S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Fluorescence Microscopy: Reduced Photobleaching of Rhodamine and Fluorescein Protein Conjugates by n -Propyl Gallate

1982 • 851 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

Handbook of experimental immunology

1987 • 680 citations

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.

1989 • 567 citations

Mechanism and Regulation of Immunoglobulin Isotype Switching

1993 • 516 citations

T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.

1982 • 445 citations

Production of homozygous mutant ES cells with a single targeting construct.

1992 • 418 citations

IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice

1990 • 410 citations

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

1993 • 393 citations

Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice.

1991 • 376 citations

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

1986 • 344 citations

Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element

1993 • 340 citations

IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide.

1988 • 308 citations

VDJ recombination

1992 • 307 citations

Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.

1988 • 285 citations

Mitogen- and IL-4-regulated expression of germ-line Ig γ2b transcripts: Evidence for directed heavy chain class switching

1988 • 277 citations

The role of DNA topoisomerases in recombination and genome stability: A double-edged sword?

1990 • 236 citations

Cμ-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5′-nontranslatable exon

1985 • 232 citations

Immunoglobulin Class Switching: Molecular and Cellular Analysis

1990 • 224 citations

Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.

1986 • 220 citations

Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.

1980 • 213 citations

Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells.

1988 • 208 citations

A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.

1993 • 206 citations

Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma.

1989 • 172 citations

The role of gene deletion in the immunoglobulin heavy chain switch

1980 • 164 citations

Production of Homozygous Mutant ES Cells with a Single Targeting Construct

1992 • 140 citations

Molecular characterization of germ-line immunoglobulin A transcripts produced during transforming growth factor type beta-induced isotype switching.

1990 • 138 citations

Structure and expression of germ line immunoglobulin gamma 2b transcripts.

1988 • 136 citations

Rapid induction of transcription of unrearranged S gamma 1 switch regions in activated murine B cells by interleukin 4.

1989 • 134 citations

Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts.

1991 • 115 citations

Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.

1993 • 114 citations

Structure and expression of germ line immunoglobulin heavy-chain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon.

1990 • 111 citations

Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression

1980 • 106 citations

The murine IgG₁/IgE class switch program

1992 • 105 citations

IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression.

1989 • 97 citations

Humoral immune functions in IL-4 transgenic mice.

1991 • 86 citations

Quantitation of immunoglobulin mu-gamma 1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method.

1992 • 80 citations

Structure and expression of germline immunoglobulin γ³ heavy chain gene transcripts: implications for mitogen and lymphokine directed class-switching

1990 • 76 citations

Structure and expression of murine germ-line immunoglobulin epsilon heavy chain transcripts induced by interleukin 4.

1990 • 72 citations

B cell differentiation induced by lipopolysaccharide. IV. Development of immunoglobulin class restriction in precursors of IgG-synthesizing cells.

1976 • 63 citations

Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre-B cells.

1987 • 59 citations

Studies on Murine IgE with Monoclonal Antibodies

1988 • 57 citations

Transcription-driven site-specific DNA recombination in vitro.

1993 • 49 citations

An antisense oligonucleotide complementary to a sequence in I gamma 2b increases gamma 2b germline transcripts, stimulates B cell DNA synthesis, and inhibits immunoglobulin secretion.

1992 • 43 citations

Effect of downregulation of germline transcripts on immunoglobulin A isotype differentiation.

1993 • 39 citations

Identification of a Conserved Lipopolysaccharide-Plus-Interleukin-4-Responsive Element Located at the Promoter of Germ Line ε Transcripts

1991 • 39 citations

Structure and Expression of Germ Line Immunoglobulin γ2b Transcripts

1988 • 36 citations

Structure and Expression of Germ Line Immunoglobulin Heavy-Chain ε Transcripts: Interleukin-4 Plus Lipopolysaccharide-Directed Switching to Cε

1990 • 33 citations

The molecular events in heavy chain class-switching.

1989 • 21 citations

A retroviral expression vector containing murine immunoglobullin heavy chain promoter/enhancer

1988 • 19 citations