+ T cells

1998 • 109 citations

Effective Treatment of Established Mouse Collagen-Induced Arthritis by Systemic Administration of Dendritic Cells Genetically Modified to Express FasL

2002 • 98 citations

Pancreatic cancer cells can evade immune surveillance via nonfunctional Fas (APO-1/CD95) receptors and aberrant expression of functional Fas ligand

1999 • 98 citations

Roles of Fas and Fas ligand during mammary gland remodeling

2000 • 97 citations

CELL DEATH AND IMMUNE PRIVILEGE

2002 • 97 citations

Release of preformed Fas ligand in soluble form is the major factor for activation‐induced death of Jurkat T cells

1996 • 94 citations

The IFN Regulatory Factor Family Participates in Regulation of Fas Ligand Gene Expression in T Cells

2000 • 94 citations

Effective Treatment of Established Mouse Collagen-Induced Arthritis by Systemic Administration of Dendritic Cells Genetically Modified to Express FasL

2002 • 87 citations

Regulation of activation-induced cell death of mature T-lymphocyte populations

2000 • 87 citations

The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity

2001 • 86 citations

Role of Egr-2 in Up-regulation of Fas Ligand in Normal T Cells and Aberrant Double-negative lpr and gld T Cells

1999 • 86 citations

Expression of Fas Ligand in Activated T Cells Is Regulated by c-Myc

2000 • 84 citations

Treatment of Experimental Glioma by Administration of Adenoviral Vectors Expressing Fas Ligand

1999 • 83 citations

Autocrine Secretion of Fas Ligand Shields Tumor Cells from Fas-Mediated Killing by Cytotoxic Lymphocytes

2004 • 78 citations

Complete Loss of Fas Ligand Gene Causes Massive Lymphoproliferation and Early Death, Indicating a Residual Activity of gld Allele

2004 • 75 citations

Prevention of Hepatocellular Carcinoma Development Associated with Chronic Hepatitis by Anti-Fas Ligand Antibody Therapy

2002 • 74 citations

Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo.

2002 • 68 citations

Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death

2002 • 63 citations

A Casein Kinase I Activity Is Constitutively Associated with Nck

1997 • 62 citations

Expression of Fas Ligand and Its Receptor in Cutaneous Lupus: Implication in Tissue Injury

1997 • 62 citations

Interaction of peptides derived from the Fas ligand with the Fyn‐SH3 domain

1995 • 60 citations

Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death

2002 • 58 citations

Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor¹

2001 • 56 citations

Airway epithelial Fas ligand expression: potential role in modulating bronchial inflammation

1998 • 55 citations

SLP-76 Binding to p56lck: A Role for SLP-76 in CD4-Induced Desensitization of the TCR/CD3 Signaling Complex

1999 • 55 citations

Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178)¹

2002 • 54 citations

Differential Expression of Fas Ligand in Th1 and Th2 Cells Is Regulated by Early Growth Response Gene and NF-AT Family Members

2001 • 52 citations

In vitro efficacy of Fas ligand gene therapy for the treatment of bladder cancer

2004 • 47 citations

The anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells

2002 • 38 citations

The Use of Fas Ligand, TRAIL and Bax in Gene Therapy of Prostate Cancer

2001 • 35 citations

Expression of Fas ligand improves the effect of IL-4 in collagen-induced arthritis

2000 • 33 citations

Mutation in Fas Ligand Impairs Maturation of Thymocytes Bearing Moderate Affinity T Cell Receptors

2003 • 29 citations

Fas Ligand Gene Therapy for Vascular Intimal Hyperplasia

2004 • 29 citations

Ligation of cell surface CD4 inhibits activation-induced death of human T lymphocytes at the level of Fas ligand expression.

1997 • 27 citations

Engagement of Tumor Necrosis Factor mRNA by an Endotoxin-Inducible Cytoplasmic Protein

1996 • 26 citations

Activation‐dependent FasL expression in T lymphocytes and Natural Killer cells

2004 • 26 citations

Adenovirus expressing Fas ligand gene decreases airway hyper-responsiveness and eosinophilia in a murine model of asthma

2004 • 25 citations

Enhanced apoptosis of glioma cell lines is achieved by co-delivering FasL-GFP and TRAIL with a complex Ad5 vector

2003 • 25 citations

Differential Regulation of Activation-Induced Cell Death in Individual Human T Cell Clones

2000 • 24 citations

High Endothelial Venules of the Lymph Nodes Express Fas Ligand

2004 • 22 citations

Sorting out the multiple roles of Fas ligand

2000 • 22 citations

The Fas ligand as a cell death factor and signal transducer

2003 • 17 citations

Albinism and Immunity: Whats the Link?

2002 • 16 citations

Fas ligand-dependent suppression of autoimmunity via recruitment and subsequent termination of activated T cells

2004 • 12 citations

Differential role of tyrosine phosphorylation in the induction of apoptosis in T cell clones via CD95 or the TCR/CD3-complex

1997 • 9 citations

Mutational analysis of Fas ligand gene in human non‐Hodgkin lymphoma

2003 • 3 citations