TRANSCRIPTIONAL REGULATION DURING B CELL DEVELOPMENT

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

NF-κB: Ten Years After

1996 • 3,008 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

Germinal Centers

1994 • 1,680 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994 • 1,506 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

1996 • 1,195 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

1996 • 1,115 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein

1993 • 1,083 citations

Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy gene

1986 • 1,033 citations

The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

1990 • 993 citations

The ikaros gene is required for the development of all lymphoid lineages

1994 • 976 citations

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

1993 • 955 citations

Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6

1997 • 921 citations

Jaks and Stats in signaling by the cytokine receptor superfamily

1995 • 902 citations

Sequence-Specific DNA Binding by the c-Myc Protein

1990 • 893 citations

Interleukin-6 and Its Receptor: A Paradigm for Cytokines

1992 • 889 citations

B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo

1985 • 859 citations

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

1994 • 856 citations

Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

1994 • 854 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1994 • 807 citations

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development

1995 • 800 citations

T Cell-Independent Antigens Type 2

1995 • 798 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

myc FUNCTION AND REGULATION

1992 • 790 citations

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

1994 • 766 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells

1994 • 752 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1995 • 710 citations

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

1995 • 703 citations

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

1993 • 691 citations

The helix-loop-helix gene E2A is required for B cell formation

1994 • 679 citations

Failure of B-cell differentiation in mice lacking the transcription factor EBF

1995 • 667 citations

Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice

1995 • 663 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

1996 • 630 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

Selective Defects in the Development of the Fetal and Adult Lymphoid System in Mice with an Ikaros Null Mutation

1996 • 619 citations

Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins.

1991 • 601 citations

LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.

1990 • 599 citations

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

1995 • 596 citations

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

1993 • 587 citations

Generation of Memory B Cells and Plasma Cells in Vitro

1995 • 585 citations

The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.

1990 • 584 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

BCL-6 protein is expressed in germinal-center B cells

1995 • 582 citations

Origin of Murine B Cell Lineages

1993 • 579 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.

1984 • 564 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Abnormal B lymphocyte delevopment, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule

1995 • 546 citations

Sequences and Factors: A Guide to MHC Class-II Transcription

1992 • 540 citations

IL‐6 and NF‐IL6 in Acute‐Phase Response and Viral Infection

1992 • 540 citations

Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages

1995 • 532 citations

Apoptosis: Activate NF-κB or die?

1997 • 524 citations

Mechanism and Regulation of Immunoglobulin Isotype Switching

1993 • 516 citations

Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

1993 • 509 citations

B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation

1997 • 499 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

REGULATION OF MHC CLASS II GENES: Lessons from a Disease

1996 • 488 citations

TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif.

1990 • 484 citations

ON IMMUNOLOGICAL MEMORY

1996 • 482 citations

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

1995 • 481 citations

Two Distinct Transcription Factors that Bind the Immunoglobulin Enhancer μE5/κE2 Motif

1990 • 478 citations

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

1995 • 475 citations

Ikaros, an Early Lymphoid-Specific Transcription Factor and a Putative Mediator for T Cell Commitment

1992 • 458 citations

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

1995 • 451 citations

Immunoglobulin class switching

1996 • 446 citations

BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor.

1996 • 434 citations

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300

1997 • 428 citations

Cloning and Characterization of Subunits of the T-Cell Receptor and Murine Leukemia Virus Enhancer Core-Binding Factor

1993 • 425 citations

The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins.

1994 • 424 citations

Somatic Hypermutation of Immunoglobulin Genes Is Linked to Transcription Initiation

1996 • 424 citations

Repression of c- myc Transcription by Blimp-1, an Inducer of Terminal B Cell Differentiation

1997 • 412 citations

Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

1997 • 411 citations

CCAAT Enhancer-Binding Protein (C/EBP) and AML1 (CBFα2) Synergistically Activate the Macrophage Colony-Stimulating Factor Receptor Promoter

1996 • 399 citations

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

1987 • 398 citations

Identification of the Earliest B Lineage Stage in Mouse Bone Marrow

1996 • 395 citations

B cell differentiation and isotype switching is related to division cycle number.

1996 • 393 citations

Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers

1996 • 386 citations

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1994 • 382 citations

Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development.

1996 • 379 citations

Antigen-induced B-cell death and elimination during germinal-centre immune responses

1995 • 377 citations

OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins

1995 • 374 citations

Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

1995 • 363 citations

PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity.

1992 • 362 citations

Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation

1997 • 360 citations

Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.

1994 • 358 citations

Mice Lacking the MHC Class II Transactivator (CIITA) Show Tissue-Specific Impairment of MHC Class II Expression

1996 • 356 citations

Identification and characterization of a novel repressor of beta-interferon gene expression.

1991 • 351 citations

Differential Requirements for α4 Integrins during Fetal and Adult Hematopoiesis

1996 • 347 citations

Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain

1993 • 345 citations

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

1986 • 344 citations

B-Lymphocyte Development Is Regulated by the Combined Dosage of Three Basic Helix-Loop-Helix Genes, E2A, E2-2, and HEB†

1996 • 339 citations

Defective activation and survival of T cells lacking the Ets-1 transcription factor

1995 • 329 citations

The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.

1992 • 325 citations

The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor.

1992 • 324 citations

Affinity maturation without germinal centres in lymphotoxin-α-deficient mice

1996 • 322 citations

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.

1990 • 318 citations

Expansion and functional activity of Ly‐1⁺ B cells upon transfer of peritoneal cells into allotype‐congenic, newborn mice

1987 • 318 citations

Life and Death in Germinal Centers (Redux)

1996 • 315 citations

Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene

1995 • 313 citations

HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.

1992 • 312 citations

Within Germinal Centers, Isotype Switching of Immunoglobulin Genes Occurs after the Onset of Somatic Mutation

1996 • 310 citations

CD19 Antigen in Leukemia and Lymphoma Diagnosis and Immunotherapy

1995 • 305 citations

Cloning of a Lymphoid-Specific cDNA Encoding a Protein Binding the Regulatory Octamer DNA Motif

1988 • 304 citations

B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching.

1996 • 304 citations

A B-cell coactivator of octamer-binding transcription factors

1995 • 301 citations

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells

1995 • 301 citations

CD22, A B LYMPHOCYTE–SPECIFIC ADHESION MOLECULE THAT REGULATES ANTIGEN RECEPTOR SIGNALING^*

1997 • 296 citations

ACCESSIBILITY CONTROL OF ANTIGEN-RECEPTOR VARIABLE-REGION GENE ASSEMBLY: Role ofcis-Acting Elements

1996 • 295 citations

Immunoglobulin Gene Transcription

1991 • 294 citations

Regulation of an Early Developmental Checkpoint in the B Cell Pathway by Igβ

1996 • 294 citations

Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

1996 • 290 citations

B-cell-specif ic coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation

1996 • 284 citations

The RAG1 and RAG2 Proteins Establish the 12/23 Rule in V(D)J Recombination

1996 • 281 citations

Requirements for Interleukin-4-Induced Gene Expression and Functional Characterization of Stat6

1996 • 279 citations

Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation

1993 • 278 citations

PU.1 Functions in a Cell-Autonomous Manner to Control the Differentiation of Multipotential Lymphoid–Myeloid Progenitors

1997 • 276 citations

Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation

1994 • 275 citations

Cloning, Functional Characterization, and Mechanism of Action of the B-Cell-Specific Transcriptional Coactivator OCA-B

1995 • 273 citations

Neoteny in Lymphocytes: Rag1 and Rag2 Expression in Germinal Center B Cells

1996 • 272 citations

A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors

1992 • 272 citations

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

1994 • 267 citations

Class II transactivator regulates the expression of multiple genes involved in antigen presentation.

1995 • 267 citations

Constitutive expression of the Id1 gene impairs mouse B cell development

1994 • 266 citations

Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival.

1993 • 265 citations

THE ROLE OF THE IKAROS GENE IN LYMPHOCYTE DEVELOPMENT AND HOMEOSTASIS

1997 • 262 citations

BCL-6 expression during B-cell activation

1996 • 262 citations

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

1984 • 261 citations

Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression.

1993 • 256 citations

CD28 is required for germinal center formation.

1996 • 251 citations

Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement.

1994 • 250 citations

Switch Transcripts in Immunoglobulin Class Switching

1995 • 248 citations

Somatic hypermutation

1995 • 248 citations

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

1994 • 245 citations

A helix-loop-helix protein related to the immunoglobulin E box-binding proteins.

1990 • 244 citations

Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter.

1996 • 244 citations

Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line.

1991 • 240 citations

The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes

1996 • 240 citations

The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice

1994 • 238 citations

Initiation of V(D)J recombination in vitro obeying the 12/23 rule

1996 • 232 citations

Oct-1 and CCAAT/Enhancer-binding Protein (C/EBP) Bind to Overlapping Elements within the Interleukin-8 Promoter

1997 • 231 citations

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor.

1993 • 229 citations

Regulation of lymphoid-specific immunoglobulin mu heavy chain gene enhancer by ETS-domain proteins

1993 • 228 citations

The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene.

1994 • 225 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance.

1995 • 224 citations

Defective B-1 Cell Development and Impaired Immunity against Angiostrongylus cantonensis in IL-5Rα-Deficient Mice

1996 • 223 citations

Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.

1986 • 220 citations

CD40 stimulation provides an IFN-gamma-independent and IL-4-dependent differentiation signal directly to human B cells for IgE production.

1991 • 219 citations

Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer

1990 • 218 citations

The Immunoglobulin Class Switch: Beyond “Accessibility”

1997 • 217 citations

S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.

1994 • 214 citations

PU.1 (Spi-1) autoregulates its expression in myeloid cells.

1995 • 213 citations

Functions of CD40 and Its Ligand, gp39 (CD40L)

2017 • 212 citations

Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2.

1996 • 211 citations

Regulation of V(D)J Recombination Activator Protein RAG-2 by Phosphorylation

1993 • 209 citations

Both E12 and E47 Allow Commitment to the B Cell Lineage

1997 • 209 citations

Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.

1995 • 201 citations

RAG1 Mediates Signal Sequence Recognition and Recruitment of RAG2 in V(D)J Recombination

1996 • 200 citations

A Conserved Degradation Signal Regulates RAG-2 Accumulation during Cell Division and Links V(D)J Recombination to the Cell Cycle

1996 • 199 citations

Transcriptional repression by the proto-oncogene BCL-6.

1996 • 196 citations

Positive and negative selection events during B lymphopoiesis

1995 • 195 citations

Failure of Lymphopoiesis after Adoptive Transfer of NF-κB–Deficient Fetal Liver Cells

1997 • 193 citations

The role of NF-kappa B and NF-IL6 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and interleukin-6.

1993 • 192 citations

Induction of the transcription factors NF-кB, AP-1 and NF-AT during B cell stimulation through the CD40 receptor

1995 • 192 citations

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

1993 • 190 citations

B-Cell-Specific DNA Binding by an E47 Homodimer

1995 • 187 citations

CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells.

1991 • 184 citations

STF-IL-4: a novel IL-4-induced signal transducing factor.

1994 • 183 citations

Activation of class II MHC genes requires both the X ☐ region and the class II transactivator (CIITA)

1995 • 180 citations

Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl‐2 induction

1993 • 180 citations

bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice.

1996 • 178 citations

Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases.

1996 • 175 citations

TFEB has DNA-binding and oligomerization properties of a unique helix-loop-helix/leucine-zipper family.

1991 • 174 citations

Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development

1996 • 174 citations

Displacement of an E-Box-Binding Repressor by Basic HelixLoop-Helix Proteins: Implications for B-Cell Specificity of the Immunoglobulin Heavy-Chain Enhancer

1994 • 173 citations

Differentiation of early plasma cells on bone marrow stromal cells requires interleukin-6 for escaping from apoptosis

1995 • 173 citations

Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes.

1996 • 173 citations

Deletion of the Igκ Light Chain Intronic Enhancer/Matrix Attachment Region Impairs but Does Not Abolish VκJκ Rearrangement

1996 • 172 citations

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.

1993 • 168 citations

The germinal center: a crucible for lymphocyte selection

1996 • 166 citations

Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line.

1995 • 162 citations

Regulation of Human B-Cell Activation and Adhesion

1991 • 161 citations

Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers.

1992 • 160 citations

Induction of Cell Cycle Arrest and B Cell Terminal Differentiation by CDK Inhibitor p18 and IL-6

1997 • 159 citations

Patterns of Somatic Mutations in Immunoglobulin Variable Genes

1987 • 158 citations

Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor

1996 • 158 citations

Requirement for nuclear factor (NF)-kappa B p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colony-stimulating factor promoter

1994 • 157 citations

Developmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA.

1994 • 155 citations

B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes.

1995 • 149 citations

Normal Human IgD+IgM− Germinal Center B Cells Can Express Up to 80 Mutations in the Variable Region of Their IgD Transcripts

1996 • 149 citations

Induction of B cell costimulatory function by recombinant murine CD40 ligand

1994 • 148 citations

A novel lineage-specific nuclear factor regulates mb-1 gene transcription at the early stages of B cell differentiation.

1991 • 146 citations

Signal Transducer and Activator of Transcription-3 (STAT3) Is Constitutively Activated in Normal, Self-renewing B-1 Cells but Only Inducibly Expressed in Conventional B Lymphocytes

1997 • 146 citations

Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements.

1994 • 144 citations

Transcriptional Regulation of T Cell Receptor Genes

1993 • 142 citations

Inhibition of c-myc Expression Induces Apoptosis of WEHI 231 Murine B Cells

1996 • 139 citations

Helix-loo-helix proteins in the regulation of immunoglobulin gene transcription

1992 • 139 citations

In Situ Studies of the Germinal Center Reaction

1995 • 139 citations

B lymphocytes are impaired in mice lacking the transcriptional co‐activator Bob1/OCA‐B/OBF1

1996 • 139 citations

EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains.

1995 • 138 citations

The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation.

1996 • 138 citations

IL-4 plus CD40 monoclonal antibody induces human B cells gamma subclass-specific isotype switch: switching to gamma 1, gamma 3, and gamma 4, but not gamma 2.

1995 • 137 citations

Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation.

1994 • 137 citations

CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction.

1997 • 136 citations

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen.

1995 • 134 citations

Octamer-binding proteins from B or HeLa cells stimulate transcription of the immunoglobulin heavy-chain promoter in vitro.

1988 • 132 citations

Ig/EBP (C/EBPγ) is a transdominant negative inhibitor of C/EBP family transcriptional activators

1995 • 132 citations

Differentiation of early plasma cells on bone marrow stromal cells requires interleukin-6 for escaping from apoptosis

1995 • 131 citations

The Ability of C/EBPβ but Not C/EBPα To Synergize with an Sp1 Protein Is Specified by the Leucine Zipper and Activation Domain

1997 • 130 citations

Transcription induces the formation of a stable RNA.DNA hybrid in the immunoglobulin alpha switch region.

1994 • 130 citations

The leucine zipper of TFE3 dictates helix-loop-helix dimerization specificity.

1991 • 129 citations

A Dominant Negative form of Transcription Activator mTFE3 Created by Differential Splicing

1991 • 129 citations

Ets-related protein PU.1 regulates expression of the immunoglobulin J-chain gene through a novel Ets-binding element.

1993 • 129 citations

A transcriptional repressor of c-myc

1989 • 129 citations

Signaling via IL-2 and IL-4 in JAK3-Deficient Severe Combined Immunodeficiency Lymphocytes: JAK3-Dependent and Independent Pathways

1996 • 129 citations

B-1 Cells: unique origins and functions

1996 • 129 citations

The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32

1997 • 129 citations

Regulation of germinal center B cell differentiation. Role of the human APO-1/Fas (CD95) molecule.

1995 • 127 citations

Functions of CD40 and Its Ligand, gp39 (CD40L)

1996 • 126 citations

Stat1 alpha expression is involved in IFN-gamma induction of the class II transactivator and class II MHC genes.

1996 • 125 citations

Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiation.

1994 • 125 citations

Recombinant CD40 ligand stimulation of murine B cell growth and differentiation: cooperative effects of cytokines

1993 • 125 citations

An Interleukin-2 Signal Relieves BSAP (Pax5)-Mediated Repression of the Immunoglobulin J Chain Gene

1996 • 125 citations

Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4

1994 • 125 citations

Roles of IGH and L Chains and of Surrogate H and L Chains in the Development of Cells of the B Lymphocyte Lineage

1994 • 124 citations

Multiple DNA sequence elements are necessary for the function of an immunoglobulin heavy chain promoter.

1987 • 123 citations

TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation.

1993 • 123 citations

Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases.

1995 • 122 citations

ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development.

1994 • 121 citations

T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death.

1994 • 117 citations

Combinatorial regulation of transcription II: the immunoglobulin μ heavy chain gene

1995 • 116 citations

Spi-1/PU.1: an oncogene of the Ets family

1994 • 115 citations

The Ets protein Spi-B is expressed exclusively in B cells and T cells during development.

1996 • 114 citations

Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3).

1995 • 111 citations

Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development

1996 • 108 citations

IL-7 Receptor and VDJ Recombination: Trophic Versus Mechanistic Actions

1997 • 108 citations

Cellular and molecular factors that regulate the differentiation and apoptosis of germinal center B cells. Anti-Ig down-regulates Fas expression of CD40 ligand-stimulated germinal center B cells and inhibits Fas-mediated apoptosis.

1996 • 108 citations

Germinal center B cells rescued from apoptosis by CD40 ligation or attachment to follicular dendritic cells, but not by engagement of surface immunoglobulin or adhesion receptors, become resistant to CD95‐induced apoptosis

1997 • 108 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 107 citations

The two novel MHC class II transactivators RFX5 and CIITA both control expression of HLA-DM genes

1995 • 106 citations

The Ets family of proteins: weak modulators of gene expression in quest for transcriptional partners.

1994 • 104 citations

IL4 and IL13 receptors share the γc chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells

1996 • 104 citations

Displacement of an E-box-binding repressor by basic helix-loop-helix proteins: implications for B-cell specificity of the immunoglobulin heavy-chain enhancer.

1994 • 104 citations

Modulation of the IgH enhancer's cell type specificity through a genetic switch.

1991 • 104 citations

Phosphorylation of E47 as a Potential Determinant of B-Cell-Specific Activity

1996 • 103 citations

An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures

1994 • 102 citations

CD40 signaling-mediated induction of Bcl-XL, Cdk4, and Cdk6. Implication of their cooperation in selective B cell growth.

1995 • 101 citations

Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation

1994 • 101 citations

The molecular basis of somatic hypermutation of immunoglobulin genes

1996 • 100 citations

Tissue-specific gene activation by MyoD: determination of specificity by cis-acting repression elements.

1994 • 100 citations

Complex pattern of immunoglobulin mu gene expression in normal and transgenic mice: nonoverlapping regulatory sequences govern distinct tissue specificities.

1991 • 99 citations

Pax5 (BSAP) regulates the murine immunoglobulin 3' alpha enhancer by suppressing binding of NF-alpha P, a protein that controls heavy chain transcription.

1995 • 97 citations

Reflections on STAT3, STAT5, and STAT6 as fat STATs.

1996 • 96 citations

De novo development and self-replenishment of B cells

1995 • 96 citations

CD40 ligation results in protein kinase C-independent activation of ERK and JNK in resting murine splenic B cells.

1996 • 94 citations

Gene rearrangement and B-cell development

1993 • 92 citations

IgA class switch in I alpha exon-deficient mice. Role of germline transcription in class switch recombination.

1996 • 90 citations

Activation of human B cells. Comparison of the signal transduced by IL-4 to four different competence signals.

1989 • 90 citations

Sequence-specific DNA binding of the B-cell-specific coactivator OCA-B.

1996 • 89 citations

The role of BSAP (Pax-5) in B-cell development

1995 • 87 citations

Characterization of NERF, a Novel Transcription Factor Related to the Ets Factor ELF-1

1996 • 86 citations

Activation of NF-κB/Rel by CD40 Engagement Induces the Mouse Germ Line Immunoglobulin Cγ1 Promoter

1996 • 85 citations

NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1.

1994 • 82 citations

Isolation of a B-cell-specific promoter for the human class II transactivator

1997 • 81 citations

Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates

1996 • 79 citations

Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer

1993 • 77 citations

Regulation of JAK3 expression and activation in human B cells and B cell malignancies.

1995 • 76 citations

Identification of CD36 as the first gene dependent on the B-cell differentiation factor Oct-2.

1995 • 75 citations

Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences.

1995 • 73 citations

CD40 ligand triggers interleukin-6 mediated B cell differentiation

1996 • 72 citations

Corepression of RelA and c-Rel Inhibits Immunoglobulin κ Gene Transcription and Rearrangement in Precursor B Lymphocytes

1996 • 70 citations

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.

1994 • 69 citations

Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes

1994 • 69 citations

IgM receptor-mediated transactivation of the IgH 3′ enhancer couples a novel Elf-1-AP-1 protein complex to the developmental control of enhancer function.

1995 • 69 citations

Negative selection of human germinal center B cells by prolonged BCR cross-linking.

1996 • 68 citations

Cell specific expression of human Bruton's agammaglobulinemia tyrosine kinase gene (Btk) is regulated by Sp1- and Spi-1/PU.1-family members.

1996 • 68 citations

TheJanusprotein tyrosine kinases in hematopoietic cytokine signaling

1995 • 66 citations

mTFE3, an X-Linked Transcriptional Activator Containing Basic Helix-Loop-Helix and Zipper Domains, Utilizes the Zipper To Stabilize Both DNA Binding and Multimerization

1992 • 65 citations

Octamer Binding Factors and Their Coactivator Can Activate the Murine PU.1 (spi-1) Promoter

1996 • 64 citations

CD40 function in nonhematopoietic cells. Nuclear factor kappa B mobilization and induction of IL-6 production.

1995 • 62 citations

Function of NF-κB/Rel Binding Sites in the Major Histocompatibility Complex Class II Invariant Chain Promoter Is Dependent on Cell-Specific Binding of Different NF-κB/Rel Subunits

1994 • 62 citations

Functional roles of the transcription factor Oct-2A and the high mobility group protein I/Y in HLA-DRA gene expression.

1995 • 62 citations

Cell type- and stage-specific expression of the CD20/B1 antigen correlates with the activity of a diverged octamer DNA motif present in its promoter.

1993 • 61 citations

ETS-Core Binding Factor: a Common Composite Motif in Antigen Receptor Gene Enhancers

1998 • 61 citations

Involvement of the Ets Family Factor PU.1 in the Activation of Immunoglobulin Promoters

1995 • 61 citations

Multiple motifs regulate the B-cell-specific promoter of the B29 gene.

1993 • 61 citations

The 3′ enhancer region determines the B/T specificity and pro-B/pre-B specificity of immunoglobulin Vκ-Jκ joining

1995 • 59 citations

A Potential Role for Elf-1 in Terminal Transferase Gene Regulation

1996 • 59 citations

Human follicular dendritic cells enhance cytokine-dependent growth and differentiation of CD40-activated B cells.

1995 • 58 citations

Regulation of Expression of the Interleukin 6 Gene: Structure and Function of the Transcription Factor NF‐IL6

2007 • 57 citations

The CD5/CD72 receptor system is coexpressed with several functionally relevant counterstructures on human B cells and delivers a critical signaling activity.

1996 • 56 citations

Interleukin 4 activates a signal transducer and activator of transcription (Stat) protein which interacts with an interferon-gamma activation site-like sequence upstream of the I epsilon exon in a human B cell line. Evidence for the involvement of Janus kinase 3 and interleukin-4 Stat.

1995 • 55 citations

The physiology of germinal centers.

1996 • 53 citations

An immunoglobulin promoter region is unaltered by DNA rearrangement and somatic mutation during B-cell development

1982 • 53 citations

A Three-protein-DNA Complex on a B Cell-specific Domain of the Immunoglobulin μ Heavy Chain Gene Enhancer

1997 • 51 citations

Transcriptional Controlling Elements in the Immunoglobulin and T Cell Receptor Loci

1988 • 51 citations

Selective Utilization of Basic Helix-Loop-Helix–Leucine Zipper Proteins at the Immunoglobulin Heavy-Chain Enhancer

1997 • 50 citations

Cell cycle regulation of immunoglobulin class switch recombination and germ‐line transcription: potential role of Ets family members

1995 • 50 citations

Regulation of Immunoglobulin Gene Transcription

1992 • 50 citations

Antigen-receptor engagement in B cells induces nuclear expression of STAT5 and STAT6 proteins that bind and transactivate an IFN-gamma activation site.

1996 • 48 citations

Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1 [published erratum appears in Nucleic Acids Res 1996 Jun 15;24(12):2462]

1996 • 47 citations

Lymphoid- and myeloid-specific activity of the PU.1 promoter is determined by the combinatorial action of octamer and ets transcription factors.

1995 • 46 citations

Limited expression of C/EBP family proteins during B lymphocyte development. Negative regulator Ig/EBP predominates early and activator NF-IL-6 is induced later.

1994 • 46 citations

Regulation of the RAG-1 promoter by the NF-Y transcription factor.

1997 • 46 citations

The basic helix-loop-helix-zipper domain of TFE3 mediates enhancer-promoter interaction.

1994 • 45 citations

TFE3 contains two activation domains, one acidic and the other proline-rich, that synergistically activate transcription

1995 • 44 citations

BCL-6 EXPRESSION IN REACTIVE LYMPHOID TISSUE AND IN B-CELL NON-HODGKIN'S LYMPHOMAS

1996 • 44 citations

Binding and cooperative interactions between two B cell-specific transcriptional coactivators.

1996 • 43 citations

Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site.

1994 • 40 citations

Transcriptional control points during lymphopoiesis

1994 • 40 citations

Antigen receptor‐induced apoptosis of human germinal center B cells is targeted to a centrocytic subset

1997 • 40 citations

Specificity in V(D)J recombination: new lessons from biochemistry and genetics

1997 • 40 citations

Engagement of CD20 suppresses apoptosis in germinal center B cells

1995 • 39 citations

A T cell controlled molecular pathway regulating the IgH locus: CD40-mediated activation of the IgH 3′ enhancer.

1996 • 39 citations

Structure of the T15 VH gene subfamily: identification of immunoglobulin gene promotor homologies.

1987 • 39 citations

Precise Alignment of Sites Required for μ Enhancer Activation in B Cells

1996 • 39 citations

Maintenance of Human Germinal Center B Cells In Vitro

1997 • 39 citations

γ Chain-associated Cytokine Receptors Signal through Distinct Transducing Factors

1995 • 38 citations

Lack of type 2 T cell-independent B cell responses and defect in isotype switching in TNF-lymphotoxin alpha-deficient mice.

1997 • 37 citations

Function of NF-kappa B/Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa B/Rel subunits.

1994 • 37 citations

Isolation and characterization of a TATA-less promoter for the human RAG-1 gene

1996 • 36 citations

The Absence of the Transcription Activator TFE3 Impairs Activation of B Cells In Vivo

1997 • 34 citations

The hematopoietic transcription factor PU.1 is downregulated in human multiple myeloma cell lines

1995 • 34 citations

Genetic Analysis of Tyrosine Kinase Function in B Cell Development

1996 • 34 citations

Regulation of the Pro-B-Cell-Specific Enhancer of the Id1 Gene Involves the C/EBP Family of Proteins

1997 • 33 citations

The κB Enhancer of the Human Interleukin-6 Promoter Is Necessary and Sufficient to Confer an IL-1β and TNF-α Response in Transfected Human Cell Lines: Requirement for Members of the C/EBP Family for Activity

1996 • 33 citations

Active suppression of the class II transactivator‐encoding AIR‐1 locus is responsible for the lack of major histocompatibility complex class II gene expression observed during differentiation from B cells to plasma cells

1996 • 31 citations

Context dependent transactivation domains activate the immunoglobulin mu heavy chain gene enhancer.

1996 • 31 citations

Developmental and Molecular Regulation of Immunoglobulin Class Switch Recombination

1996 • 30 citations

The JAK/STAT pathway.

1996 • 28 citations

Regulation of Antibody Class Switching to IgE: Characterization of an IL‐4‐Responsive Region in the Immunoglobulin Heavy‐Chain Germline ε Promoter^a

1995 • 27 citations

mTFE3, an X-linked transcriptional activator containing basic helix-loop-helix and zipper domains, utilizes the zipper to stabilize both DNA binding and multimerization.

1992 • 26 citations

Characterization of thecis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches

1996 • 26 citations

The propensity to apoptosis of centrocytes and centroblasts correlates with elevated levels of intracellular myc protein

1997 • 25 citations

Regulation of gene expression at early stages of B-cell and T-cell differentation

1996 • 24 citations

The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression.

1996 • 23 citations

Structure, chromosomal localization, and methylation pattern of the human mb-1 gene.

1994 • 23 citations

Characterization of the expression and gene promoter of CD22 in murine B cells

1996 • 21 citations

Delayed tyrosine phosphorylation and nuclear expression of STAT1 following antigen receptor stimulation of B lymphocytes.

1996 • 19 citations

Simultaneous activation of Ig and Oct-2 synthesis and reduction of surface MHC class II expression by IL-6.

1994 • 19 citations

Ets-1 activates the DRA promoter in B cells.

1994 • 17 citations

Lessons in Transcriptional Regulation Learned from Studies on Immunoglobulin Genes

1995 • 15 citations

Functional Analysis of IL‐6 and IL‐6DBP/C/EBPβ by Gene Targeting

1995 • 14 citations

Targeting and Regulation of Immunoglobulin Gene Somatic Hypermutation and lsotype Switch Recombination

1995 • 14 citations

Regulation of immunoglobulin gene transcription

1995 • 13 citations

An Alternatively Spliced Isoform of the Spi-B Transcription Factor

1996 • 11 citations

Cloning and Characterization of the Murine B-Cell Specific Transcriptional Coactivator Bob1

1996 • 8 citations

BCL‐6 EXPRESSION IN REACTIVE LYMPHOID TISSUE AND IN B‐CELL NON‐HODGKIN'S LYMPHOMAS

1996 • 5 citations

Plasma cell tumors decrease CD23 mRNA expression in vivo in murine splenic B cells

1995 • 4 citations

Rearrangement of the bcl‐6 gene in Hodgkin's disease, lymphocyte predominant type

1996 • 1 citations