A vision of cell death: Fas ligand and immune privilege 10 years later

Apoptosis by Death Factor

1997 • 5,038 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Infectious immunological tolerance.

1971 • 811 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Activation‐induced cell death in T cells

2003 • 613 citations

Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction

1997 • 453 citations

CD95-Induced Apoptosis of Lymphocytes in an Immune Privileged Site Induces Immunological Tolerance

1996 • 394 citations

Regulation of the Proinflammatory Effects of Fas Ligand (CD95L)

1998 • 391 citations

CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival.

1997 • 375 citations

Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation

2003 • 334 citations

Mechanisms of retinal and choroidal neovascularization.

1994 • 288 citations

Induction of anterior chamber-associated immune deviation requires an intact, functional spleen.

1981 • 255 citations

Opposing Effects of Transmembrane and Soluble FAS Ligand Expression on Inflammation and Tumor Cell Survival

2000 • 236 citations

Antiinflammatory Effects of CD95 Ligand (FasL)-induced Apoptosis

1998 • 220 citations

Enhanced and accelerated lymphoproliferation in Fas-null mice.

1996 • 211 citations

ANTERIOR CHAMBER ASSOCIATED IMMUNE DEVIATION (ACAID): REGULATION, BIOLOGICAL RELEVANCE, AND IMPLICATIONS FOR THERAPY

2002 • 210 citations

Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis.

1997 • 204 citations

Uptake of Apoptotic Antigen-Coupled Cells by Lymphoid Dendritic Cells and Cross-Priming of CD8+ T Cells Produce Active Immune Unresponsiveness

2002 • 193 citations

A vision of cell death: insights into immune privilege

1997 • 177 citations

Fas ligand (CD95 ligand) controls angiogenesis beneath the retina

1999 • 168 citations

Qa-1 restriction of CD8+ suppressor T cells

2004 • 142 citations

T cell vaccination induces T cell receptor Vβ-specific Qa-1-restricted regulatory CD8⁺T cells

1998 • 140 citations

By Altering Ocular Immune Privilege, Bone Marrow–derived Cells Pathogenically Contribute to DBA/2J Pigmentary Glaucoma

2003 • 114 citations

Identification of the genes differentially expressed in human dendritic cell subsets by cDNA subtraction and microarray analysis

2002 • 109 citations

Dual Immunological Unresponsiveness Induced by Cell Membrane Coupled Hapten or Antigen*

1966 • 108 citations

TRAIL: A Mechanism of Tumor Surveillance in an Immune Privileged Site

2002 • 104 citations

Iris Pigment Epithelium Expressing CD86 (B7-2) Directly Suppresses T Cell Activation In Vitro via Binding to Cytotoxic T Lymphocyte–associated Antigen 4

2003 • 98 citations

Distinctive humoral immune responses following anterior chamber and intravenous administration of soluble antigen. Evidence for active suppression of IgG2-secreting B lymphocytes.

1990 • 97 citations

Tumor counterattack: fact or fiction?

2005 • 94 citations

Extracellular matrix interacts with soluble CD95L: Retention and enhancement of cytotoxicity

2001 • 91 citations

Addressing the “Fas Counterattack” Controversy: Blocking Fas Ligand Expression Suppresses Tumor Immune Evasion of Colon CancerIn vivo

2005 • 87 citations

Membrane Fas Ligand Activates Innate Immunity and Terminates Ocular Immune Privilege

2002 • 81 citations

Immune Privilege and Immunogenicity Reside among Different Layers of the Mouse Cornea

2007 • 76 citations

Complete Loss of Fas Ligand Gene Causes Massive Lymphoproliferation and Early Death, Indicating a Residual Activity of gld Allele

2004 • 75 citations

Cutting Edge: Inflammatory Signals Drive Organ-Specific Autoimmunity to Normally Cross-Tolerizing Endogenous Antigen

2002 • 75 citations

Fas-FasL Interaction Involved in Pathogenesis of Ocular Toxoplasmosis in Mice

1999 • 72 citations

Regulation of Fas Ligand-Induced Apoptosis by TNF

2001 • 64 citations

Die Entwickelung der in fremden Grund versetzten lebenden Gewebe

1873 • 62 citations

Apoptosis, tolerance, and regulatory T cells – old wine, new wineskins

2003 • 58 citations

Antigen from the Anterior Chamber of the Eye Travels in a Soluble Form to Secondary Lymphoid Organs via Lymphatic and Vascular Routes

2006 • 57 citations

Fas Ligand but Not Complement Is Critical for Control of ExperimentalStaphylococcus aureusEndophthalmitis

2005 • 53 citations

FasL-Fas Interactions Regulate Neovascularization in the Cornea

2003 • 52 citations

The Role of Fas-FasL in the Development and Treatment of Ischemic Retinopathy

2003 • 48 citations

The effect of Freund's adjuvants on blood-cerebrospinal fluid barrier permeability

1984 • 47 citations

Fas and Fas Ligand Expressed on Cells of the Immune System, not on the Target Tissue, Control Induction of Experimental Autoimmune Uveitis

2000 • 42 citations

Peripheral Deletion of Antigen-Specific T Cells Leads to Long-Term Tolerance Mediated by CD8+ Cytotoxic Cells

2005 • 37 citations

Resident tissue macrophages within the normal rat iris lack immunosuppressive activity and are effective antigen-presenting cells

2000 • 18 citations

Resident tissue macrophages within the normal rat iris lack immunosuppressive activity and are effective antigen-presenting cells

2000 • 16 citations

Sympathetic ophthalmia, a genuine autoimmune disease

1990 • 8 citations