Primer: mechanisms of immunologic tolerance

Innate Immune Recognition

2002 • 8,157 citations

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

2003 • 2,181 citations

Predominant Autoantibody Production by Early Human B Cell Precursors

2003 • 1,966 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

T Cell Anergy

2003 • 1,418 citations

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

2005 • 856 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

The Regulatory Role of Vα14 NKT Cells in Innate and Acquired Immune Response

2003 • 673 citations

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

2003 • 574 citations

A NEW ANALYSIS OF ALLOGENEIC INTERACTIONS

1975 • 551 citations

Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

1993 • 514 citations

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

2004 • 512 citations

Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

1996 • 451 citations

Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling

1997 • 383 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

POSITIVE VERSUS NEGATIVE SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

1998 • 320 citations

Regulation of immunity by self-reactive T cells

2005 • 306 citations

Natural regulatory T cells and self-tolerance

2005 • 234 citations

ORAL TOLERANCE FOR THE TREATMENT OF AUTOIMMUNE DISEASES

1997 • 193 citations

Regulatory Roles for Cytokine- Producing B Cells in Infection and Autoimmune Disease

2004 • 181 citations

Activation rules: the two-signal theories of immune activation

2002 • 154 citations

Autoreactivity, dynamic tuning and selectivity

2001 • 130 citations

Adaptive Tolerance of CD4+ T Cells In Vivo: Multiple Thresholds in Response to a Constant Level of Antigen Presentation

2001 • 124 citations

Different faces of regulatory DCs in homeostasis and immunity

2005 • 117 citations

The genetic background of autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy and its autoimmune disease components

2002 • 114 citations

The regulation of lymphocyte activation by inhibitory receptors

2004 • 98 citations

The Strength of Persistent Antigenic Stimulation Modulates Adaptive Tolerance in Peripheral CD4+ T Cells

2003 • 95 citations

Antigen receptor selection by editing or downregulation of V(D)J recombination

2003 • 82 citations

Immune Regulation by Self-Reactive T Cells is Antigen Specific

2004 • 76 citations

An immunoglobulin Cκ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system

2005 • 65 citations

Signaling control of memory T cell generation and function

2004 • 64 citations

CD5, An Important Regulator of Lymphocyte Selection and Immune Tolerance

2002 • 58 citations

Regulating self-tolerance by deregulating gene expression

2004 • 54 citations

Clonal anergy of B cells: a flexible, reversible, and quantitative concept.

1996 • 42 citations

The role of self-peptides in the development of CD4+ CD25+ regulatory T cells

2005 • 39 citations

Fine-tuning lymphocyte regulation: what’s new with tyrosine kinases and phosphatases?

2004 • 34 citations

Conceptual Models in Immunity/Tolerance: Application to Transplantation

2004 • 9 citations