Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

T Cell-Independent Antigens Type 2

1995 • 798 citations

Defective B cell development and function in Btk-deficient mice

1995 • 729 citations

Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice

1995 • 663 citations

Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes

1993 • 631 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM).

1995 • 463 citations

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.

1994 • 426 citations

Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells.

1993 • 413 citations

Molecular components of the B-cell antigen receptor complex of the IgM class

1990 • 401 citations

Targeted disruption of µ chain membrane exon causes loss of heavy-chain allelic exclusion

1992 • 376 citations

Expansion and functional activity of Ly‐1⁺ B cells upon transfer of peritoneal cells into allotype‐congenic, newborn mice

1987 • 318 citations

Impaired expansion of mouse B cell progenitors lacking Btk

1995 • 314 citations

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

1993 • 311 citations

The B Cell Antigen Receptor Complex: Association of Ig-α and Ig-β with Distinct Cytoplasmic Effectors

1992 • 307 citations

Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin‐10 in interferon‐γ and in interleukin‐4‐expressing cells

1994 • 305 citations

The B-cell antigen receptor of the five immunoglobulin classes

1991 • 302 citations

IL-2 receptor α chain (CD25JAC) expression defines a crucial stage in pre-B cell development

1994 • 284 citations

Syk Protein-tyrosine Kinase Is Regulated by Tyrosine-phosphorylated Iga/Ig/3 Immunoreceptor Tyrosine Activation Motif Binding and Autophosphorylation

1995 • 270 citations

CD5 B Cells, a Fetal B Cell Lineage

1993 • 252 citations

Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement.

1994 • 250 citations

Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta.

1993 • 237 citations

Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells.

1993 • 218 citations

Establishment of a germ-line competent C57BL/6 embryonic stem cell line

1991 • 204 citations

Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells.

1994 • 196 citations

Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor.

1994 • 190 citations

Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation.

1994 • 189 citations

Pre-B cells in mouse bone marrow: immunofluorescence stathmokinetic studies of the proliferation of cytoplasmic mu-chain-bearing cells in normal mice.

1983 • 188 citations

B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia.

1994 • 187 citations

Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development

1996 • 174 citations

Idiotypic analysis of the response of C57BL/6 mice to the (4‐hydroxy‐3‐nitrophenyl)acetyl group

1977 • 171 citations

Early B‐Cell Development in the Mouse: Insights from Mutations Introduced by Gene Targeting

1994 • 142 citations

Differential signaling through the Ig‐α and Ig‐β components of the B cell antigen receptor

1993 • 137 citations

The Role of Igβ in Precursor B Cell Transition and Allelic Exclusion

1995 • 133 citations

Identification of the genes encoding the IgM‐α and Ig‐β components of the IgM antigen receptor complex by amino‐terminal sequencing

1990 • 131 citations

X-Linked Immune Deficiency (xid) of CBA/N Mice

1986 • 123 citations

Role of B cell receptor Igα and Igβ subunits in MHC class II-restricted antigen presentation

1995 • 115 citations

B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn

1993 • 112 citations

The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases.

1992 • 103 citations

Antigen presentation by the B cell antigen receptor is driven by the αβ sheath and occurs independently of its cytoplasmic tyrosines

1993 • 101 citations

X‐Linked Agammaglobulinemia: New Approaches to Old Questions based on the Identification of the Defective Gene

1994 • 86 citations

The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line.

1992 • 82 citations

Signaling-defective mutants of the B lymphocyte antigen receptor fail to associate with Ig-alpha and Ig-beta/gamma.

1993 • 76 citations

Structure of the murine mb-1 gene encoding a putative sIgM-associated molecule.

1990 • 64 citations

Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45.

1994 • 58 citations

The structure of the μ/pseudo light chain complex on human pre‐B cells is consistent with a function in signal transduction

1993 • 56 citations

More efficient positive selection of thymocytes in mice lacking terminal deoxynucleotidyl transferase

1994 • 54 citations

Early and late B-cell development in the mouse

1992 • 53 citations

Females with a disorder phenotypically identical to X-linked agammaglobulinemia

1992 • 49 citations

Role of the mu immunoglobulin heavy chain transmembrane and cytoplasmic domains in B cell antigen receptor expression and signal transduction.

1993 • 48 citations

Cross-linking of B cell receptor-related MB-1 molecule induces protein tyrosine phosphorylation in early B lineage cells.

1993 • 40 citations

Specificity and heterogeneity of helper T cells in the response to serum albumins in mice

1974 • 29 citations

The protein defective in X‐linked agammaglobulinemia, Bruton's tyrosine kinase, shows increased autophosphorylation activity in vitro when isolated from cells in which the B cell receptor has been cross‐linked

1995 • 19 citations